Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

Growth factors in the extracellular matrix

1997 • 879 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Specificity, diversity, and regulation in TGF‐β superfamily signaling

1999 • 644 citations

Receptors for the TGF-β family

1992 • 638 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily

1999 • 562 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

1991 • 509 citations

Transforming Growth Factor β1, in the Presence of Granulocyte/Macrophage Colony-stimulating Factor and Interleukin 4, Induces Differentiation of Human Peripheral Blood Monocytes into Dendritic Langerhans Cells

1998 • 507 citations

Hematopoietic regulators: redundancy or subtlety?

1993 • 473 citations

A murine model of hereditary hemorrhagic telangiectasia

1999 • 472 citations

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

1997 • 470 citations

Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction.

1980 • 461 citations

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

1994 • 450 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

1999 • 430 citations

Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro

1995 • 416 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

1987 • 407 citations

Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor

1993 • 401 citations

Human Mast Cell Chymase and Leukocyte Elastase Release Latent Transforming Growth Factor-β1 from the Extracellular Matrix of Cultured Human Epithelial and Endothelial Cells

1995 • 398 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.

1987 • 387 citations

Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells

1999 • 383 citations

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

1998 • 369 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.

1995 • 333 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Identification of another member of the transforming growth factor type beta gene family.

1988 • 326 citations

Smad5 and DPC4 Are Key Molecules in Mediating BMP-2-induced Osteoblastic Differentiation of the Pluripotent Mesenchymal Precursor Cell Line C2C12

1998 • 319 citations

TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors.

1996 • 312 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

TGF-β1 Prevents the Noncognate Maturation of Human Dendritic Langerhans Cells

1999 • 303 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells.

1993 • 290 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.

1995 • 273 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Role for carbohydrate structures inTGF-β1 latency

1989 • 270 citations

TGF‐β Latency: Biological Significance and Mechanisms of Activation

1997 • 261 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.

1991 • 243 citations

Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero.

1992 • 243 citations

Immune dysregulation in TGF-beta 1-deficient mice.

1994 • 231 citations

Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action.

1990 • 229 citations

Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro

1988 • 229 citations

Complementary Deoxyribonucleic Acid Cloning of a Messenger Ribonucleic Acid Encoding Transforming Growth Factor β 4 from Chicken Embryo Chondrocytes

1988 • 227 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta

1990 • 227 citations

Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines.

1988 • 222 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis

1999 • 212 citations

Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells

1996 • 204 citations

Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse

1996 • 203 citations

flt3 Ligand in Cooperation With Transforming Growth Factor-β1 Potentiates In Vitro Development of Langerhans-Type Dendritic Cells and Allows Single-Cell Dendritic Cell Cluster Formation Under Serum-Free Conditions

1997 • 203 citations

Differential proliferative effects of transforming growth factor-beta on human hematopoietic progenitor cells.

1988 • 195 citations

Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.

1994 • 192 citations

Release from quiescence of CD34+ CD38- human umbilical cord blood cells reveals their potentiality to engraft adults.

1993 • 189 citations

The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand.

1993 • 181 citations

SMAD3/4-dependent transcriptional activation of the human type VII collagen gene ( COL 7A1 ) promoter by transforming growth factor β

1998 • 178 citations

The high molecular weight receptor to transforming growth factor-beta contains glycosaminoglycan chains.

1988 • 178 citations

Biology of TGF-β in knockout and transgenic mouse models

1997 • 178 citations

Transforming Growth Factor β1 Inhibits Fas Ligand Expression and Subsequent Activation-induced Cell Death in T Cells via Downregulation of c-Myc

1999 • 177 citations

Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis.

1990 • 177 citations

Characterization of latent TGF-beta activation by murine peritoneal macrophages.

1995 • 174 citations

The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis

1990 • 172 citations

Transforming growth factor beta directly regulates primitive murine hematopoietic cell proliferation

1990 • 164 citations

CD34+ human marrow cells that express low levels of Kit protein are enriched for long-term marrow-engrafting cells

1996 • 160 citations

TGF-β singaling and cancer: structural and functional consequences of mutations in Smads

1998 • 160 citations

M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-β1

1999 • 159 citations

Transforming growth factor beta abrogates the effects of hematopoietins on eosinophils and induces their apoptosis.

1994 • 151 citations

Stem cell factor retards differentiation of normal human erythroid progenitor cells while stimulating proliferation

1995 • 149 citations

Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells: distinct and key interactions with the ligands for c-kit and flt3, and inhibitory effects of TGF-beta and TNF-alpha.

