Mutations in the M1 region of the nicotinic acetylcholine receptor alter the sensitivity to inhibition by quinacrine

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

A transient calcium‐dependent chloride current in the immature Xenopus oocyte.

1983 • 627 citations

Structure of Biological Membranes

1966 • 545 citations

Ligand-gated ion channels in the brain: The amino acid receptor superfamily

1990 • 397 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Expression of functional acetylcholine receptor from cloned cDNAs

1984 • 366 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

Neurotransmitter action: Opening of ligand-gated ion channels

1993 • 267 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata.

1981 • 113 citations

Explorations of the nicotinic acetylcholine receptor.

1989 • 113 citations

The reaction site of a non-competitive antagonist in the delta-subunit of the nicotinic acetylcholine receptor.

1986 • 104 citations

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

1990 • 104 citations

The noncompetitive blocker [³H]chlorpromazine labels segment M2 but not segment M 1 of the nicotinic acetylcholine receptor α‐subunit

1989 • 99 citations

Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function

1994 • 94 citations

Effects of chlorpromazine and phencyclidine on mouse C2 acetylcholine receptor kinetics.

1986 • 83 citations

The sidedness of the COOH terminus of the acetylcholine receptor δ subunit

1989 • 69 citations

The nicotinic acetylcholine receptor

1981 • 60 citations

Quinacrine (mepacrine) action at frog end‐plate.

1980 • 57 citations

Characterization of the transient agonist-triggered state of the acetylcholine receptor rapidly labeled by the noncompetitive blocker [3H]chlorpromazine: additional evidence for the open channel conformation

1986 • 56 citations

Time-resolved photolabeling by quinacrine azide of a noncompetitive inhibitor site of the nicotinic acetylcholine receptor in a transient, agonist-induced state.

1985 • 51 citations

End‐plate channel opening and the kinetics of quinacrine (mepacrine) block.

1980 • 45 citations

Functional role of the cysteine 451 thiol group in the M4 helix of the .gamma. subunit of Torpedo californica acetylcholine receptor

1990 • 43 citations

Quinacrine binds to the lipid-protein interface of the Torpedo acetylcholine receptor: a fluorescence study.

1992 • 37 citations

Transverse localization of the quinacrine binding site on the Torpedo acetylcholine receptor.

1993 • 21 citations

Quinacrine and ethidium bind to different loci on the Torpedo acetylcholine receptor

1993 • 19 citations

The interaction of atebrin with phospholipid vesicles

1975 • 17 citations