Shaping and reshaping CD8+ T-cell memory

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Effector and memory T-cell differentiation: implications for vaccine development

2002 • 1,757 citations

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

2007 • 1,712 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

2003 • 1,500 citations

Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

2003 • 1,466 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Molecular and Functional Profiling of Memory CD8 T Cell Differentiation

2002 • 962 citations

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

2005 • 919 citations

Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response Magnitude

2007 • 918 citations

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

2001 • 894 citations

Interleukin-10 determines viral clearance or persistence in vivo

2006 • 888 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

Memory CD8 T-Cell Differentiation during Viral Infection

2004 • 841 citations

Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

2007 • 824 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

Helping the CD8+ T-cell response

2004 • 775 citations

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

2006 • 770 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection

2004 • 653 citations

A Role for CD40 Expression on CD8 ⁺ T Cells in the Generation of CD8 ⁺ T Cell Memory

2002 • 629 citations

Maintaining the norm: T-cell homeostasis

2002 • 608 citations

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

2001 • 600 citations

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

2005 • 598 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

Programmed contraction of CD8+ T cells after infection

2002 • 586 citations

Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation

2005 • 586 citations

Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells

2002 • 584 citations

Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells

1999 • 580 citations

Signals required for programming effector and memory development by CD8⁺ T cells

2006 • 574 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Resolution of a chronic viral infection after interleukin-10 receptor blockade

2006 • 538 citations

Coordinate Regulation of Complex T Cell Populations Responding to Bacterial Infection

1998 • 535 citations

Virus-specific CD8+ T-cell memory determined by clonal burst size

1994 • 525 citations

Early Programming of T Cell Populations Responding to Bacterial Infection

2000 • 492 citations

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

2004 • 489 citations

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

2005 • 458 citations

Regulation of Antigen-Specific CD8 ⁺ T Cell Homeostasis by Perforin and Interferon-γ

2000 • 452 citations

Specific immunity to listeria monocytogenes in the absence of IFNγ

1995 • 432 citations

Interferon γ Is Required for Activation-induced Death of T Lymphocytes

2002 • 423 citations

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection

2007 • 415 citations

T cells and viral persistence: lessons from diverse infections

2005 • 407 citations

Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination

2005 • 382 citations

Cutting Edge: Increased Expression of Bcl-2 in Antigen-Specific Memory CD8+ T Cells

2000 • 355 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

Jump-starting the immune system: prime–boosting comes of age

2003 • 338 citations

CD8+ T cell contraction is controlled by early inflammation

2004 • 322 citations

Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection

2005 • 314 citations

Stimulation History Dictates Memory CD8 T Cell Phenotype: Implications for Prime-Boost Vaccination

2006 • 311 citations

Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection

1999 • 299 citations

Size Estimate of the αβ TCR Repertoire of Naive Mouse Splenocytes

2000 • 297 citations

Measuring the diaspora for virus-specific CD8⁺T cells

2001 • 288 citations

CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine

2003 • 279 citations

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells

2007 • 273 citations

Dynamic imaging of the immune system: progress, pitfalls and promise

2006 • 270 citations

Ablation of CD8 and CD4 T Cell Responses by High Viral Loads

2003 • 266 citations

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

2007 • 260 citations

Inflaming the CD8+ T Cell Response

2006 • 243 citations

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion

2003 • 232 citations

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

2003 • 229 citations

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

2001 • 228 citations

Generation of CD8 T Cell Memory Is Regulated by IL-12

2007 • 219 citations

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

2007 • 215 citations

Maintenance, Loss, and Resurgence of T Cell Responses During Acute, Protracted, and Chronic Viral Infections

2004 • 214 citations

Differential Sensitivity of Naive and Memory CD8+ T Cells to Apoptosis in Vivo

2002 • 204 citations

Innate Inflammatory Signals Induced by Various Pathogens Differentially Dictate the IFN-I Dependence of CD8 T Cells for Clonal Expansion and Memory Formation

2006 • 199 citations

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection

2006 • 186 citations

Critical Role for Alpha/Beta and Gamma Interferons in Persistence of Lymphocytic Choriomeningitis Virus by Clonal Exhaustion of Cytotoxic T Cells

2001 • 177 citations

Inverse correlation between IL‐7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation

2005 • 170 citations

Cutting Edge: CD8 T Cells Specific for Lymphocytic Choriomeningitis Virus Require Type I IFN Receptor for Clonal Expansion

2006 • 167 citations

Secondary memory CD8+ T cells are more protective but slower to acquire a central–memory phenotype

