Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

IL-17 and Th17 Cells

2009 • 4,491 citations

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

2009 • 4,117 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

A microbial symbiosis factor prevents intestinal inflammatory disease

2008 • 2,187 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

2007 • 2,031 citations

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

2009 • 1,942 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

2007 • 1,809 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

2008 • 1,801 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

2008 • 1,695 citations

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

2009 • 1,688 citations

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

2008 • 1,653 citations

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

2008 • 1,624 citations

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

2009 • 1,545 citations

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

2008 • 1,544 citations

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

2008 • 1,524 citations

IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

2006 • 1,520 citations

Retinoic Acid Imprints Gut-Homing Specificity on T Cells

2004 • 1,460 citations

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

2009 • 1,447 citations

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

2007 • 1,446 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

2008 • 1,438 citations

Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin

2006 • 1,344 citations

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

2009 • 1,340 citations

Clostridium difficile infection: new developments in epidemiology and pathogenesis

2009 • 1,337 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

2008 • 1,250 citations

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

2008 • 1,228 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

2009 • 1,171 citations

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

2007 • 1,161 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

2009 • 1,079 citations

Enteric defensins are essential regulators of intestinal microbial ecology

2009 • 1,076 citations

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

2010 • 1,064 citations

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

2009 • 1,038 citations

ATP drives lamina propria TH17 cell differentiation

2008 • 1,035 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

The Biology of Interleukin-2

2007 • 986 citations

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 • 972 citations

IL-23 promotes tumour incidence and growth

2006 • 968 citations

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

2008 • 952 citations

The core gut microbiome, energy balance and obesity

2009 • 941 citations

CD4 ⁺ Regulatory T Cells Control T _H 17 Responses in a Stat3-Dependent Manner

2009 • 934 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

2009 • 898 citations

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

2007 • 887 citations

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 • 871 citations

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

2005 • 870 citations

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

2007 • 819 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

What are the consequences of the disappearing human microbiota?

2009 • 804 citations

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

2009 • 799 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

Understanding the IL-23–IL-17 immune pathway

2005 • 759 citations

Dendritic cells in intestinal immune regulation

2008 • 745 citations

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

2009 • 729 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

2007 • 704 citations

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

2007 • 695 citations

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

2008 • 689 citations

P<scp>hysiological</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponse and</scp>I<scp>nflammatory</scp>T<scp>issue</scp>D<scp>amage by</scp>H<scp>ypoxia</scp>-I<scp>nducible</scp>F<scp>actors and</scp>A<scp>denosine</scp>A_2AR<scp>eceptors</scp>

2004 • 672 citations

The development of inflammatory TH-17 cells requires interferon-regulatory factor 4

2007 • 665 citations

Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology

2006 • 664 citations

Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

2007 • 618 citations

A Two-Step Process for Thymic Regulatory T Cell Development

2008 • 615 citations

DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27

2007 • 608 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

2008 • 589 citations

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

2005 • 583 citations

The immune gene repertoire encoded in the purple sea urchin genome

2006 • 580 citations

IL-23 plays a key role inHelicobacter hepaticus–induced T cell–dependent colitis

2006 • 570 citations

The AP-1 transcription factor Batf controls TH17 differentiation

2009 • 568 citations

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

2007 • 567 citations

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

2009 • 563 citations

Preferential Generation of Follicular B Helper T Cells from Foxp3 ⁺ T Cells in Gut Peyer's Patches

2009 • 559 citations

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

2009 • 545 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

2006 • 502 citations

Heterogeneity of natural Foxp3 ⁺ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

2009 • 493 citations

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses

2008 • 487 citations

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

2007 • 485 citations

Activated CD4+CD25+ T cells selectively kill B lymphocytes

2006 • 484 citations

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

2008 • 474 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

2008 • 454 citations

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

2008 • 425 citations

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

2008 • 405 citations

IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice

2008 • 398 citations

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

2008 • 393 citations

Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis

2009 • 378 citations

Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor

2009 • 363 citations

Obesity predisposes to Th17 bias

2009 • 360 citations

Approaching the Asymptote: 20 Years Later

2009 • 359 citations

MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection

2007 • 353 citations

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

2010 • 333 citations

IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis

2007 • 333 citations

Dual nature of the adaptive immune system in lampreys

2009 • 316 citations

γδ T cells: an important source of IL-17

2008 • 314 citations

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

2009 • 305 citations

Interleukin-22-Producing Natural Killer Cells and Lymphoid Tissue Inducer-like Cells in Mucosal Immunity

2009 • 296 citations

Control of immune pathology by regulatory T cells

1998 • 289 citations

Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo

2005 • 250 citations

IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development

2008 • 250 citations

How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic Islets

2009 • 237 citations

Gene-environment interactions in asthma

2009 • 229 citations

Regulatory T Cells in Immunologic Self-Tolerance and Autoimmune Disease

2005 • 198 citations

Transcriptional regulatory networks in Th17 cell differentiation

2009 • 181 citations

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

2009 • 178 citations

Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice

2009 • 176 citations

The interleukin‐23 axis in intestinal inflammation

2008 • 169 citations

IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease

2008 • 165 citations

Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell–mediated effects on regulatory T cells

2008 • 160 citations

Induction of organ‐selective CD4⁺ regulatory T cell homing

2007 • 158 citations

Cutting Edge: TCR Stimulation Is Sufficient for Induction of Foxp3 Expression in the Absence of DNA Methyltransferase 1

2009 • 153 citations

Extracellular redox modulation by regulatory T cells

2009 • 139 citations

Rapid accumulation of an interleukin 17 homolog transcript in Crassostrea gigas hemocytes following bacterial exposure

2008 • 103 citations

Normal intestinal microbiota in the aetiopathogenesis of rheumatoid arthritis

2003 • 84 citations

Lack of Foxp3 function and expression in the thymic epithelium

2007 • 76 citations

Hygiene, microbial diversity and immune regulation

2007 • 34 citations

The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology

2005 • 27 citations