Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

Crystal structures explain functional properties of two E. coli porins

1992 • 1,493 citations

An analysis of the end‐plate potential recorded with an intra‐cellular electrode

1951 • 1,389 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

Molecular Architecture and Electrostatic Properties of a Bacterial Porin

1991 • 700 citations

Mutations Affecting Internal TEA Blockade Identify the Probable Pore-Forming Region of a K ⁺ Channel

1991 • 634 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Transmembrane Protein Structure: Spin Labeling of Bacteriorhodopsin Mutants

1990 • 465 citations

Alteration of ionic selectivity of a K+ channel by mutation of the H5 region

1991 • 445 citations

Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit.

1983 • 412 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Exchange of Conduction Pathways Between Two Related K ⁺ Channels

1991 • 387 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein

1984 • 373 citations

The structure of ion channels in membranes of excitable cells

1989 • 368 citations

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1981 • 366 citations

The permeability of the endplate channel to organic cations in frog muscle.

1980 • 362 citations

A general method of site-specific mutagenesis using a modification of the Thermus aquaticus polymerase chain reaction

1989 • 321 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution

1992 • 268 citations

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

1992 • 238 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

The three-dimensional structure of P2 myelin protein.

1988 • 221 citations

Determination of transmembrane protein structure by disulfide cross-linking: the Escherichia coli Tar receptor.

1992 • 198 citations

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

1990 • 186 citations

[40] Novel sulfhydryl reagents

1977 • 179 citations

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1991 • 148 citations

Site-directed mutagenesis of colicin E1 provides specific attachment sites for spin labels whose spectra are sensitive to local conformation

1989 • 147 citations

In vitro synthesis, glycosylation, and membrane insertion of the four subunits of Torpedo acetylcholine receptor.

1981 • 147 citations

Structure of a bacterial sensory receptor. A site-directed sulfhydryl study.

1988 • 131 citations

Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel

1991 • 127 citations

Improved site-directed mutagenesis method using PCR

1991 • 120 citations

Analysis of the structure of a common cold virus, human rhinovirus 14, refined at a resolution of 3.0 Å

1990 • 116 citations

The reaction site of a non-competitive antagonist in the delta-subunit of the nicotinic acetylcholine receptor.

1986 • 104 citations

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

1990 • 104 citations

The noncompetitive blocker [³H]chlorpromazine labels segment M2 but not segment M 1 of the nicotinic acetylcholine receptor α‐subunit

1989 • 99 citations

Structural principles of parallel beta-barrels in proteins.

1988 • 92 citations

Open channel structure and ion binding sites of the nicotinic acetylcholine receptor channel

1989 • 86 citations

The transmembrane topology of the amino terminus of the alpha subunit of the nicotinic acetylcholine receptor

1991 • 84 citations

Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262.

1992 • 80 citations

The sidedness of the COOH terminus of the acetylcholine receptor δ subunit

1989 • 69 citations

Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region.

1992 • 63 citations

Transmembrane topography of the nicotinic acetylcholine receptor delta subunit.

1987 • 52 citations

Alteration of the pH-dependent ion selectivity of the colicin E1 channel by site-directed mutagenesis.

1990 • 50 citations

Role of a key cysteine residue in the gating of the acetylcholine receptor

1991 • 41 citations