Cytokine-Dependent Blimp-1 Expression in Activated T Cells Inhibits IL-2 Production

Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program

2002 • 1,000 citations

Blimp1 is a critical determinant of the germ cell lineage in mice

2005 • 999 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

2003 • 797 citations

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1994 • 752 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

Interleukin 2

1984 • 497 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells

2002 • 427 citations

Repression of c- myc Transcription by Blimp-1, an Inducer of Terminal B Cell Differentiation

1997 • 412 citations

Transcriptional repressor Blimp-1 regulates T cell homeostasis and function

2006 • 361 citations

The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse

2005 • 332 citations

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

2006 • 305 citations

Distinct Activation Signals Determine whether IL-21 Induces B Cell Costimulation, Growth Arrest, or Bim-Dependent Apoptosis

2004 • 250 citations

RORγt, a Novel Isoform of an Orphan Receptor, Negatively Regulates Fas Ligand Expression and IL-2 Production in T Cells

1998 • 235 citations

Suppression of Signal Transducer and Activator of Transcription 3–Dependent B Lymphocyte Terminal Differentiation by Bcl-6

2000 • 219 citations

BLIMP-1 mediates extinction of major histocompatibility class II transactivator expression in plasma cells

2000 • 213 citations

Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4

2000 • 206 citations

Role for Bcl-6 in the generation and maintenance of memory CD8[+] T cells

2002 • 192 citations

Molecular regulation of interleukin‐2 expression by CD28 co‐stimulation and anergy

1998 • 190 citations

STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression

2005 • 161 citations

IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production.

1990 • 155 citations

Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors

2000 • 153 citations

BLIMP-1: trigger for differentiation of myeloid lineage

2000 • 148 citations

IL-2 Regulates Perforin and Granzyme Gene Expression in CD8+ T Cells Independently of Its Effects on Survival and Proliferation

2005 • 138 citations

Interleukin 2 upregulates expression of its receptor on a T cell clone.

1985 • 102 citations

Repression of c-mycIs Necessary but Not Sufficient for Terminal Differentiation of B Lymphocytes In Vitro

2000 • 100 citations

Initial Antigen Encounter Programs CD8+ T Cells Competent to Develop into Memory Cells That Are Activated in an Antigen-Free, IL-7- and IL-15-Rich Environment

2004 • 99 citations

Transcriptional regulatory cascades controlling plasma cell differentiation

2003 • 95 citations

The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer

1999 • 93 citations

Differential Effect of B Lymphocyte–induced Maturation Protein (Blimp-1) Expression on Cell Fate during B Cell Development

1998 • 90 citations

Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells

2001 • 85 citations

Blimp1 and the Emergence of the Germ Line during Development in the Mouse

2005 • 84 citations

DNA array analysis of interleukin-2-regulated immediate/early genes.

2002 • 81 citations

A New Regulatory Region of the IL-2 Locus That Confers Position-Independent Transgene Expression

2001 • 73 citations

Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors

2003 • 58 citations

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes

2005 • 53 citations

Retroviral Delivery of Peptide Modulators of Cellular Functions

2000 • 48 citations

Very early and transient vegetal-plate expression of SpKrox1, a Krüppel/Krox gene from Strongylocentrotus purpuratus

1996 • 44 citations

Interleukin 2 Leads to Dose-Dependent Expression of the Alpha Chain of the IL-2 Receptor on CD25-Negative T Lymphocytes in the Absence of Exogenous Antigenic Stimulation

2000 • 44 citations

Transcriptional Program of Apoptosis Induction following Interleukin 2 Deprivation: Identification of RC3, a Calcium/Calmodulin Binding Protein, as a Novel Proapoptotic Factor

2003 • 37 citations

Inhibition of CTL induction by rapamycin: IL-2 rescues granzyme B and perforin expression but only partially restores cytotoxic activity.

1997 • 31 citations

Inducing P-Selectin Ligand Formation in CD8 T Cells: IL-2 and IL-12 Are Active In Vitro but Not Required In Vivo

2005 • 16 citations