1997 • 149 citations

TGF-β1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation

2000 • 148 citations

Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-β1 gene

1998 • 147 citations

Isolation of a Novel Latent Transforming Growth Factor-β Binding Protein Gene (LTBP-3)

1995 • 147 citations

A Dominant Inhibitory Mutant of the Type II Transforming Growth Factor β Receptor in the Malignant Progression of a Cutaneous T-Cell Lymphoma

1996 • 146 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 145 citations

Transforming growth factor‐β and megakaryocytes in the pathogenesis of idiopathic myelofibrosis

1994 • 141 citations

Human burst-forming units-erythroid need direct interaction with stem cell factor for further development

1991 • 138 citations

Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition

1997 • 134 citations

Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia

1996 • 133 citations

Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.

1994 • 133 citations

Comparison of the Effects of Growth Factors on Retroviral Vector-Mediated Gene Transfer and the Proliferative Status of Human Hematopoietic Progenitor Cells

1990 • 133 citations

A Deletion in the Gene for Transforming Growth Factor β Type I Receptor Abolishes Growth Regulation by Transforming Growth Factor β in a Cutaneous T-Cell Lymphoma

1999 • 131 citations

Interacting cytokines regulate in vitro human megakaryocytopoiesis

1989 • 130 citations

Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin- primitive progenitor cells

1996 • 129 citations

Identification and Characterization of a New Latent Transforming Growth Factor-β-binding Protein, LTBP-4

1998 • 128 citations

A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice.

1997 • 125 citations

Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

1998 • 123 citations

Reduction in levels of the cyclin-dependent kinase inhibitor p27 ^kip-1 coupled with transforming growth factor β neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells

1998 • 119 citations

Monocyte adhesion in patients with bone marrow fibrosis is required for the production of fibrogenic cytokines. Potential role for interleukin-1 and TGF-beta.

1994 • 117 citations

TGF-beta 1 promotes in vitro generation of dendritic cells by protecting progenitor cells from apoptosis.

1997 • 115 citations

The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta.

1996 • 115 citations

TGF-beta down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors.

1997 • 111 citations

Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor.

1991 • 111 citations

Smad6 Suppresses TGF-β-Induced Growth Inhibition in COLO-357 Pancreatic Cancer Cells and Is Overexpressed in Pancreatic Cancer

1999 • 109 citations

Inhibition of early murine hemopoietic progenitor cell proliferation after in vivo locoregional administration of transforming growth factor-beta 1.

1989 • 107 citations

Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition

1996 • 107 citations

Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors

1994 • 107 citations

Synthesis of transforming growth factor-beta 1 by megakaryocytes and its localization to megakaryocyte and platelet alpha-granules

1990 • 106 citations

Regulation of Cell Surface Tissue Transglutaminase: Effects on Matrix Storage of Latent Transforming Growth Factor-β Binding Protein-1

1999 • 105 citations

Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow.

1995 • 102 citations

The t(3;21) Fusion Product, AML1/Evi-1, Interacts With Smad3 and Blocks Transforming Growth Factor-β–Mediated Growth Inhibition of Myeloid Cells

1998 • 102 citations

Transforming Growth Factor-β-Mediated Apoptosis in the Ramos B-Lymphoma Cell Line Is Accompanied by Caspase Activation and Bcl-XLDownregulation

1998 • 101 citations

Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia

1997 • 101 citations

Comparative effects of suppressive cytokines on isolated single CD34(3+) stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum.

1993 • 101 citations

Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding.

1997 • 100 citations

Bidirectional effects of transforming growth factor beta (TGF-beta) on colony-stimulating factor-induced human myelopoiesis in vitro: differential effects of distinct TGF-beta isoforms

1991 • 100 citations

CD34+ Cell-Derived CD14+ Precursor Cells Develop into Langerhans Cells in a TGF-β1-Dependent Manner

1999 • 100 citations

Transforming growth factor beta inhibits megakaryocyte growth and endomitosis

1992 • 99 citations

Dual implication of fibrogenic cytokines in the pathogenesis of fibrosis and myeloproliferation in myeloid metaplasia with myelofibrosis

1999 • 99 citations

Endoglin is expressed on a subpopulation of immature erythroid cells of normal human bone marrow.

1991 • 92 citations

Transforming Growth Factor-β1 Polarizes Murine Hematopoietic Progenitor Cells to Generate Langerhans Cell-Like Dendritic Cells Through a Monocyte/Macrophage Differentiation Pathway

1999 • 89 citations

Efficient Association of an Amino-terminally Extended Form of Human Latent Transforming Growth Factor-β Binding Protein with the Extracellular Matrix

1995 • 89 citations

Cutting Edge: Immature Dendritic Cells Generated from Monocytes in the Presence of TGF-β1 Express Functional C-C Chemokine Receptor 6

1999 • 89 citations

Transforming growth factor beta 1 is an inducer of erythroid differentiation.

