Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

2007 • 1,712 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

2005 • 1,167 citations

The Biology of Interleukin-2

2007 • 986 citations

Effector and Memory CTL Differentiation

2006 • 908 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

2006 • 770 citations

CD8+ T Cell Effector Mechanisms in Resistance to Infection

2000 • 725 citations

REGULATION OF TH2 DIFFERENTIATION ANDIl4LOCUS ACCESSIBILITY

2006 • 625 citations

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

2008 • 616 citations

Signals required for programming effector and memory development by CD8⁺ T cells

2006 • 574 citations

Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

2007 • 567 citations

Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

2009 • 563 citations

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

2010 • 534 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells

2003 • 494 citations

Early Programming of T Cell Populations Responding to Bacterial Infection

2000 • 492 citations

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

2009 • 459 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

Linear Differentiation of Cytotoxic Effectors into Memory T Lymphocytes

1999 • 393 citations

Anomalous Type 17 Response to Viral Infection by CD8 ⁺ T Cells Lacking T-bet and Eomesodermin

2008 • 381 citations

Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation

2002 • 326 citations

Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

1998 • 323 citations

Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation

2006 • 323 citations

CD8+ T cell contraction is controlled by early inflammation

2004 • 322 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

Interleukin 2: from immunostimulation to immunoregulation and back again

2007 • 264 citations

Delivering the kiss of death: progress on understanding how perforin works

2007 • 250 citations

Memory CD4 T cells emerge from effector T-cell progenitors

2008 • 248 citations

Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response

2006 • 213 citations

Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN

2009 • 202 citations

The Roles of IL-12 in Providing a Third Signal for Clonal Expansion of Naive CD8 T Cells

2002 • 196 citations

Role for Bcl-6 in the generation and maintenance of memory CD8[+] T cells

2002 • 192 citations

Different T Cell Receptor Signals Determine CD8 ⁺ Memory Versus Effector Development

2009 • 188 citations

Differential role of IL‐2R signaling for CD8⁺ T cell responses in acute and chronic viral infections

2007 • 179 citations

Secondary Replicative Function of CD8 ⁺ T Cells That Had Developed an Effector Phenotype

2009 • 161 citations

Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8⁺T cells in influenza virus-infected mice

2003 • 150 citations

The CD8 Population in CD4-deficient Mice Is Heavily Contaminated with MHC Class II–restricted T Cells

2004 • 133 citations

Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses

2002 • 128 citations

Interleukin 2 Receptor Signaling Regulates the Perforin Gene through Signal Transducer and Activator of Transcription (Stat)5 Activation of Two Enhancers

1999 • 113 citations

Manipulating the Rate of Memory CD8+ T Cell Generation after Acute Infection

2007 • 110 citations

Initial Antigen Encounter Programs CD8+ T Cells Competent to Develop into Memory Cells That Are Activated in an Antigen-Free, IL-7- and IL-15-Rich Environment

2004 • 99 citations

CD8 single-cell gene coexpression reveals three different effector types present at distinct phases of the immune response

2007 • 91 citations

Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells

2001 • 85 citations

Chromosome Transfer Activates and Delineates a Locus Control Region for Perforin

2007 • 39 citations

A reliable method to display authentic DNase I hypersensitive sites at long-ranges in single-copy genes from large genomes

2006 • 23 citations

Enumeration of Cytotoxic CD8 T Cells Ex Vivo during the Response toListeria monocytogenesInfection

2008 • 13 citations