Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Cytokine control of memory T-cell development and survival

2003 • 885 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

T Cell Memory

2002 • 529 citations

Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes.

1993 • 352 citations

Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

1994 • 338 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

Cytokine-binding proteins: stimulating antagonists

1995 • 94 citations

Alterations in the amino-terminal third of mouse interleukin 2: effects on biological activity and immunoreactivity.

1986 • 61 citations

An anti-IL-2 antibody increases serum halflife and improves anti-tumor efficacy of human recombinant interleukin-2

1994 • 52 citations

Enhancement of anti-tumor activity of recombinant interleukin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2

1993 • 28 citations

Evidence of a Novel IL-2/15Rβ-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells

2004 • 25 citations