1994 • 88 citations

TGF-β cooperates with TGF-α to induce the self–renewal of normal erythrocytic progenitors: evidence for an autocrine mechanism

1999 • 88 citations

Haemopoiesis in Long-Term Bone Marrow Cultures

1979 • 85 citations

The Smad5 Gene Is Involved in the Intracellular Signaling Pathways That Mediate the Inhibitory Effects of Transforming Growth Factor-β on Human Hematopoiesis

1998 • 84 citations

Somatic alterations of the SMAD-2 gene in human colorectal cancers

1998 • 84 citations

Effect of thrombopoietin on the development of megakaryocytes and platelets: an ultrastructural analysis

1996 • 83 citations

Transforming growth factor-beta enhances the M-CSF and GM-CSF-stimulated proliferation of macrophages.

1992 • 82 citations

Transforming growth factor-beta trans-modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines

1991 • 80 citations

Transforming Growth Factor Beta 1 is Significantly Elevated in Plasma of Patients Suffering from Renal Cell Carcinoma

1996 • 78 citations

Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: Its relationship to type β transforming growth factor (TGF‐β)

1988 • 78 citations

Purification and characterization of transforming growth factor-beta 2.3 and -beta 1.2 heterodimers from bovine bone.

1992 • 77 citations

Transforming growth factor beta 1 inhibits expression of the gene products for steel factor and its receptor (c-kit)

1995 • 74 citations

Identification and activation of latent transforming growth factor β

1991 • 72 citations

Transforming growth factor-beta potently inhibits the viability- promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells

1995 • 72 citations

Endoglin: a 180-kD endothelial cell and macrophage restricted differentiation molecule

1992 • 71 citations

Transforming Growth Factor-β1 (TGF-β1) Induces Thrombopoietin From Bone Marrow Stromal Cells, Which Stimulates the Expression of TGF-β Receptor on Megakaryocytes and, in Turn, Renders Them Susceptible to Suppression by TGF-β Itself With High Specificity

1999 • 71 citations

Acidic cellular environments: Activation of latent tgf‐β and sensitization of cellular responses to tgf‐β and egf

1989 • 69 citations

High Proliferative Potential-Quiescent cells: a working model to study primitive quiescent hematopoietic cells

1998 • 67 citations

Cell Density-dependent Apoptosis in HL-60 Cells, Which Is Mediated by an Unknown Soluble Factor, Is Inhibited By Transforming Growth Factor β1 and Overexpression of Bcl-2

1997 • 66 citations

Excessive production of transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production

1993 • 65 citations

Mitogenic properties of major extracellular proteins

1991 • 60 citations

Mutation analysis of the transforming growth factor-β type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-β

1997 • 59 citations

Transforming growth factor-beta 1 bifunctionally regulates murine macrophage proliferation

1992 • 59 citations

Differentiation Stage–Specific Regulation of Primitive Human Hematopoietic Progenitor Cycling by Exogenous and Endogenous Inhibitors in an In Vivo Model

1999 • 57 citations

Modulation of retinoblastoma gene in normal adult hematopoiesis: peak expression and functional role in advanced erythroid differentiation.

1995 • 55 citations

Expression and phosphorylation of the retinoblastoma protein during induced differentiation of murine erythroleukemia cells.

1992 • 54 citations

Role of caspases and possible involvement of retinoblastoma protein during TGFβ-mediated apoptosis of human B lymphocytes

1999 • 52 citations

p21cip1 mRNA is controlled by endogenous transforming growth factor-?1 in quiescent human hematopoietic stem/progenitor cells

2000 • 52 citations

Transforming growth factor beta (TGF-beta), a potent inhibitor of erythropoiesis: neutralizing TGF-beta antibodies show erythropoietin as a potent stimulator of murine burst-forming unit erythroid colony formation in the absence of a burst-promoting activity

1995 • 52 citations

Autocrine transforming growth factor β1 blocks colony formation and progenitor cell generation by hemopoietic stem cells stimulated with steel factor

1993 • 51 citations

TGF-β Knockout and Dominant-Negative Receptor Transgenic Mice

1998 • 51 citations

Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin.

1994 • 51 citations

Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit

1995 • 51 citations

Characterization of TGF‐β1‐binding proteins in human bone marrow stromal cells

1996 • 51 citations

Molecular Analysis of Primitive Hematopoietic Cell Proliferation Control Mechanisms^a

1991 • 51 citations

Serum‐free medium allows the optimal growth of human megakaryocyte progenitors compared with human plasma supplemented cultures: Role of TGF β

1993 • 50 citations

Accelerated cell-cycling of hematopoietic progenitors by the flt3 ligand that is modulated by transforming growth factor-beta

1996 • 49 citations

Transforming Growth Factor-β1 Abrogates Fas-Induced Growth Suppression and Apoptosis of Murine Bone Marrow Progenitor Cells

1997 • 47 citations

Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha

1996 • 46 citations

Betaglycan has multiple binding sites for transforming growth factor-β 1

1996 • 46 citations

TGF-beta is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Differential effects of TGF-beta 1 and TGF-beta 3.

