Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Molecular and cellular mechanisms of general anaesthesia

1994 • 1,779 citations

P-type calcium channels in rat central and peripheral neurons

1992 • 788 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

Anesthetic Potency (MAC) Is Independent of Forebrain Structures in the Rat

1993 • 555 citations

Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain.

1991 • 548 citations

Exaggerated Anesthetic Requirements in the Preferentially Anesthetized Brain

1993 • 536 citations

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1995 • 535 citations

A pharmacological study of the depression of spinal neurones by glycine and related amino acids

1968 • 505 citations

Anesthetic Potency Is Not Altered after Hypothermic Spinal Cord Transection in Rats

1994 • 410 citations

Strychnine Binding Associated with Glycine Receptors of the Central Nervous System

1973 • 388 citations

Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

1988 • 388 citations

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

1991 • 350 citations

The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.

1992 • 305 citations

Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways

1993 • 286 citations

Stereospecific Effects of Inhalational General Anesthetic Optical Isomers on Nerve Ion Channels

1991 • 284 citations

Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes.

1990 • 272 citations

Neurotransmitter action: Opening of ligand-gated ion channels

1993 • 267 citations

Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers.

1993 • 239 citations

Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor

1990 • 237 citations

THE ACTION OF FLUOTHANE*—A NEW VOLATILE ANAESTHETIC

1956 • 219 citations

SELECTIVE ACTIONS OF VOLATILE GENERAL ANAESTHETICS AT MOLECULAR AND CELLULAR LEVELS

1993 • 216 citations

The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex

1995 • 205 citations

Temperature Dependence of the Potency of Volatile General Anesthetics

1996 • 198 citations

Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor.

1989 • 192 citations

Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor.

1990 • 189 citations

Assembly of the inhibitory glycine receptor: Identification of amino acid sequence motifs governing subunit stoichiometry

1993 • 183 citations

Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: identification of amino acid residues involved in taurine activation.

1992 • 177 citations

Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons

1993 • 177 citations

Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane.

1993 • 164 citations

Structure and function of inhibitory glycine receptors

1992 • 162 citations

Functional chloride channels by mammalian cell expression of rat glycine receptor subunit

1989 • 159 citations

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.

1994 • 145 citations

Strychnine‐sensitive glycine responses of neonatal rat hippocampal neurones.

1991 • 141 citations

Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat

1991 • 134 citations

Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes.

1994 • 119 citations

The stereospecific effects of isoflurane isomers in vivo

1994 • 113 citations

Stereoselective and non‐stereoselective actions of isoflurane on the GABA_A receptor

1994 • 111 citations

Glycine-gated chloride current in acutely isolated rat hypothalamic neurons

1989 • 99 citations

Actions of general anaesthetics on 5‐HT₃ receptors in N1E‐115 neuroblastoma cells

1996 • 90 citations

Properties of glycine-activated conductances in rat brain neurones

1988 • 81 citations

Isoflurane anesthesia is stereoselective

1992 • 80 citations

Acetylcholine Receptors: Too Many Channels, Too Few Functions

1995 • 73 citations

Expression of the human glycine receptor alpha 1 subunit in Xenopus oocytes: apparent affinities of agonists increase at high receptor density.

1994 • 71 citations

Properties of human brain glycine receptors expressed in Xenopus oocytes

1984 • 64 citations

Stereospecific actions of the inhalation anesthetic isoflurane at the GABAA receptor complex

1993 • 63 citations

Glycine exerts potent inhibitory actions on mammalian olfactory bulb neurons

1994 • 57 citations

Isoflurane's Enhancement of Chloride Flux through Rat Brain γ-Aminobutyric Acid Type A Receptors Is Stereoselective

1995 • 51 citations

Actions of General Anesthetics on Acetylcholine Receptor-rich Membranes from Torpedo californica

1986 • 50 citations

Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones of Lymnaea stagnalis

1995 • 48 citations

The effects of isoflurane on acetylcholine receptor channels.: 2. Currents elicited by rapid perfusion of acetylcholine.

1993 • 46 citations

The interaction of trichloroethanol with murine recombinant 5‐HT₃ receptors

1995 • 45 citations

The solubility of volatile anaesthetics in water at 25.0°C using 19F NMR spectroscopy

1992 • 38 citations

A characterization of glycinergic receptors present in cultured rat medullary neurons

1991 • 37 citations

Activation of endogenous protein kinase C enhances currents through α1 and α2 glycine receptor channels

1995 • 32 citations

Action of enflurane on cholinergic transmission in identified Aplysia neurones

1986 • 32 citations

Gas chromatographic headspace analysis of sevoflurane in blood

1992 • 25 citations

Coexpression of the receptor‐associated protein gephyrin changes the ligand binding affinities of α₂ glycine receptors

1992 • 22 citations

Electrophysiological properties of newborn and adult rat spinal cord glycine receptors expressed in Xenopus oocytes.

1994 • 19 citations

The effect of high pressure on glycine- and kainate-sensitive receptor channels expressed in Xenopus oocytes

1993 • 19 citations

Strychnine-sensitive glycine receptors in cultured primary neurons from rat neocortex

1993 • 12 citations