Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

Molecular and cellular mechanisms of general anaesthesia

1994 • 1,779 citations

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1995 • 535 citations

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

1991 • 350 citations

Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects

1985 • 236 citations

Binding of Xenon to Sperm Whale Myoglobin

1965 • 235 citations

A relationship between alcohol intoxication and the disordering of brain membranes by a series of short-chain alcohols.

1981 • 204 citations

Enhancement of homomeric glycine receptor function by longchain alcohols and anaesthetics

1996 • 201 citations

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.

1996 • 193 citations

Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons

1993 • 177 citations

Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane.

1993 • 164 citations

Correlation of general anesthetic potency with solubility in membranes

1981 • 154 citations

A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.

1996 • 153 citations

A discrete site for general anesthetics on a postsynaptic receptor.

1995 • 140 citations

General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium.

1992 • 139 citations

Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes

1996 • 128 citations

Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia.

1994 • 127 citations

Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital.

1995 • 114 citations

Actions of long chain alcohols on GABA_a and glutamate receptors: relation to in vivo effects

1996 • 111 citations

Ethanol inhibition of nicotinic acetylcholine type alpha 7 receptors involves the amino-terminal domain of the receptor.

1996 • 110 citations

Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics.

1996 • 101 citations

Anaesthetic concentrations of alcohols potentiate GABAA receptor-mediated currents: lack of subunit specificity

1994 • 86 citations

Modulation of the GABAA receptor by propofol is independent of the gamma subunit.

1995 • 76 citations

Volatile general anaesthetic actions on recombinant nACh_α7, 5‐HT₃ and chimeric nACh_α7‐5‐HT₃ receptors expressed in Xenopus oocytes

1997 • 66 citations

Halothane binds in the adenine‐specific niche of crystalline adenylate kinase

1977 • 56 citations

Binding of Cyclopropane to Sperm Whale Myoglobin

1967 • 55 citations

Restriction site-independent formation of chimeras from homologous neurotransmitter-transporter cDNAs.

1994 • 44 citations

Chimeric GABA A /Glycine Receptors: Expression and Barbiturate Pharmacology

1996 • 29 citations