Differential role of IL‐2R signaling for CD8⁺ T cell responses in acute and chronic viral infections

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

2003 • 1,500 citations

Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

2003 • 1,466 citations

T Cell Anergy

2003 • 1,418 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

2002 • 986 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Helping the CD8+ T-cell response

2004 • 775 citations

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

2006 • 770 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

2005 • 598 citations

IL-2, Regulatory T Cells, and Tolerance

2004 • 566 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis

2001 • 517 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8 ⁺ memory T cell subsets

2004 • 466 citations

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

1991 • 460 citations

Memory Inflation: Continuous Accumulation of Antiviral CD8+ T Cells Over Time

2003 • 430 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

Duration of TCR Stimulation Determines Costimulatory Requirement of T Cells

1996 • 372 citations

Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy

2001 • 366 citations

Systematic Excision of Vector Sequences from the BAC-Cloned Herpesvirus Genome during Virus Reconstitution

1999 • 314 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

Nonmethylated CG Motifs Packaged into Virus-Like Particles Induce Protective Cytotoxic T Cell Responses in the Absence of Systemic Side Effects

2004 • 284 citations

Functional Properties and Lineage Relationship of CD8+ T Cell Subsets Identified by Expression of IL-7 Receptor α and CD62L

2005 • 273 citations

Ablation of CD8 and CD4 T Cell Responses by High Viral Loads

2003 • 266 citations

Four Distinct Patterns of Memory CD8 T Cell Responses to Chronic Murine Cytomegalovirus Infection

2006 • 240 citations

Normal clonal expansion but impaired Fasmediated cell death and anergy induction in interleukin‐2‐deficient mice

1995 • 234 citations

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion

2003 • 232 citations

Maintenance, Loss, and Resurgence of T Cell Responses During Acute, Protracted, and Chronic Viral Infections

2004 • 214 citations

Enrichment of Immediate-Early 1 (m123/pp89) Peptide-Specific CD8 T Cells in a Pulmonary CD62L^loMemory-Effector Cell Pool during Latent Murine Cytomegalovirus Infection of the Lungs

2000 • 211 citations

A Significant Number of Human Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes Detected by Tetramer Binding Do Not Produce Gamma Interferon

2000 • 201 citations

Regulation of mature T cell homeostasis

2005 • 191 citations

CD8 T Cells Control Cytomegalovirus Latency by Epitope-Specific Sensing of Transcriptional Reactivation

2006 • 177 citations

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

1995 • 172 citations

Genome-Wide Analysis Reveals a Highly Diverse CD8 T Cell Response to Murine Cytomegalovirus

2006 • 152 citations

A Mouse Model for Cytomegalovirus Infection

2001 • 147 citations

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene.

1995 • 145 citations

Recall Proliferation Potential of Memory CD8+ T Cells and Antiviral Protection

2005 • 134 citations

Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8 ⁺ T cell functions during chronic viral infection

2007 • 131 citations

Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses

2002 • 128 citations

Immune responses in the absence of costimulation: viruses know the trick.

1998 • 119 citations

Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system

1995 • 106 citations

Cutting Edge Commentary: Immune Responses in the Absence of Costimulation: Viruses Know the Trick

1998 • 99 citations

Tolerance induction by clonal deletion of CD4⁺8⁺ thymocytes in vitro does not require dedicated antigen‐presenting cells

1993 • 97 citations

IL-2 Induces a Competitive Survival Advantage in T Lymphocytes

2004 • 95 citations

IL-2 and autoimmune disease

2002 • 93 citations

Induction of protective cytotoxic T cells with viral proteins

1994 • 91 citations

Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4

1995 • 66 citations

Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors

2003 • 58 citations

High numbers of IL-2-producing CD8+ T cells during viral infection: correlation with stable memory development

2002 • 56 citations

Cutting Edge: Distinct Roles for T Help and CD40/CD40 Ligand in Regulating Differentiation of Proliferation-Competent Memory CD8+ T Cells

2004 • 49 citations

Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load.

2002 • 36 citations

The CD8 memory T cell subsystem: Integration of homeostatic signaling during migration

2005 • 31 citations