Structural Determinants of Fast Desensitization and Desensitization–Deactivation Coupling in GABA_AReceptors

GABA_A Receptor Channels

1994 • 1,948 citations

Which GABAA-receptor subtypes really occur in the brain?

1996 • 1,183 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors

1998 • 880 citations

Transmitter timecourse in the synaptic cleft: its role in central synaptic function

1996 • 599 citations

Desensitized states prolong GABAA channel responses to brief agonist pulses

1995 • 592 citations

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1995 • 535 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

The impact of receptor desensitization on fast synaptic transmission

1996 • 478 citations

Quaternary Structure of the Native GABA_A Receptor Determined by Electron Microscopic Image Analysis

1994 • 423 citations

Stoichiometry of a Recombinant GABA_AReceptor

1996 • 423 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit

1997 • 402 citations

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1995 • 304 citations

θ, a novel γ-aminobutyric acid type A receptor subunit

1999 • 299 citations

Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.

1996 • 285 citations

GABA_A receptor subunit γ2 and δ subtypes confer unique kinetic properties on recombinant GABA_A receptor currents in mouse fibroblasts

1999 • 272 citations

How quickly can GABAA receptors open?

1994 • 249 citations

A Point Mutation in the Glutamate Binding Site Blocks Desensitization of AMPA Receptors

1998 • 236 citations

Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.

1989 • 225 citations

A Novel Class of GABAA Receptor Subunit in Tissues of the Reproductive System

1997 • 224 citations

Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

1997 • 221 citations

Developmental Changes of Inhibitory Synaptic Currents in Cerebellar Granule Neurons: Role of GABA_AReceptor α6 Subunit

1996 • 218 citations

The Location of the Gate in the Acetylcholine Receptor Channel

1998 • 196 citations

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.

1996 • 193 citations

Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the .alpha.-Subunit

1995 • 179 citations

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

1995 • 174 citations

N-Terminal Domains in the NR2 Subunit Control Desensitization of NMDA Receptors

1998 • 164 citations

Homomeric rho 1 GABA channels: activation properties and domains.

1994 • 139 citations

Single channel properties of recombinant GABA_A receptors containing γ2 or δ subtypes expressed with α1 and β3 subtypes in mouse L929 Cells

1997 • 136 citations

Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes.

1993 • 130 citations

Distinct Deactivation and Desensitization Kinetics of Recombinant GABAA Receptors

1996 • 119 citations

Channel opening locks agonist onto the GABAC receptor

1999 • 115 citations

Assembly of GABAA receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate/marker gene technique

1993 • 110 citations

Glycine-Independent NMDA Receptor Desensitization: Localization of Structural Determinants

1998 • 100 citations

Multiphasic desensitization of the GABAA receptor in outside-out patches

1994 • 93 citations

Properties of GABA_AReceptors Underlying Inhibitory Synaptic Currents in Neocortical Pyramidal Neurons

1997 • 84 citations

GABAA Receptor Assembly

2000 • 73 citations

Identification of Residues within GABA_AReceptor α Subunits That Mediate Specific Assembly with Receptor β Subunits

2000 • 72 citations

Recombinant GABAA receptor desensitization: the role of the gamma 2 subunit and its physiological significance.

1996 • 59 citations

Expression of Functional GABA A Receptors in Transfected L929 Cells Isolated by Immunomagnetic Bead Separation

1997 • 53 citations

Mutating the highly conserved second membrane-spanning region 9' leucine residue in the alpha(1) or beta(1) subunit produces subunit-specific changes in the function of human alpha(1)beta(1) gamma-aminobutyric Acid(A) receptors.

2000 • 24 citations

Acceleration of GABA-dependent desensitization by mutating threonine 266 to alanine of the α6 subunit of rat GABAA receptors

1995 • 15 citations

Deleted Work

1955 • 0 citations