2006 • 166 citations

Programming, demarcating, and manipulating CD8⁺ T‐cell memory

2006 • 157 citations

Homeostatic control of lymphocyte survival: potential origins and implications

2002 • 157 citations

Development, trafficking, and function of memory T‐cell subsets

2006 • 153 citations

Developing and maintaining protective CD8⁺ memory T cells

2006 • 146 citations

Adjuvant Effect of IL-12: Conversion of Peptide Antigen Administration from Tolerizing to Immunizing for CD8+ T Cells In Vivo

1999 • 138 citations

Cutting Edge: Emergence of CD127high Functionally Competent Memory T Cells Is Compromised by High Viral Loads and Inadequate T Cell Help

2005 • 138 citations

Migration and differentiation of CD8⁺ T cells

2002 • 137 citations

Fully Functional Memory CD8 T Cells in the Absence of CD4 T Cells

2004 • 128 citations

Complex Memory T-Cell Phenotypes Revealed by Coexpression of CD62L and CCR7

2005 • 128 citations

Apoptosis and the homeostatic control of immune responses

2007 • 127 citations

T‐cell memory and recall responses to respiratory virus infections

2006 • 124 citations

Bim mediates apoptosis of CD127^lo effector T cells and limits T cell memory

2006 • 114 citations

Regulation of CD8+ T Cells Undergoing Primary and Secondary Responses to Infection in the Same Host

2003 • 111 citations

Manipulating the Rate of Memory CD8+ T Cell Generation after Acute Infection

2007 • 110 citations

Division of Labor with a Workforce of One: Challenges in Specifying Effector and Memory T Cell Fate

2007 • 109 citations

IL-7 Receptor Expression Levels Do Not Identify CD8+ Memory T Lymphocyte Precursors following Peptide Immunization

2005 • 103 citations

Intracellular staining for TNF and IFN-γ detects different frequencies of antigen-specific CD8+ T cells

2000 • 99 citations

Dynamic Regulation of IFN-γ Signaling in Antigen-Specific CD8+ T Cells Responding to Infection

2005 • 94 citations

Critical Role for Perforin-, Fas/FasL-, and TNFR1-Mediated Cytotoxic Pathways in Down-Regulation of Antigen-Specific T Cells during Persistent Viral Infection

2002 • 90 citations

Cutting Edge: Migration to Nonlymphoid Tissues Results in Functional Conversion of Central to Effector Memory CD8 T Cells

2007 • 87 citations

Direct Interferon-γ Signaling Dramatically Enhances CD4+ and CD8+ T Cell Memory

2007 • 87 citations

IL-12 and Type-I IFN Synergize for IFN-γ Production by CD4 T Cells, Whereas Neither Are Required for IFN-γ Production by CD8 T Cells afterListeria monocytogenesInfection

2007 • 85 citations

Quantification of Repertoire Diversity of Influenza-Specific Epitopes with Predominant Public or Private TCR Usage

2006 • 83 citations

TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions

2000 • 75 citations

Fas-dependent CD4⁺cytotoxic T-cell-mediated pathogenesis during virus infection

1996 • 72 citations

Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1)

2000 • 70 citations

Role of Bim in Regulating CD8⁺T-Cell Responses during Chronic Viral Infection

2006 • 69 citations

Role of Direct Effects of IFN-γ on T Cells in the Regulation of CD8 T Cell Homeostasis

2007 • 66 citations

Cutting Edge: Innate Immune Cells Contribute to the IFN-γ-Dependent Regulation of Antigen-Specific CD8+ T Cell Homeostasis

2006 • 64 citations

CD8 T cell memory development: CD4 T cell help is appreciated

2007 • 61 citations

Very Diverse CD8 T Cell Clonotypic Responses after Virus Infections

2004 • 61 citations

Establishment and recall of CD8⁺ T‐cell memory in a model of localized transient infection

2006 • 60 citations

TRAIL Deficiency Delays, but Does Not Prevent, Erosion in the Quality of “Helpless” Memory CD8 T Cells

2006 • 59 citations

Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors

2003 • 58 citations

Cutting Edge: Competition for APC by CTLs of Different Specificities Is Not Functionally Important During Induction of Antiviral Responses

2002 • 45 citations

Cutting Edge: Regulation of CD8+ T Cell Effector Population Size

2004 • 45 citations

Requirement for CD4 T Cell Help in Maintenance of Memory CD8 T Cell Responses Is Epitope Dependent

2007 • 38 citations

Aberrant Contraction of Antigen-Specific CD4 T Cells after Infection in the Absence of Gamma Interferon or Its Receptor

2006 • 36 citations

Antigen Presentation by Nonhemopoietic Cells Amplifies Clonal Expansion of Effector CD8 T Cells in a Pathogen-Specific Manner

2007 • 28 citations