The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses

The Hippocampus as a Cognitive Map

1978 • 8,087 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

The Medial Temporal Lobe Memory System

1991 • 3,239 citations

Memory: a contribution to experimental psychology.

2013 • 2,567 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

1999 • 1,694 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Synaptic tagging and long-term potentiation

1997 • 1,689 citations

Molecular Biology of Learning: Modulation of Transmitter Release

1982 • 1,534 citations

An analysis of the end‐plate potential recorded with an intra‐cellular electrode

1951 • 1,389 citations

Cognitive Neuroscience and the Study of Memory

1998 • 1,294 citations

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

1997 • 1,228 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

1994 • 889 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

Structural Changes Accompanying Memory Storage

1993 • 851 citations

MORPHOLOGICAL AND FUNCTIONAL PROPERTIES OF IDENTIFIED NEURONS IN THE ABDOMINAL GANGLION OF APLYSIA CALIFORNICA

1967 • 806 citations

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

1986 • 767 citations

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

1990 • 741 citations

Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

1997 • 738 citations

Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†

1976 • 694 citations

Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones

1982 • 658 citations

A Cellular Mechanism of Classical Conditioning in Aplysia : Activity-Dependent Amplification of Presynaptic Facilitation

1983 • 620 citations

Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice

1996 • 594 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

1995 • 575 citations

Presynaptic facilitation revisited: state and time dependence

1996 • 555 citations

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

1993 • 549 citations

MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

1997 • 548 citations

Neuronal Correlates of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 529 citations

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia

1994 • 528 citations

Synaptic Facilitation and Behavioral Sensitization in Aplysia : Possible Role of Serotonin and Cyclic AMP

1976 • 515 citations

A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis

1999 • 510 citations

Long-Term Sensitization of a Defensive Withdrawal Reflex in Aplysia

1973 • 493 citations

Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.

1994 • 488 citations

Abolition of Long-Term Stability of New Hippocampal Place Cell Maps by NMDA Receptor Blockade

1998 • 485 citations

Neuronal Mechanisms of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 477 citations

Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin

2001 • 464 citations

The Croonian lecture.—La fine structure des centres nerveux

1894 • 464 citations

Gating of CaMKII by cAMP-Regulated Protein Phosphatase Activity During LTP

1998 • 452 citations

Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 427 citations

Cellular neurophysiological approaches in the study of learning.

1968 • 403 citations

CREB and the formation of long-term memory

1996 • 399 citations

Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia.

1980 • 380 citations

Cellular basis of behavior: An introduction to behavioral neurobiology.

1976 • 379 citations

Regulation of Hippocampal Transmitter Release During Development and Long-Term Potentiation

1995 • 379 citations

Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia

1992 • 377 citations

Expression Mechanisms Underlying NMDA Receptor‐Dependent Long‐Term Potentiation

1999 • 374 citations

Presynaptic Facilitation as a Mechanism for Behavioral Sensitization in Aplysia

1976 • 369 citations

Changes in reliability of synaptic function as a mechanism for plasticity

1994 • 367 citations

Restricted and Regulated Overexpression Reveals Calcineurin as a Key Component in the Transition from Short-Term to Long-Term Memory

1998 • 365 citations

Differential Classical Conditioning of a Defensive Withdrawal Reflex in Aplysia californica

1983 • 364 citations

CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation

1998 • 363 citations

Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia.

1980 • 363 citations

Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia

1997 • 359 citations

A Quarter of a Century of Place Cells

1996 • 356 citations

Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

1998 • 355 citations

Activation of cAMP-Responsive genes by stimuli that produce long-term facilitation in aplysia sensory neurons

1993 • 353 citations

GENE DISCOVERY INDROSOPHILA: New Insights for Learning and Memory

1998 • 344 citations

Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in Aplysia participate in the storage of long-term memory for sensitization

1985 • 334 citations

A Quantal Analysis of the Synaptic Depression Underlying Habituation of the Gill-Withdrawal Reflex in Aplysia

1974 • 313 citations

Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia

1992 • 313 citations

Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons.

1988 • 291 citations

Long-Term Habituation of a Defensive Withdrawal Reflex in Aplysia

1972 • 286 citations

Depletion of serotonin in the nervous system of Aplysia reduces the behavioral enhancement of gill withdrawal as well as the heterosynaptic facilitation produced by tail shock

1989 • 283 citations

Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+channels of Aplysia sensory neurones in cell-free membrane patches

1985 • 265 citations

cAMP Evokes Long-Term Facilitation in Aplysia Sensory Neurons That Requires New Protein Synthesis

1988 • 265 citations

Silent Synapses Speak Up

1997 • 253 citations

Local protein synthesis and its role in synapse-specific plasticity

2000 • 248 citations

mRNA Localization in Neurons: A Multipurpose Mechanism?

