Etiology of Type 1 Diabetes

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases

2002 • 2,592 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

2010 • 2,149 citations

Factors Influencing the Composition of the Intestinal Microbiota in Early Infancy

2006 • 2,099 citations

ChIP–seq: advantages and challenges of a maturing technology

2009 • 2,002 citations

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

2009 • 1,923 citations

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

2008 • 1,853 citations

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

2009 • 1,699 citations

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

2007 • 1,567 citations

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

2007 • 1,426 citations

Understanding mechanisms underlying human gene expression variation with RNA sequencing

2010 • 1,303 citations

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

2009 • 1,110 citations

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

2009 • 972 citations

Multiple common variants for celiac disease influencing immune gene expression

2010 • 961 citations

A genome-wide association study of global gene expression

2007 • 954 citations

Rare Variants of IFIH1 , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

2009 • 952 citations

Redefining Chronic Viral Infection

2009 • 941 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

2010 • 797 citations

Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors

2007 • 757 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

2008 • 729 citations

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

2010 • 706 citations

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

2008 • 705 citations

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

2006 • 677 citations

Newly identified genetic risk variants for celiac disease related to the immune response

2008 • 669 citations

DNA methylation profiles in monozygotic and dizygotic twins

2009 • 666 citations

Analysis of islet inflammation in human type 1 diabetes

2008 • 659 citations

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

2009 • 647 citations

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

2010 • 646 citations

Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis

2008 • 634 citations

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

2008 • 582 citations

Orm family proteins mediate sphingolipid homeostasis

2010 • 580 citations

Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies

2008 • 560 citations

Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

2007 • 553 citations

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

2009 • 545 citations

A map of open chromatin in human pancreatic islets

2010 • 545 citations

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

2007 • 544 citations

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

2009 • 520 citations

Common variants at five new loci associated with early-onset inflammatory bowel disease

2009 • 479 citations

Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

2009 • 441 citations

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

2007 • 413 citations

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

2009 • 367 citations

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

2008 • 367 citations

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

2007 • 367 citations

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

2008 • 355 citations

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism

2006 • 354 citations

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

2003 • 345 citations

Role of PTPN22 in type 1 diabetes and other autoimmune diseases

2006 • 341 citations

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

2009 • 332 citations

Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus

2006 • 331 citations

Chromogranin A is an autoantigen in type 1 diabetes

2010 • 330 citations

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

2009 • 312 citations

Tissue-mediated control of immunopathology in coeliac disease

2009 • 301 citations

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

2010 • 300 citations

Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease

2009 • 287 citations

IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)

2009 • 287 citations

The methylome: approaches for global DNA methylation profiling

2008 • 281 citations

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

2009 • 273 citations

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

2009 • 267 citations

Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level

2004 • 262 citations

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

2009 • 260 citations

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

2009 • 255 citations

Clinical Applications of Diabetes Antibody Testing

2009 • 255 citations

The Genetics of Crohn's Disease

2009 • 252 citations

IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production

2009 • 237 citations

A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes

2008 • 204 citations

Successful oral tolerance induction in severe peanut allergy

2009 • 203 citations

Insulin as an autoantigen in NOD/human diabetes

2008 • 193 citations

Significant Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus

2008 • 188 citations

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

2009 • 186 citations

A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins

2001 • 185 citations

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing

2009 • 178 citations

Thymus-specific deletion of insulin induces autoimmune diabetes

2009 • 176 citations

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

2010 • 174 citations

Interferon-α initiates type 1 diabetes in nonobese diabetic mice

2008 • 169 citations

Humanized mouse models to study human diseases

2010 • 168 citations

Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

2008 • 165 citations

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

2009 • 164 citations

Type 1 diabetes genes and pathways shared by humans and NOD mice

2005 • 146 citations

Characterization of human epigenomes

2009 • 146 citations

Natural peptides selected by diabetogenic DQ8 and murine I-Ag7 molecules show common sequence specificity

2005 • 140 citations

Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in the General Population

2009 • 132 citations

Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA‐B and HLA‐A

2009 • 131 citations

Identification of a Molecular Signature in Human Type 1 Diabetes Mellitus Using Serum and Functional Genomics

2008 • 110 citations

Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease

2004 • 107 citations

Interferon alpha—a potential link in the pathogenesis of viral-induced type 1 diabetes and autoimmunity

2004 • 104 citations

Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13

2008 • 102 citations

Fine-Scale Variation and Genetic Determinants of Alternative Splicing across Individuals

2009 • 91 citations

Association ofCTLA4 polymorphism with regulatory T cell frequency

2005 • 88 citations

Cutting Edge: Polyinosinic:Polycytidylic Acid Boosts the Generation of Memory CD8 T Cells through Melanoma Differentiation-Associated Protein 5 Expressed in Stromal Cells

2010 • 87 citations

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition

2009 • 86 citations

The role of paracetamol in the pathogenesis of asthma

2009 • 85 citations

A Protective Role of the Environment in the Development of Type 1 Diabetes?

1991 • 82 citations

Effects of the multiple sclerosis associated −330 promoter polymorphism in IL2 allelic expression

2004 • 80 citations

Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes

2009 • 75 citations

No association of multiple type 2 diabetes loci with type 1 diabetes

2009 • 75 citations

Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus

2009 • 65 citations

Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes

2010 • 60 citations

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis

2010 • 60 citations

A virus–gene collaboration

2009 • 59 citations

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

2010 • 56 citations

Functionally Significant Differences in Expression of Disease-Associated IL-7 Receptor α Haplotypes in CD4 T Cells and Dendritic Cells

2010 • 54 citations

Functional islet‐specific Treg can be generated from CD4⁺CD25⁻ T cells of healthy and type 1 diabetic subjects

2009 • 48 citations

Enhanced selection of FoxP3 ⁺ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease

2009 • 46 citations

Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

2008 • 45 citations

Slc11a1Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens

2008 • 44 citations

Infection and autoimmunity

2008 • 34 citations

Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species

2008 • 29 citations

Chapter 2 CD3 Antibodies as Unique Tools to Restore Self-Tolerance in Established Autoimmunity

2008 • 25 citations

Genetic Risk Markers Related to Diabetes-Associated Autoantibodies in Young Patients with Type 1 Diabetes in Berlin, Germany

2010 • 20 citations

Regulation of IL-2 expression by transcription factor BACH2 in umbilical cord blood CD4+ T cells

2008 • 14 citations

Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus

1993 • 13 citations

Both central and peripheral tolerance mechanisms play roles in diabetes prevention in NOD-E transgenic mice

2008 • 11 citations

Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice

2010 • 8 citations

Translating Mucosal Antigen based Prevention of Autoimmune Diabetes to Human

2008 • 5 citations