Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

2009 • 2,107 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

2007 • 1,712 citations

Plasticity of CD4+ T Cell Lineage Differentiation

2009 • 1,476 citations

mTOR regulates memory CD8 T-cell differentiation

2009 • 1,473 citations

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

2007 • 1,443 citations

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

2009 • 1,425 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

2009 • 1,172 citations

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

2005 • 1,167 citations

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

2007 • 1,161 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

2010 • 1,064 citations

The Biology of Interleukin-2

2007 • 986 citations

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

2010 • 978 citations

New insights into the regulation of T cells by γc family cytokines

2009 • 947 citations

Effector and Memory CTL Differentiation

2006 • 908 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

2007 • 846 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

2006 • 770 citations

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

2010 • 721 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

2008 • 705 citations

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 • 693 citations

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

2007 • 661 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

A Two-Step Process for Thymic Regulatory T Cell Development

2008 • 615 citations

The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

2010 • 604 citations

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

2007 • 599 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

2007 • 579 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

2007 • 567 citations

Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

2009 • 563 citations

Nonredundant roles for Stat5a/b in directly regulating Foxp3

2007 • 561 citations

Shaping and reshaping CD8+ T-cell memory

2008 • 537 citations

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

2010 • 534 citations

Etiology of Type 1 Diabetes

2010 • 526 citations

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

2008 • 520 citations

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

2008 • 510 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

2009 • 493 citations

Heterogeneity of natural Foxp3 ⁺ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

2009 • 493 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

Regulatory Lymphocytes and Intestinal Inflammation

2009 • 489 citations

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

2005 • 473 citations

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses

2009 • 469 citations

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

2009 • 448 citations

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

2007 • 434 citations

Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γ _c Receptors

2005 • 434 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

Developmental regulation of Foxp3 expression during ontogeny

2005 • 418 citations

T cells use two directionally distinct pathways for cytokine secretion

2006 • 410 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

2008 • 405 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

Dicer-dependent microRNA pathway safeguards regulatory T cell function

2008 • 381 citations

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

2007 • 367 citations

Regulation and Functions of Blimp-1 in T and B Lymphocytes

2008 • 361 citations

Transcriptional repressor Blimp-1 regulates T cell homeostasis and function

2006 • 361 citations

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-6

2008 • 347 citations

Recent Advances in the Genetics of Autoimmune Disease

2008 • 329 citations

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

2009 • 324 citations

γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

2006 • 305 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells

2006 • 287 citations

Distinct IL-2 Receptor Signaling Pattern in CD4+CD25+ Regulatory T Cells

2004 • 279 citations

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

2009 • 267 citations

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor

2006 • 254 citations

A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells

2009 • 250 citations

IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development

2008 • 250 citations

Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

2005 • 237 citations

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion

2003 • 232 citations

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

2006 • 227 citations

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

2010 • 224 citations

Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains.

1995 • 206 citations

SIGNALING DOMAINS OF THE INTERLEUKIN 2 RECEPTOR

2001 • 205 citations

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25

2010 • 192 citations

CD4 ⁺ T cell regulation of CD25 expression controls development of short-lived effector CD8 ⁺ T cells in primary and secondary responses

2009 • 185 citations

Cutting Edge: Opposite Effects of IL-1 and IL-2 on the Regulation of IL-17+ T Cell Pool IL-1 Subverts IL-2-Mediated Suppression

2007 • 182 citations

Differential role of IL‐2R signaling for CD8⁺ T cell responses in acute and chronic viral infections

2007 • 179 citations

Cytokine-Dependent Blimp-1 Expression in Activated T Cells Inhibits IL-2 Production

2007 • 178 citations

Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells

2009 • 173 citations

Early IL-2 Production by Mouse Dendritic Cells Is the Result of Microbial-Induced Priming

2003 • 167 citations

Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7Rα–expressing cells

2007 • 166 citations

Differential regulation of T-cell growth by IL-2 and IL-15

2006 • 158 citations

PTEN inhibits IL-2 receptor-mediated expansion of CD4+CD25+ Tregs

2006 • 157 citations

Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells

2007 • 156 citations

IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response

2008 • 154 citations

The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation

2001 • 152 citations

Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival

2008 • 150 citations

The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells

2009 • 149 citations

T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8+ T Cell Homeostasis

2010 • 144 citations

Characterization of the thymic IL-7 niche in vivo

2009 • 140 citations

A Function for IL-7R for CD4+CD25+Foxp3+ T Regulatory Cells

2008 • 139 citations

IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508

2005 • 138 citations

A Synaptic Basis for Paracrine Interleukin-2 Signaling during Homotypic T Cell Interaction

2008 • 137 citations

Loss of Tolerance and Autoimmunity Affecting Multiple Organs inSTAT5A/5B-Deficient Mice

2003 • 130 citations

Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses

2002 • 128 citations

Distinct Roles for IL-2 and IL-15 in the Differentiation and Survival of CD8+ Effector and Memory T Cells

2010 • 122 citations

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

2008 • 119 citations

IL-2 and IL-15 receptor α-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells

2004 • 119 citations

The Proteasome Regulates Receptor-mediated Endocytosis of Interleukin-2

2001 • 116 citations

IL-15 Regulates CD8+ T Cell Contraction during Primary Infection

2006 • 112 citations

IL‐2 induces in vivo suppression by CD4⁺CD25⁺Foxp3⁺ regulatory T cells

2008 • 105 citations

IL‐2Rβ links IL‐2R signaling with Foxp3 expression

2007 • 101 citations

Initial Antigen Encounter Programs CD8+ T Cells Competent to Develop into Memory Cells That Are Activated in an Antigen-Free, IL-7- and IL-15-Rich Environment

2004 • 99 citations

Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis

2004 • 93 citations

The Production of IL-10 by Human Regulatory T Cells Is Enhanced by IL-2 through a STAT5-Responsive Intronic Enhancer in the IL-10 Locus

2008 • 90 citations

IL-15 Regulates Both Quantitative and Qualitative Features of the Memory CD8 T Cell Pool

2009 • 87 citations

Exploring regulatory mechanisms of CD8 ⁺ T cell contraction

2008 • 84 citations

Th3 Cells in Peripheral Tolerance. II. TGF-β-Transgenic Th3 Cells Rescue IL-2-Deficient Mice from Autoimmunity

2007 • 78 citations

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

2008 • 66 citations

STAT5 Is Essential for Akt/p70S6 Kinase Activity during IL-2-Induced Lymphocyte Proliferation

2007 • 58 citations

Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors

2003 • 58 citations

Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells

2006 • 56 citations

The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation: Importance of Two Widely Separated IL-2 Response Elements

2001 • 49 citations

Cutting Edge: Mechanism of Enhancement of In Vivo Cytokine Effects by Anti-Cytokine Monoclonal Antibodies

2008 • 44 citations

CD4+ CD25+ Foxp3+ T Regulatory Cells with Limited TCR Diversity in Control of Autoimmunity

2009 • 44 citations

γ _c deficiency precludes CD8 ⁺ T cell memory despite formation of potent T cell effectors

2010 • 32 citations

WIP is critical for T cell responsiveness to IL-2

2009 • 25 citations

Transgenic Expression of CTLA-4 Controls Lymphoproliferation in IL-2-Deficient Mice

2004 • 23 citations

Cutting Edge: Enhanced IL-2 Signaling Can Convert Self-Specific T Cell Response from Tolerance to Autoimmunity

2008 • 23 citations

Quantitative assessment concerning the contribution of IL-2R for superantigen-mediated T cell responses in vivo

2006 • 15 citations

Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice

2008 • 11 citations