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2000 • 35,287 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution

1985 • 3,049 citations

The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain

1951 • 2,750 citations

Crystal structure of an integral membrane light-harvesting complex from photosynthetic bacteria

1995 • 2,683 citations

Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

1996 • 2,561 citations

Knowledge‐based protein secondary structure assignment

1995 • 2,460 citations

Three-dimensional model of purple membrane obtained by electron microscopy

1975 • 2,259 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å

1996 • 2,089 citations

Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution

2001 • 2,033 citations

Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans

1995 • 1,991 citations

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution

2000 • 1,768 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Structural determinants of water permeation through aquaporin-1

2000 • 1,710 citations

MEMBRANE PROTEIN FOLDING AND STABILITY: Physical Principles

1999 • 1,707 citations

Complete Structure of the 11-Subunit Bovine Mitochondrial Cytochrome bc ₁ Complex

1998 • 1,214 citations

Structural basis of water-specific transport through the AQP1 water channel

2001 • 1,105 citations

Molecular Basis of Mechanotransduction in Living Cells

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The Ionic Channels in Excitable Membranes

1975 • 1,096 citations

PROMOTIF—A program to identify and analyze structural motifs in proteins

1996 • 1,046 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

Structure of a Glycerol-Conducting Channel and the Basis for Its Selectivity

2000 • 980 citations

Structure of the MscL Homolog from Mycobacterium tuberculosis : A Gated Mechanosensitive Ion Channel

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Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

The GxxxG motif: A framework for transmembrane helix-helix association

2000 • 905 citations

The Voltage Sensor in Voltage-Dependent Ion Channels

2000 • 854 citations

Energy of an Ion crossing a Low Dielectric Membrane: Solutions to Four Relevant Electrostatic Problems

1969 • 832 citations

Energetic optimization of ion conduction rate by the K+ selectivity filter

2001 • 810 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

Configurations of Polypeptide Chains With Favored Orientations Around Single Bonds

1951 • 778 citations

Energetics of ion conduction through the K+ channel

2001 • 768 citations

Structural Mechanisms for Domain Movements in Proteins

1994 • 741 citations

Light-Induced Structural Changes in Photosynthetic Reaction Center: Implications for Mechanism of Electron-Proton Transfer

1997 • 723 citations

Protein Data Bank (PDB): Database of Three-Dimensional Structural Information of Biological Macromolecules

1998 • 717 citations

A large-conductance mechanosensitive channel in E. coli encoded by mscL alone

1994 • 701 citations

Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity

1999 • 701 citations

Nobel lecture. The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis.

1989 • 634 citations

Structure of MsbA from E. coli : A Homolog of the Multidrug Resistance ATP Binding Cassette (ABC) Transporters

2001 • 626 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1989 • 615 citations

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with β-branched residues at neighboring positions

2000 • 588 citations

Helical Membrane Protein Folding, Stability, and Evolution

2000 • 585 citations

Proton Transfer Pathways in Bacteriorhodopsin at 2.3 Angstrom Resolution

1998 • 584 citations

Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors

2001 • 557 citations

Helix to helix packing in proteins

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Structure of the Light-Driven Chloride Pump Halorhodopsin at 1.8 Å Resolution

2000 • 531 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1990 • 514 citations

Nicotinic acetylcholine receptor at 4.6 Å resolution: transverse tunnels in the channel 1 1Edited by J. Karn

1999 • 487 citations

Specification of Subunit Assembly by the Hydrophilic Amino-Terminal Domain of the Shaker Potassium Channel

1992 • 449 citations

Hydrophobic moments and protein structure

1982 • 434 citations

Allosteric Receptors after 30 Years

1998 • 430 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

Structure of the Escherichia coli Fumarate Reductase Respiratory Complex

1999 • 405 citations

Energetic and Spatial Parameters for Gating of the Bacterial Large Conductance Mechanosensitive Channel, MscL

1999 • 394 citations

Presynaptic A-current based on heteromultimeric K+ channels detected in vivo

1993 • 379 citations

Electrostatic interactions of S4 voltage sensor in shaker K+ channel

1995 • 366 citations

The gating mechanism of the large mechanosensitive channel MscL

2001 • 350 citations

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications

2000 • 336 citations

Structure of fumarate reductase from Wolinella succinogenes at 2.2 Å resolution

1999 • 332 citations

Helix packing in membrane proteins

1997 • 324 citations

Hydrophobic Organization of Membrane Proteins

1989 • 316 citations

Structure of the Cytoplasmic β Subunit--T1 Assembly of Voltage-Dependent K ⁺ Channels

2000 • 315 citations

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1995 • 304 citations

Crystal structure of the tetramerization domain of the Shaker potassium channel

1998 • 303 citations

The Properties of Proteins in Nonaqueous Solvents

1963 • 290 citations

MECHANOSENSITIVE CHANNELS OFESCHERICHIA COLI:The MscL Gene, Protein, and Activities

1997 • 287 citations

Helix Packing in Polytopic Membrane Proteins: Role of Glycine in Transmembrane Helix Association

