Molecular Determinants of Proton Modulation of Glycine Receptors

Transmitter timecourse in the synaptic cleft: its role in central synaptic function

1996 • 599 citations

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

1990 • 553 citations

Modulation of pH by neuronal activity

1992 • 533 citations

The glycinergic inhibitory synapse

2001 • 519 citations

Modulation of the N-methyl-D-aspartate channel by extracellular H+.

1990 • 458 citations

Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

1988 • 388 citations

Nonsynaptic Glycine Receptor Activation during Early Neocortical Development

1998 • 316 citations

The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.

1992 • 305 citations

Development of Glycinergic Synaptic Transmission to Rat Brain Stem Motoneurons

1998 • 267 citations

Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?

2002 • 223 citations

Effects of extracellular pH on voltage‐gated Na+, K+ and Ca2+ currents in isolated rat CA1 neurons.

1996 • 213 citations

Distribution of glycine-immunoreactive cell bodies and fibers in the rat brain

1996 • 195 citations

Zn2+ and H+ Are Coactivators of Acid-sensing Ion Channels

2001 • 192 citations

Molecular determinants of coordinated proton and zinc inhibition of N- methyl- <scp>d</scp> -aspartate NR1/NR2A receptors

2000 • 172 citations

Strychnine Binding in Rat Spinal Cord Membranes Associated with the Synaptic Glycine Receptor: Cooperativity of Glycine Interactions

1974 • 165 citations

Acidosis-related damage.

1996 • 164 citations

Extra‐ and Intracellular pH During Near‐Complete Forebrain Ischemia in the Rat

1986 • 149 citations

Mutation of Glycine Receptor Subunit Creates β-Alanine Receptor Responsive to GABA

1993 • 147 citations

Distinct agonist- and antagonist-binding sites on the glycine receptor

1992 • 132 citations

Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site.

1992 • 111 citations

Kinetic and mutational analysis of Zn²⁺ modulation of recombinant human inhibitory glycine receptors

2000 • 108 citations

Proton sensitivity of the GABA(A) receptor is associated with the receptor subunit composition.

1996 • 104 citations

Molecular Determinants of Proton-Sensitive N-Methyl-d-aspartate Receptor Gating

2003 • 103 citations

Identification of an inhibitory Zn²⁺ binding site on the human glycine receptor α1 subunit

1999 • 97 citations

The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.

1995 • 87 citations

A Single Histidine Residue Determines the pH Sensitivity of the Pacemaker Channel HCN2

2001 • 70 citations

Effect of Extracellular pH on GABA-Activated Current in Rat Recombinant Receptors and Thin Hypothalamic Slices

1999 • 69 citations

Synergism at central synapses due to lateral diffusion of transmitter.

1988 • 67 citations

Insights into the Structural Basis for Zinc Inhibition of the Glycine Receptor

2003 • 58 citations

Mutation of histidine 286 of the human P2X₄ purinoceptor removes extracellular pH sensitivity

2000 • 56 citations

A Novel Domain of the Inhibitory Glycine Receptor Determining Antagonist Efficacies: Further Evidence for Partial Agonism Resulting from Self-Inhibition

1999 • 51 citations

Proton block of rat brain sodium channels. Evidence for two proton binding sites and multiple occupancy.

1993 • 41 citations

Identification of a New Ligand Binding Domain in the α1 Subunit of the Inhibitory Glycine Receptor

1999 • 37 citations

The ρ1 GABA receptor cloned from rat retina is down-modulated by protons

1996 • 34 citations

Requirement of Multiple Protein Domains and Residues for GatingKATP Channels by Intracellular pH

2001 • 31 citations

Proton inhibition of GABA-activated current in rat primary sensory neurons

1998 • 30 citations

Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the β‐amino acid agonist, taurine

2001 • 25 citations

Modulation of nicotinic acetylcholine receptor channel by pH: A difference in pH sensitivity ofTorpedo and mouse receptors expressed inXenopus oocytes

1992 • 15 citations