Regulation and Functions of Blimp-1 in T and B Lymphocytes

Toll-Like Receptors

2003 • 6,127 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

2007 • 2,524 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

The immunological and genetic basis of inflammatory bowel disease

2003 • 1,766 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Cooperation of Toll-like receptor signals in innate immune defence

2007 • 1,320 citations

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

1992 • 1,259 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells

2004 • 1,014 citations

Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program

2002 • 1,000 citations

Blimp1 is a critical determinant of the germ cell lineage in mice

2005 • 999 citations

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 • 978 citations

Competence and competition: the challenge of becoming a long-lived plasma cell

2006 • 970 citations

A Critical Role for IL-21 in Regulating Immunoglobulin Production

2002 • 955 citations

BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control

2000 • 862 citations

Regulation of plasma-cell development

2005 • 826 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

2003 • 797 citations

Partners in transcription: NFAT and AP-1

2001 • 757 citations

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1994 • 752 citations

The SET-domain protein superfamily: protein lysine methyltransferases.

2005 • 737 citations

Control of B-cell responses by Toll-like receptors

2005 • 732 citations

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination

2006 • 725 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

2007 • 676 citations

Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6

2004 • 648 citations

IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells

2005 • 641 citations

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

2003 • 597 citations

The enemy within: keeping self-reactive T cells at bay in the periphery

2002 • 586 citations

BCL-6 protein is expressed in germinal-center B cells

1995 • 582 citations

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

1997 • 581 citations

Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling

2006 • 572 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Graded Expression of Interferon Regulatory Factor-4 Coordinates Isotype Switching with Plasma Cell Differentiation

2006 • 527 citations

Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

2006 • 511 citations

Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression

2004 • 500 citations

Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells

2006 • 457 citations

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

1999 • 456 citations

An epigenetic view of helper T cell differentiation

2003 • 429 citations

Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

2005 • 428 citations

Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells

2002 • 427 citations

Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response

2004 • 422 citations

Repression of c- myc Transcription by Blimp-1, an Inducer of Terminal B Cell Differentiation

1997 • 412 citations

Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland

2006 • 410 citations

Control of Apoptosis in the Immune System: Bcl-2, BH3-Only Proteins and More

2003 • 387 citations

Bone marrow is a major site of long-term antibody production after acute viral infection

1995 • 384 citations

Acetylation inactivates the transcriptional repressor BCL6

2002 • 383 citations

Transcriptional repressor Blimp-1 regulates T cell homeostasis and function

2006 • 361 citations

Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma

2006 • 360 citations

High affinity germinal center B cells are actively selected into the plasma cell compartment

2006 • 358 citations

Gene Repression by Pax5 in B Cells Is Essential for Blood Cell Homeostasis and Is Reversed in Plasma Cells

2006 • 354 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

Direct Repression of prdm1 by Bcl-6 Inhibits Plasmacytic Differentiation

2004 • 349 citations

Survival of long-lived plasma cells is independent of antigen [In Process Citation]

1998 • 346 citations

Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo

2000 • 337 citations

PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing

2004 • 335 citations

The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse

2005 • 332 citations

Transcriptional Repression by Blimp-1 (PRDI-BF1) Involves Recruitment of Histone Deacetylase

2000 • 328 citations

MTA3 and the Mi-2/NuRD Complex Regulate Cell Fate during B Lymphocyte Differentiation

2004 • 314 citations

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

2006 • 305 citations

The Role of Bone Marrow-Derived Stromal Cells in the Maintenance of Plasma Cell Longevity

2002 • 290 citations

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

1998 • 287 citations

BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts

1995 • 284 citations

IL-21 Counteracts the Regulatory T Cell-Mediated Suppression of Human CD4+ T Lymphocytes

2007 • 279 citations

The transcriptional programme of antibody class switching involves the repressor Bach2

2004 • 270 citations

Infection with a Helminth Parasite Prevents Experimental Colitis via a Macrophage-Mediated Mechanism

2007 • 269 citations

Early appearance of germinal center–derived memory B cells and plasma cells in blood after primary immunization

2005 • 254 citations

Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation.

1983 • 250 citations

Initiation of Plasma-Cell Differentiation Is Independent of the Transcription Factor Blimp-1

2007 • 249 citations

PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins

1999 • 248 citations

Pax5/BSAP Maintains the Identity of B Cells in Late B Lymphopoiesis

2001 • 246 citations

Regulation of Class-Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3-Kinase Signaling

2006 • 234 citations

The proto-oncogene c-myc in hematopoietic development and leukemogenesis

2002 • 227 citations

Suppression of Signal Transducer and Activator of Transcription 3–Dependent B Lymphocyte Terminal Differentiation by Bcl-6

2000 • 219 citations

Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow

2005 • 218 citations

Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas

2006 • 218 citations

Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family

1998 • 218 citations

A library of gene expression signatures to illuminate normal and pathological lymphoid biology

2006 • 217 citations

Loss of Pax5 Promotes Plasma Cell Differentiation

2006 • 216 citations

BLIMP-1 mediates extinction of major histocompatibility class II transactivator expression in plasma cells

2000 • 213 citations

Back to Central Tolerance

2004 • 202 citations

Role for Bcl-6 in the generation and maintenance of memory CD8[+] T cells

2002 • 192 citations

Repression of AP-1 Function: A Mechanism for the Regulation of Blimp-1 Expression and B Lymphocyte Differentiation by the B Cell Lymphoma-6 Protooncogene

2002 • 191 citations

Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.

