Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin

1998 • 846 citations

Synaptic Activation Causes the mRNA for the IEG Arc to Localize Selectively near Activated Postsynaptic Sites on Dendrites

1998 • 807 citations

GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton

1999 • 722 citations

Neuronal Polarity

1994 • 658 citations

Purification and characterization of phosphoinositide 3-kinase from rat liver.

1990 • 640 citations

Rho GTPases

1998 • 534 citations

Recruitment of functional GABAA receptors to postsynaptic domains by insulin

1997 • 531 citations

PDZ Proteins Organize Synaptic Signaling Pathways

1998 • 474 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons

1993 • 446 citations

Dual Requirement for Gephyrin in Glycine Receptor Clustering and Molybdoenzyme Activity

1998 • 436 citations

Loss of Postsynaptic GABA_AReceptor Clustering in Gephyrin-Deficient Mice

1999 • 432 citations

Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

1998 • 426 citations

Identification of a gephyrin binding motif on the glycine receptor β subunit

1995 • 410 citations

Glycine receptor heterogeneity in rat spinal cord during postnatal development.

1988 • 383 citations

Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord

1996 • 383 citations

Purification by affinity chromatography of the glycine receptor of rat spinal cord.

1982 • 370 citations

Distribution of glycine receptors at central synapses: an immunoelectron microscopy study.

1985 • 358 citations

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

1998 • 353 citations

The Insulin Receptor Tyrosine Kinase Substrate p58/53 and the Insulin Receptor Are Components of CNS Synapses

1999 • 326 citations

PDZs and Receptor/Channel Clustering: Rounding Up the Latest Suspects

1996 • 322 citations

Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein

1992 • 307 citations

The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

1996 • 293 citations

Mechanisms of GABA and glycine depolarization‐induced calcium transients in rat dorsal horn neurons.

1994 • 278 citations

Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin

2000 • 273 citations

The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton

1995 • 273 citations

The 93-kDa glycine receptor-associated protein binds to tubulin.

1991 • 268 citations

Glycine-receptor activation is required for receptor clustering in spinal neurons

1998 • 267 citations

p21-Activated protein kinase: a crucial component of morphological signaling?

1999 • 261 citations

Postsynaptic Scaffolds of Excitatory and Inhibitory Synapses in Hippocampal Neurons: Maintenance of Core Components Independent of Actin Filaments and Microtubules

2000 • 243 citations

Altered synaptic clustering of GABA_A receptors in mice lacking dystrophin (mdx mice)

1999 • 226 citations

gamma-Aminobutyric acid-containing terminals can be apposed to glycine receptors at central synapses

1987 • 224 citations

Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ

1999 • 220 citations

Acetylcholine receptor gene expression at the developing neuromuscular junction.

1995 • 215 citations

The neurobiology of Duchenne muscular dystrophy: learning lessons from muscle?

2000 • 209 citations

Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor

1986 • 207 citations

Profilins as regulators of actin dynamics

1997 • 205 citations

Colocalization of gephyrin and GABA_A‐receptor subunits in the rat retina

1995 • 190 citations

The Mr 93,000 polypeptide of the postsynaptic glycine receptor complex is a peripheral membrane protein

1987 • 187 citations

Interaction of RAFT1 with Gephyrin Required for Rapamycin-Sensitive Signaling

1999 • 186 citations

The γ-aminobutyric acid type A receptor (GABA _A R)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse

2000 • 177 citations

Clustering of Gephyrin at GABAergic but Not Glutamatergic Synapses in Cultured Rat Hippocampal Neurons

1996 • 175 citations

Binding of the GABA_A Receptor‐Associated Protein (GABARAP) to Microtubules and Microfilaments Suggests Involvement of the Cytoskeleton in GABARAPGABA_A Receptor Interaction

2000 • 156 citations

The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells

1999 • 156 citations

Developmental Loss of GABA‐ and Glycine‐induced Depolarization and Ca²⁺ Transients in Embryonic Rat Dorsal Horn Neurons in Culture

1994 • 155 citations

Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptor

1989 • 151 citations

Purification and characterization of the glycine receptor of pig spinal cord

1985 • 148 citations

Interactions of Drebrin and Gephyrin with Profilin

1998 • 145 citations

Inhibitory neurotransmission in rat spinal cord: co-localization of glycine- and GABAA-receptors at GABAergic synaptic contacts demonstrated by triple immunofluorescence staining

1994 • 143 citations

The protein MAP-1B links GABAC receptors to the cytoskeleton at retinal synapses

1999 • 135 citations

Targeting of Glycine Receptor Subunits to Gephyrin-Rich Domains in Transfected Human Embryonic Kidney Cells

1995 • 132 citations

Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity

1997 • 130 citations

Identification and Characterization of hPEM-2, a Guanine Nucleotide Exchange Factor Specific for Cdc42

1999 • 123 citations

Dynamic actin structures stabilized byprofilin.

1994 • 122 citations

Dendritic and Postsynaptic Localizations of Glycine Receptor α Subunit mRNAs

1997 • 105 citations

The stimulation of the phosphorylation of ribosomal protein S6 by cycloheximide and puromycin

1974 • 102 citations

Formation of the neuromuscular junction

1999 • 100 citations

Strychnine-sensitive stabilization of postsynaptic glycine receptor clusters

1998 • 95 citations

Synaptic Control of Glycine and GABA_AReceptors and Gephyrin Expression in Cultured Motoneurons

1999 • 94 citations

Crystal Structure of the Gephyrin-related Molybdenum Cofactor Biosynthesis Protein MogA from Escherichia coli

2000 • 86 citations

Glycosyltransferase and sialic acid levels of normal and transformed cells

1973 • 85 citations

Diversity and phylogeny of gephyrin: Tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins

2000 • 84 citations

Neural roles of immunophilins and their ligands

1997 • 82 citations

Hydrophobic Interactions Mediate Binding of the Glycine Receptor β‐Subunit to Gephyrin

1999 • 81 citations

Localization of the clustering protein gephyrin at GABAergic synapses in the main olfactory bulb of the rat

1998 • 78 citations

Molybdenum cofactor of higher plants: biosynthesis and molecular biology

1997 • 69 citations

Expression of Glycine Receptor α Subunits and Gephyrin in Cultured Spinal Neurons

1996 • 65 citations

Synaptic Targeting of Ionotropic Neurotransmitter Receptors

1996 • 65 citations

Regulation of the MAPK family members: role of subcellular localization and architectural organization.

1999 • 55 citations

Postsynaptic gephyrin immunoreactivity exhibits a nearly one‐to‐one correspondence with gamma‐aminobutyric acid‐like immunogold‐labeled synaptic inputs to sympathetic preganglionic neurons

1995 • 52 citations

Glycine Receptors in Cultured Chick Sympathetic Neurons are Excitatory and Trigger Neurotransmitter Release

1997 • 52 citations

Sulfite oxidase deficiency

1989 • 49 citations

Assembly of signaling machinery at the postsynaptic membrane

1999 • 46 citations

Derepression of E. coli trp operon on interfamilial transfer

1977 • 42 citations

Incorporation of a gephyrin‐binding motif targets NMDA receptors to gephyrin‐rich domains in HEK 293 cells

1999 • 19 citations