A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

The Biology of Interleukin-2

2007 • 986 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

1999 • 712 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

2008 • 705 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

A Two-Step Process for Thymic Regulatory T Cell Development

2008 • 615 citations

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

2007 • 599 citations

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

2007 • 579 citations

Nonredundant roles for Stat5a/b in directly regulating Foxp3

2007 • 561 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

2008 • 405 citations

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

2007 • 367 citations

Distinct IL-2 Receptor Signaling Pattern in CD4+CD25+ Regulatory T Cells

2004 • 279 citations

Homeostasis of memory T cells

2006 • 275 citations

Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

2005 • 237 citations

Distinct Effects of STAT5 Activation on CD4+ and CD8+ T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells

2003 • 207 citations

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

2003 • 207 citations

SIGNALING DOMAINS OF THE INTERLEUKIN 2 RECEPTOR

2001 • 205 citations

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

1996 • 202 citations

Cytokine-Dependent Blimp-1 Expression in Activated T Cells Inhibits IL-2 Production

2007 • 178 citations

IL-2 Secretion by CD4+ T Cells In Vivo Is Rapid, Transient, and Influenced by TCR-Specific Competition

2004 • 166 citations

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

1997 • 158 citations

PTEN inhibits IL-2 receptor-mediated expansion of CD4+CD25+ Tregs

2006 • 157 citations

Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells

2007 • 156 citations

Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors

2000 • 153 citations

Loss of Tolerance and Autoimmunity Affecting Multiple Organs inSTAT5A/5B-Deficient Mice

2003 • 130 citations

The Proteasome Regulates Receptor-mediated Endocytosis of Interleukin-2

2001 • 116 citations

Bone marrow versus thymic pathways of natural killer cell development

2006 • 112 citations

Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells

2001 • 85 citations

Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma

2007 • 79 citations

Distinct Tyrosine Residues within the Interleukin-2 Receptor β Chain Drive Signal Transduction Specificity, Redundancy, and Diversity

1996 • 75 citations

Novel animal models for Sjögren's syndrome: Expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice

2006 • 63 citations

Functional dissection of the cytoplasmic subregions of the IL-2 receptor beta c chain in primary lymphocyte populations

1998 • 61 citations

STAT5 Is Essential for Akt/p70S6 Kinase Activity during IL-2-Induced Lymphocyte Proliferation

2007 • 58 citations

Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors

2003 • 58 citations

Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells

2006 • 56 citations

IL-2 and IL-15 Each Mediate De Novo Induction of FOXP3 Expression in Human Tumor Antigen-specific CD8 T Cells

2007 • 41 citations

Interleukin-2 (IL-2)-mediated Induction of the IL-2 Receptor α Chain Gene

1997 • 39 citations

Frontline: An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cellsin vivo

2004 • 33 citations

Spontaneous Expression of Interleukin-2In Vivoin Specific Tissues of Young Mice

1997 • 32 citations

Quantitative assessment concerning the contribution of IL-2R for superantigen-mediated T cell responses in vivo

2006 • 15 citations