1997 • 248 citations

Inhibitor of protein synthesis blocks longterm behavioral sensitization in the isolated gill‐withdrawal reflex of Aplysia

1989 • 240 citations

Mice Expressing Activated CaMKII Lack Low Frequency LTP and Do Not Form Stable Place Cells in the CA1 Region of the Hippocampus

1996 • 234 citations

Target-Dependent Structural Changes Accompanying Long-Term Synaptic Facilitation in Aplysia Neurons

1990 • 230 citations

Recruitment of New Sites of Synaptic Transmission During the cAMP-Dependent Late Phase of LTP at CA3–CA1 Synapses in the Hippocampus

1997 • 225 citations

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination.

1989 • 216 citations

Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia

1982 • 207 citations

Identified serotonergic neurons LCB1 and RCB1 in the cerebral ganglia of Aplysia produce presynaptic facilitation of siphon sensory neurons

1989 • 196 citations

Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons

1997 • 185 citations

Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia

1999 • 184 citations

Receptive fields and response properties of mechanoreceptor neurons innervating siphon skin and mantle shelf in Aplysia.

1974 • 183 citations

Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia

1992 • 181 citations

Cellular Analysis of Long-Term Habituation of the Gill-Withdrawal Reflex of Aplysia californica

1978 • 177 citations

Neuronal Controls of a Behavioral Response Mediated by the Abdominal Ganglion of Aplysia

1969 • 176 citations

Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization

1986 • 174 citations

Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica

1972 • 173 citations

Functioning of identified neurons and synapses in abdominal ganglion of Aplysia in absence of protein synthesis.

1971 • 172 citations

A cell-biological approach to learning

1978 • 170 citations

L-glutamate may be the fast excitatory transmitter of Aplysia sensory neurons.

1993 • 161 citations

Cyclic AMP induces functional presynaptic boutons in hippocampal CA3–CA1 neuronal cultures

1999 • 157 citations

Time course of structural changes at identified sensory neuron synapses during long-term sensitization in Aplysia

1989 • 150 citations

Behavioral biology of Aplysia : a contribution to the comparative study of opisthobranch molluscs

1979 • 127 citations

Parallel Instabilities of Long-Term Potentiation, Place Cells, and Learning Caused by Decreased Protein Kinase A Activity

2000 • 126 citations

Metamorphosis of Aplysia californica in Laboratory Culture

1974 • 126 citations

Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. I. Identification and characterization.

1981 • 125 citations

Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. II. Identified neurons produce heterosynaptic facilitation contributing to behavioral sensitization.

1981 • 121 citations

Facilitatory transmitters and cAMP can modulate accommodation as well as transmitter release in Aplysia sensory neurons: Evidence for parallel processing in a single cell

1986 • 119 citations

Time, love, memory: a great biologist and his quest for the origins of behavior

1999 • 117 citations

Contribution of individual mechanoreceptor sensory neurons to defensive gill-withdrawal reflex in Aplysia

1978 • 107 citations

Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.

1966 • 107 citations

A Common Presynaptic Locus for the Synaptic Changes Underlying Short-term Habituation and Sensitization of the Gill-withdrawal Reflex in Aplysia

1976 • 99 citations

Synapse Specificity and Long-Term Information Storage

1997 • 99 citations

Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica

1972 • 97 citations

Cotransformation and gene targeting in mouse embryonic stem cells.

1991 • 77 citations

Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2

2000 • 75 citations

Sensitization in Aplysia : Restoration of Transmission in Synapses Inactivated by Long-Term Habituation

1979 • 59 citations

EFFECTS OF PUROMYCIN, ACETOXYCYCLOHEXIMIDE AND ACTINOMYCIN D ON PROTEIN SYNTHESIS IN GOLDFISH BRAIN*

1966 • 52 citations

Stimulus-response relations and stability of mechanoreceptor and motor neurons mediating defensive gill-withdrawal reflex in Aplysia

1978 • 50 citations

ELECTROPHYSIOLOGICAL PROPERTIES OF AN ARCHICORTICAL NEURON

1961 • 43 citations

Ultrastructural Plasticity of Excitatory Synapses

1997 • 22 citations

Deleted Work

1955 • 0 citations