1996 • 189 citations

Identification of Bach2 as a B-cell-specific partner for small Maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer

1998 • 189 citations

Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

2003 • 184 citations

Cytokine-Dependent Blimp-1 Expression in Activated T Cells Inhibits IL-2 Production

2007 • 178 citations

Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-10

2003 • 176 citations

The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling

2003 • 171 citations

The PR Domain of the Rb-binding Zinc Finger Protein RIZ1 Is a Protein Binding Interface and Is Related to the SET Domain Functioning in Chromatin-mediated Gene Expression

1998 • 167 citations

FoxO3a and BCR-ABL Regulatecyclin D2Transcription through a STAT5/BCL6-Dependent Mechanism

2004 • 162 citations

Inhibition of Th2 Differentiation and GATA-3 Expression by BCL-6

2003 • 161 citations

STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression

2005 • 161 citations

IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells

1998 • 155 citations

Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1

2007 • 150 citations

Plasmacytic Transcription Factor Blimp-1 Is Repressed by Bach2 in B Cells

2006 • 150 citations

Bcl6 Acts as an Amplifier for the Generation and Proliferative Capacity of Central Memory CD8+ T Cells

2004 • 144 citations

Increased Expression of CD27 on Activated Human Memory B Cells Correlates with Their Commitment to the Plasma Cell Lineage

2005 • 136 citations

B Lymphocyte-Induced Maturation Protein (Blimp)-1, IFN Regulatory Factor (IRF)-1, and IRF-2 Can Bind to the Same Regulatory Sites

2004 • 135 citations

Stages of Germinal Center Transit Are Defined by B Cell Transcription Factor Coexpression and Relative Abundance

2006 • 133 citations

Identification of a Functionally Impaired Positive Regulatory Domain I Binding Factor 1 Transcription Repressor in Myeloma Cell Lines

2003 • 131 citations

Reishi Polysaccharides Induce Immunoglobulin Production through the TLR4/TLR2-mediated Induction of Transcription Factor Blimp-1

2006 • 130 citations

Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K

2007 • 123 citations

Terminal differentiation of lymphocytes depends on Blimp-1

2007 • 122 citations

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals

2007 • 121 citations

Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding.

1992 • 119 citations

Modular Nature of Blimp-1 in the Regulation of Gene Expression during B Cell Maturation

2004 • 119 citations

Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. Anti-Ig down-regulates Fas expression of CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis.

1996 • 108 citations

PRDM1/Blimp‐1 is expressed in human B‐lymphocytes committed to the plasma cell lineage

2005 • 108 citations

Cutting Edge: Spontaneously Ig-Secreting B-1 Cells Violate the Accepted Paradigm for Expression of Differentiation-Associated Transcription Factors

2005 • 106 citations

B Lymphocyte Differentiation Induced by Lipopolysaccharide. III. Suppression of B Cell Maturation by Anti-Mouse Immunoglobulin Antibodies

1976 • 103 citations

Control of B Lymphocyte Apoptosis by the Transcription Factor NF-κB

2006 • 102 citations

Interleukin‐5 regulates genes involved in B‐cell terminal maturation

2006 • 102 citations

The Calcineurin Phosphatase Complex Modulates Immunogenic B Cell Responses

2006 • 101 citations

Repression of c-mycIs Necessary but Not Sufficient for Terminal Differentiation of B Lymphocytes In Vitro

2000 • 100 citations

The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer

1999 • 93 citations

Active Inhibition of Plasma Cell Development in Resting B Cells by Microphthalmia-associated Transcription Factor

2004 • 92 citations

Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene

2007 • 92 citations

The PPARγ Agonist Rosiglitazone Impairs Colonic Inflammation in Mice with Experimental Colitis

2007 • 90 citations

Differential Effect of B Lymphocyte–induced Maturation Protein (Blimp-1) Expression on Cell Fate during B Cell Development

1998 • 90 citations

Essential roles of a zebrafishprdm1/blimp1homolog in embryo patterning and organogenesis

2004 • 88 citations

B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion

2006 • 87 citations

Blimp-1 Specifies Neural Crest and Sensory Neuron Progenitors in the Zebrafish Embryo

2004 • 86 citations

Blimp-1 overcomes the block in IgM secretion in lipopolysaccharide / anti-μ F(ab′)2-co-stimulated B lymphocytes

1996 • 86 citations

PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma.

