Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 • 1,150 citations

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

1985 • 1,143 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Segregation of transferrin to a mildly acidic (pH 6.5) para-golgi compartment in the recycling pathway

1984 • 586 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

1983 • 558 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

The interleukin-2 receptor.

1991 • 354 citations

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

1994 • 342 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

The Interleukin 2 Receptor

1989 • 244 citations

Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation.

1981 • 232 citations

High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells.

1986 • 192 citations

Internalization and rapid recycling of macrophage Fc receptors tagged with monovalent antireceptor antibody: possible role of a prelysosomal compartment.

1984 • 176 citations

The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation.

1994 • 149 citations

The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes

1994 • 145 citations

Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited

1994 • 144 citations

Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention.

1994 • 144 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R.

1992 • 135 citations

An associated molecule, p64, with IL-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex.

1992 • 128 citations

Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells.

1994 • 111 citations

Expression of the IL-2 receptor γ chain on various populations in human peripheral blood

1994 • 104 citations

Autocrine growth stimulation of a human T-cell lymphoma line by interleukin 2.

1985 • 86 citations

Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain.

1992 • 83 citations

Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

1993 • 76 citations

Interleukin‐2 (IL‐2) receptor γ chain mutations in X‐linked severe combined immunodeficiency disease result in the loss of high‐affinity IL‐2 receptor binding

1994 • 70 citations

Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.

1994 • 68 citations

Receptor-mediated endocytosis of interleukin 2 in a human tumor T cell line. Degradation of interleukin 2 and evidence for the absence of recycling of interleukin receptors.

1986 • 64 citations

Down-regulation of high affinity interleukin 2 receptors in a human tumor T cell line. Interleukin 2 increases the rate of surface receptor decay.

1988 • 58 citations

Interleukin-2-induced tyrosine phosphorylation of Shc proteins correlates with factor-dependent T cell proliferation.

1994 • 50 citations

Co-internalization of the p55 and p70 subunits of the high-affinity human interleukin 2 receptor. Evidence for a stable ternary receptor complex.

1988 • 35 citations

Cyclosporin A inhibits the interleukin 2 receptor α chain gene transcription but not its cell surface expression: the α chain stability can explain this discrepancy

1990 • 34 citations

Cytokine Receptors in Congenital Hematopoietic Disease

1994 • 28 citations

Endocytosis of the β chain of interleukin‐2 receptor requires neither interleukin‐2 nor the γ chain

1994 • 23 citations

High-affinity interleukin 2 receptor alpha and beta chains are internalized and remain associated inside the cells after interleukin 2 endocytosis.

1992 • 22 citations

Autocrine growth of a human T-cell line is inhibited by cyclosporin A

1988 • 17 citations

Trafficking of interleukin 2 and transferrin in endosomal fractions of T lymphocytes

1994 • 16 citations

Murine T-lymphocyte proliferation induced by interleukin 2 correlates with a transient increase in p56lck kinase activity and the tyrosine phosphorylation of a 97-kDa protein.

1993 • 16 citations

Interleukin 2 receptor traffic in a murine cytolytic T cell line

1987 • 12 citations

Both the alpha and beta chains of high-affinity interleukin 2 receptors are located in intracellular vesicles when their ligand is endocytosed.

1993 • 8 citations