Transient neuromotor phenotype in transgenic spastic mice expressing low levels of glycine receptor β‐subunit: an animal model of startle disease

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain.

1991 • 548 citations

Mutations in the α1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia

1993 • 540 citations

Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations

1998 • 448 citations

Identification of a gephyrin binding motif on the glycine receptor β subunit

1995 • 410 citations

Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

1988 • 388 citations

Glycine receptor heterogeneity in rat spinal cord during postnatal development.

1988 • 383 citations

Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control

1990 • 360 citations

Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord.

1984 • 335 citations

Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes.

1990 • 272 citations

Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor

1990 • 237 citations

Assessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred mouse strains and F1 hybrids: Implications of genetic background for single gene and quantitative trait loci analyses

1997 • 216 citations

Glycine receptor β–subunit gene mutation in spastic mouse associated with LINE–1 element insertion

1994 • 208 citations

A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor in the spasmodic mouse

1994 • 191 citations

Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor.

1990 • 189 citations

The spastic mouse: Aberrant splicing of glycine receptor β subunit mRNA caused by intronic insertion of Ll element

1994 • 185 citations

STARTLE DISEASE OR HYPEREKPLEXIA FURTHER DELINEATION OF THE SYNDROME

1980 • 185 citations

Assembly of the inhibitory glycine receptor: Identification of amino acid sequence motifs governing subunit stoichiometry

1993 • 183 citations

Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: identification of amino acid residues involved in taurine activation.

1992 • 177 citations

Hyperexplexia

1966 • 173 citations

Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia.

1994 • 168 citations

Structure and function of inhibitory glycine receptors

1992 • 162 citations

Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptor

1989 • 151 citations

Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the α₁ subunit of the inhibitory glycine receptor

1994 • 141 citations

Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant.

1994 • 136 citations

Targeting of Glycine Receptor Subunits to Gephyrin-Rich Domains in Transfected Human Embryonic Kidney Cells

1995 • 132 citations

Isoform-selective deficit of glycine receptors in the mouse mutant spastic

1992 • 125 citations

The glycine receptor deficiency of the mutant mouse spastic: evidence for normal glycine receptor structure and localization

1986 • 125 citations

Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor.

1994 • 120 citations

Glycine receptor alteration in the mutant mouse spastic

1982 • 117 citations

A frameshift mutation in the mouse α₁ glycine receptor gene (Gira1) results in progressive neurological symptoms and juvenile death

1994 • 117 citations

Startle disease, or hyperekplexia: Response to clonazepam and assignment of the gene (STHE) to chromosome 5q by linkage analysis

1992 • 115 citations

Point mutation of glycine receptor α1 subunit in the spasmodic mouse affects agonist responses

1994 • 98 citations

Solubilization of the glycine receptor from rat spinal cord

1981 • 81 citations

Hyperekplexia

1983 • 61 citations

Hereditary Stiff-Baby Syndrome

1981 • 59 citations

Studies of Porcine and Human Sperm Suggesting a Role for a Sperm Glycine Receptor/CIChannel in the Zona Pellucida-Initiated Acrosome Reaction1

1995 • 55 citations

Expression of inhibitory glycine receptors in postnatal rat cerebral cortex

1993 • 48 citations

Low level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic mice.

1996 • 46 citations

Startle disease or hyperekplexia: Adolescent onset and response to valproate

1989 • 41 citations

Immunochemical Identification of the Glycine Receptor/Cl−Channel in Porcine Sperm

1996 • 30 citations