1999 • 287 citations

Internal packing of helical membrane proteins

2000 • 260 citations

Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli

1997 • 251 citations

Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes

1988 • 247 citations

pH-Dependent Gating in the Streptomyces lividans K⁺ Channel

1998 • 237 citations

Electrostatic calculations for an ion channel. I. Energy and potential profiles and interactions between ions

1978 • 236 citations

Structural Models of the MscL Gating Mechanism

2001 • 213 citations

Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits

1997 • 207 citations

THE BACTERIAL PHOTOSYNTHETIC REACTION CENTER AS A MODEL FOR MEMBRANE PROTEINS

1989 • 204 citations

Specificity and promiscuity in membrane helix interactions

1994 • 199 citations

Structure of the KcsA channel intracellular gate in the open state.

2001 • 196 citations

One face of a transmembrane helix is crucial in mechanosensitive channel gating

1998 • 194 citations

Lipid bilayer structure

2000 • 194 citations

Hydrophilicity of a Single Residue within MscL Correlates with Increased Channel Mechanosensitivity

1999 • 191 citations

Molecular recognition and assembly sequences involved in the subfamily-specific assembly of voltage-gated K+ channel subunit proteins

1995 • 188 citations

Kvβ1 Subunit Binding Specific for Shaker-Related Potassium Channel α Subunits

1996 • 183 citations

Ion Channels, Permeation, and Electrostatics: Insight into the Function of KcsA

2000 • 164 citations

Architecture of helix bundle membrane proteins: An analysis of cytochrome c oxidase from bovine mitochondria

1997 • 153 citations

Three-Dimensional Structure of a Voltage-Gated Potassium Channel at 2.5 nm Resolution

2001 • 141 citations

Interaction of transmembrane helices by a knobs-into-holes packing characteristic of soluble coiled coils

1998 • 134 citations

The Binding Site of Acetylcholine Receptor as Visualized in the X-Ray Structure of a Complex between α-Bungarotoxin and a Mimotope Peptide

2001 • 129 citations

The importance of aquaporin water channel protein structures

2000 • 129 citations

Contributions of the Different Extramembranous Domains of the Mechanosensitive Ion Channel MscL to Its Response to Membrane Tension

2000 • 105 citations

Site-Directed Spin-Labeling Analysis of Reconstituted Mscl in the Closed State

2001 • 103 citations

Non-α-helical elements modulate polytopic membrane protein architecture11Edited by G. Von Heijne

2001 • 101 citations

Hanging Gondola Structure of the T1 Domain in a Voltage-Gated K⁺ Channel

2000 • 100 citations

Helical membrane proteins: diversity of functions in the context of simple architecture

2001 • 86 citations

Helix packing angle preferences

1997 • 81 citations

Theoretical perspectives on ion-channel electrostatics: continuum and microscopic approaches

1992 • 77 citations

Comparing and Contrasting Escherichia coliand Mycobacterium tuberculosis Mechanosensitive Channels (MscL)

2000 • 66 citations

Effects of Protein Stabilizing Agents on Thermal Backbone Motions: A Disulfide Trapping Study

1996 • 66 citations

K+ channels lacking the 'tetramerization' domain: implications for pore structure.

1999 • 62 citations

Stoichiometry of the Large Conductance Bacterial Mechanosensitive Channel of E. coli. A Biochemical Study

1999 • 54 citations

Channel gate! Tension, leak and disclosure

1999 • 49 citations

Gating of voltage-dependent potassium channels

2001 • 48 citations

‘Feeling the pressure’: structural insights into a gated mechanosensitive channel

1999 • 46 citations

Structure of Ligand-Gated Ion Channels: Critical Assessment of Biochemical Data Supports Novel Topology

2001 • 44 citations

Crystallographic Analyses of Ion Channels: Lessons and Challenges

2000 • 44 citations

Atomic structure of a glycerol channel and implications for substrate permeation in aqua(glycero)porins

2001 • 42 citations

A New Twist in the Saga of Charge Movement in Voltage-Dependent Ion Channels

2000 • 39 citations

New structures of allosteric proteins revealing remarkable conformational changes

1996 • 36 citations

Conversion of Phospholamban into a Soluble Pentameric Helical Bundle

2001 • 33 citations

Riding the wave: structural and energetic principles of helical membrane proteins

2000 • 33 citations

Allosteric enzymes as models for chemomechanical energy transducing assemblies

1996 • 25 citations

Toward a High-Resolution Structure of Phospholamban: Design of Soluble Transmembrane Domain Mutants

2000 • 23 citations

Taking Apart the Gating of Voltage-Gated K+ Channels

2000 • 21 citations

Electromechanical Coupling Model of Gating the Large Mechanosensitive Ion Channel (MscL) of Escherichia coli by Mechanical Force

1998 • 20 citations

Thiol modification of diacylglycerol kinase: dependence upon site membrane disposition and reagent hydrophobicity

2000 • 13 citations

The Bacterial Photosynthetic Reaction Center As A Model For Membrane-Proteins

1989 • 5 citations