Benzodiazepines Block α₂-Containing Inhibitory Glycine Receptors in Embryonic Mouse Hippocampal Neurons

[6] Correction for liquid junction potentials in patch clamp experiments

1992 • 1,148 citations

Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors

1998 • 880 citations

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

1995 • 614 citations

Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain.

1991 • 548 citations

The glycinergic inhibitory synapse

2001 • 519 citations

The anti‐epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA‐ and glycine‐gated currents

2002 • 329 citations

Nonsynaptic Glycine Receptor Activation during Early Neocortical Development

1998 • 316 citations

The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.

1992 • 305 citations

The glycine receptor

1997 • 289 citations

Benzodiazepines specifically modulate GABA-mediated postsynaptic inhibition in cultured mammalian neurones

1978 • 276 citations

Cotransmission of GABA and Glycine to Brain Stem Motoneurons

1999 • 252 citations

Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms

2000 • 242 citations

Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor

1990 • 237 citations

Potassium-Coupled Chloride Cotransport Controls Intracellular Chloride in Rat Neocortical Pyramidal Neurons

2000 • 220 citations

β‐Alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro

2002 • 200 citations

A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit

1990 • 183 citations

Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.

1995 • 180 citations

Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: identification of amino acid residues involved in taurine activation.

1992 • 177 citations

Pharmacological Characterization of Glycine-Gated Chloride Currents Recorded in Rat Hippocampal Slices

2002 • 155 citations

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.

1994 • 145 citations

Alternative splicing generates two isoforms of the α2 subunit of the inhibitory glycine receptor

1991 • 143 citations

Strychnine‐sensitive glycine responses of neonatal rat hippocampal neurones.

1991 • 141 citations

Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant.

1994 • 136 citations

Interaction of Benzodiazepines with Central Nervous Glycine Receptors: Possible Mechanism of Action

1974 • 136 citations

Chlordiazepoxide selectively potentiates GABA conductance of spinal cord and sensory neurons in cell culture.

1981 • 128 citations

Taurine activates GABAA but not GABAB receptors in rat hippocampal CA1 area

2000 • 128 citations

Mutations Affecting the Glycine Receptor Agonist Transduction Mechanism Convert the Competitive Antagonist, Picrotoxin, into an Allosteric Potentiator

1995 • 122 citations

γ‐Aminobutyric acid_A receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development

2001 • 121 citations

Differential blockade of bicuculline and strychnine on GABA- and glycine-induced responses in dissociated rat hippocampal pyramidal cells

1991 • 108 citations

Abnormal visual cortex development in the kitten associated with maternal dietary taurine deprivation

1986 • 102 citations

Glycine-gated chloride current in acutely isolated rat hypothalamic neurons

1989 • 99 citations

Treatment of electrical status epilepticus by short diazepam (DZP) cycles after DZP rectal bolus test

1995 • 95 citations

Subunit-specific modulation of glycine receptors by neurosteroids

2001 • 85 citations

Properties of glycine-activated conductances in rat brain neurones

1988 • 81 citations

Glycine receptors containing the α4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge

2000 • 80 citations

A Reluctant Gating Mode of Glycine Receptor Channels Determines the Time Course of Inhibitory Miniature Synaptic Events in Zebrafish Hindbrain Neurons

1998 • 80 citations

Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area.

2001 • 76 citations

Activation of human α1 and α2 homomeric glycine receptors by taurine and GABA

2001 • 75 citations

Characterization of strychnine-sensitive glycine receptors in acutely isolated adult rat basolateral amygdala neurons

2000 • 65 citations

Activation and block of recombinant GABA_A receptors by pentobarbitone: a single‐channel study

2000 • 60 citations

Desensitization of Homomeric α1 Glycine Receptor Increases with Receptor Density

2002 • 53 citations

A Novel Domain of the Inhibitory Glycine Receptor Determining Antagonist Efficacies: Further Evidence for Partial Agonism Resulting from Self-Inhibition

1999 • 51 citations

Subunit composition of strychnine‐sensitive glycine receptors expressed by adult rat basolateral amygdala neurons

2001 • 49 citations

Expression of inhibitory glycine receptors in postnatal rat cerebral cortex

1993 • 48 citations

Developmental study of benzodiazepine effects on monosynaptic GABAA-mediated IPSPs of rat hippocampal neurons

1993 • 48 citations

Modulation of neurotransmitter receptor desensitization: chlordiazepoxide stimulates fading of the GABA response

1988 • 47 citations

Binding site stoichiometry and the effects of phosphorylation on human α1 homomeric glycine receptors

2002 • 46 citations

Action of diazepam on the voltage-dependent Na+ current. Comparison with the effects of phenytoin, carbamazepine, lidocaine and flumazenil

1991 • 43 citations

Does β-alanine activate more than one chloride channel associated receptor?

1988 • 42 citations

Multiple picrotoxinin effect on glycine channels in rat hippocampal neurons

1998 • 41 citations

Glycine Receptor β Subunits Play a Critical Role in Potentiation of Glycine Responses by ICS-205,930

2000 • 40 citations

A characterization of glycinergic receptors present in cultured rat medullary neurons

1991 • 37 citations

Kinetic Analysis of Glycine Receptor Currents in Ventral Cochlear Nucleus

1998 • 37 citations

Potentiation of gamma-aminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons.

1993 • 36 citations

Nonketotic Hyperglycinemia: Treatment with Diazepam—A Competitor for Glycine Receptors

1983 • 35 citations

Inhibitory effect of ondansetron on glycine response of dissociated rat hippocampal neurons.

1999 • 32 citations

Subunit-Specific Action of an Anticonvulsant Thiobutyrolactone on Recombinant Glycine Receptors Involves a Residue in the M2 Membrane-Spanning Region

2000 • 30 citations

Expression and mRNA splicing of glycine receptor subunits and gephyrin during neuronal differentiation of P19 cells in vitro, studied by RT-PCR and immunocytochemistry

1997 • 28 citations

Mice with Glycine Receptor Subunit Mutations Are Both Sensitive and Resistant to Volatile Anesthetics

2002 • 28 citations

Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the β‐amino acid agonist, taurine

2001 • 25 citations

Ethanol Inhibition of Glycine-Activated Responses in Neurons of Ventral Tegmental Area of Neonatal Rats

2001 • 23 citations

Modulation of glycine responses by dihydropyridines and verapamil in rat spinal neurons

2001 • 21 citations

Benzodiazepine activity: is interaction with the glycine receptor, as evidenced by displacement of strychnine binding, a useful criterion?

1977 • 20 citations

Glycine conductance changes in chick spinal cord neurons developing in culture

1993 • 15 citations

Effects of medazepam on voltage-gated ion currents of cultured chick sensory neurons

1987 • 13 citations

Heterogeneous current responses to GABA and glycine are present in post-natally cultured hippocampal neurons

1995 • 9 citations