2006 • 84 citations

Development and Maintenance of a B220− Memory B Cell Compartment

2001 • 81 citations

The dichotomous role of IL-2: tolerance versus immunity

2006 • 81 citations

Repression of BCL-6 is required for the formation of human memory B cells in vitro

2007 • 80 citations

A Role for c-fos/Activator Protein 1 in B Lymphocyte Terminal Differentiation

2005 • 78 citations

ERK Signaling Is a Molecular Switch Integrating Opposing Inputs from B Cell Receptor and T Cell Cytokines to Control TLR4-Driven Plasma Cell Differentiation

2006 • 77 citations

Immunization-Induced Perturbation of Human Blood Plasma Cell Pool: Progressive Maturation, IL-6 Responsiveness, and High PRDI-BF1/BLIMP1 Expression Are Critical Distinctions between Antigen-Specific and Nonspecific Plasma Cells

2006 • 72 citations

B Lymphocyte Differentiation Induced by Lipopolysaccharide

1976 • 71 citations

Defined Blocks in Terminal Plasma Cell Differentiation of Common Variable Immunodeficiency Patients

2005 • 71 citations

Positive Regulatory Domain I Binding Factor 1 Silences Class II Transactivator Expression in Multiple Myeloma Cells

2001 • 69 citations

Regulatory events in early and late B-cell differentiation

2005 • 66 citations

Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction

2006 • 64 citations

ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells

2003 • 63 citations

Antigen-capturing Cells Can Masquerade as Memory B Cells

2003 • 61 citations

Low Activation Threshold As a Mechanism for Ligand-Independent Signaling in Pre-T Cells

2003 • 61 citations

Differential requirement for OBF-1 during antibody-secreting cell differentiation

2005 • 60 citations

Analysis of Transcription Factor Expression during Discrete Stages of Postnatal Thymocyte Differentiation

2004 • 56 citations

Evidence of abortive plasma cell differentiation in Hodgkin and Reed‐Sternberg cells of classical Hodgkin lymphoma

2005 • 54 citations

Characterization of the B lymphocyte-induced maturation protein-1 (Blimp-1) gene, mRNA isoforms and basal promoter

2000 • 54 citations

A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells

2003 • 53 citations

BLIMP‐1 is a target of cellular stress and downstream of the unfolded protein response

2006 • 52 citations

Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching.

2001 • 52 citations

Characterization of the PR domain of RIZ1 histone methyltransferase

2005 • 50 citations

Tracking the response of Xid B cells in vivo: TI-2 antigen induces migration and proliferation but Btk is essential for terminal differentiation

2001 • 47 citations

The B-Lymphocyte Maturation Promoting Transcription Factor BLIMP1/PRDI-BF1 Maps to D6S447 on Human Chromosome 6q21–q22.1 and the Syntenic Region of Mouse Chromosome 10

1996 • 46 citations

Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family

1999 • 46 citations

A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo

2006 • 45 citations

A Putative Silencer Element in the IL-5 Gene Recognized by Bcl6

2002 • 41 citations

Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching

2001 • 41 citations

Transcription factors that regulate memory in humoral responses

2006 • 41 citations

Human BSAP and BLIMP1 conform an autoregulatory feedback loop

2007 • 39 citations

The B Cell Antigen Receptor Controls AP-1 and NFAT Activity through Ras-Mediated Activation of Ral

2007 • 36 citations

Regulation of Terminal differentiation of Human B-Cells by IL-6

1995 • 32 citations

Blimp-1 is an essential component of the genetic program controlling development of the pectoral limb bud

2006 • 29 citations

Expression of the Bcl-2 family member A1 is developmentally regulated in T cells

1999 • 28 citations

Blimp-1; Immunoglobulin Secretion and the Switch to Plasma Cells

2005 • 26 citations

The tumor suppressor gene RIZ in cancer gene therapy (Review)

2002 • 25 citations

The KOX zinc finger genes: Genome wide mapping of 368 ZNF PAC clones with zinc finger gene clusters predominantly in 23 chromosomal loci are confirmed by human sequences annotated in EnsEMBL

2002 • 24 citations

B-lymphocyte-induced maturation protein-1 (Blimp-1) gene of torafugu (Takifugu rubripes)

2005 • 19 citations

Vav Proteins Regulate the Plasma Cell Program and Secretory Ig Production

2006 • 17 citations

Blimp‐1 is expressed in human and mouse T cell subsets and leads to loss of IL‐2 production and to defective proliferation

2006 • 17 citations

Balance of NF-kappaB and p38 MAPK is a determinant of radiosensitivity of the AML-2 and its doxorubicin-resistant cell lines

2007 • 17 citations

Mad1 is a transcriptional repressor of Bcl-6

2006 • 14 citations

Novel BLIMP1/PRDM1 gene mutations in B-cell lymphoma

2007 • 12 citations

Centrocytoid Plasma Cells of the Germinal Center

2005 • 10 citations

Coordination of upregulated XBP-1 and downregulated c-myc during myeloma cell differentiation induced by 2-methoxyestradiol

2007 • 9 citations