1993 • 46 citations

The transcription factor Evi-1

1999 • 45 citations

Transforming growth factor‐beta 1 delays formation of granulocyte‐macrophage colony‐forming cells, but spares more primitive progenitors during ex vivo expansion of CD34⁺ haemopoietic progenitor cells

1997 • 44 citations

Heterogenous response of B lymphocytes to transforming growth factor‐beta in B‐cell chronic lymphocytic leukaemia: correlation with the expression of TGF‐β receptors

1997 • 43 citations

Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-β1 is a cell cycle–independent effect and influences their hematopoietic potential

2000 • 43 citations

Reduced responsiveness of bone marrow megakaryocyte progenitors to platelet‐derived transforming growth factor β1, produced in normal amount, in patients with essential thrombocythaemia

1993 • 42 citations

Transforming growth factor β inhibits the action of stem cell factor on mouse and human hematopoietic progenitors

1992 • 42 citations

Transforming growth factor-β receptors type I, II and III in phenobarbital-promoted rat liver tumors

1994 • 42 citations

Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit

1996 • 41 citations

Effect of transforming growth factor-beta 1 on proliferation and induction of hemoglobin accumulation in K-562 cells

1989 • 40 citations

Activin A‐induced diffrentiation in K562 cells is associated with a transient hypophosphorylation of RB protein and the concomitant block of cell cycle at G₁ phase

1992 • 39 citations

Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF‐β₁ by bone marrow stromal cells

1999 • 39 citations

TGF-β inhibits growth and induces apoptosis in leukemic B cell precursors

1997 • 37 citations

Deposition of Transforming Growth Factor-βin the Marrow in Myelofibrosis, and the Intracellular Localization and Secretion of TGF-βby Leukemic Cells

1995 • 36 citations

The TGF-β type II receptor in chronic myeloid leukemia: analysis of microsatellite regions and gene expression

1999 • 36 citations

Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells.

1995 • 34 citations

Chronic administration of transforming growth factor‐beta suppresses erythropoietin‐dependent erythropoiesis and induces tumour necrosis factor in vivo

1993 • 34 citations

Truncation of the TGF-β type II receptor gene results in insensitivity to TGF-β in human gastric cancer cells

1999 • 33 citations

Increased Stable Retroviral Gene Transfer in Early Hematopoietic Progenitors Released from Quiescence

1996 • 32 citations

The Liver in Transforming Growth Factor-Beta-1 (TGF-β1) Null Mutant Mice

1996 • 30 citations

TGF-β1 drives and accelerates erythroid differentiation in the Epo-dependent UT-7 cell line even in the absence of erythropoietin

2000 • 29 citations

Retinoblastoma gene deficiency has mitogenic but not tumorigenic effects on erythropoiesis.

1997 • 29 citations

Specific dose-response effects of TGF-β1 on developmentally distinct hematopoietic stem/progenitor cells from human umbilical cord blood

2000 • 29 citations

Transforming growth factor beta inhibits endomitosis in the Dami human megakaryocytic cell line

1990 • 28 citations

Retroviral-Mediated Gene Transduction of c-kit Into Single Hematopoietic Progenitor Cells From Cord Blood Enhances Erythroid Colony Formation and Decreases Sensitivity to Inhibition by Tumor Necrosis Factor- and Transforming Growth Factor-β1

1999 • 27 citations

Transforming growth factor β1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells

1997 • 23 citations

Structural basis for the pathophysiology of lipoprotein(a) in the athero-thrombotic process

1997 • 23 citations

Essential thrombocythemia: Impaired regulation of megakaryocyte progenitors

1991 • 22 citations

Study of the role of retinoblastoma protein in terminal differentiation of murine erythroleukemia cells.

1995 • 22 citations

Use of hematopoietic growth factors for in vitro expansion of precursor cell populations

1995 • 22 citations

Lack of transforming growth factor-β type II receptor expression in human retinoblastoma cells

1998 • 21 citations

Effects of transforming growth factor beta on megakaryocytic cell fusion and endomitosis

1992 • 18 citations

Pure Human Hematopoietic Progenitors: Direct Inhibitory Effect of Transforming Growth Factors‐β1 and ‐β2

1991 • 18 citations

Inhibition of erythroid differentiation by stem cell factor in K562 cells expressing the c-kit gene.

1994 • 17 citations

Abrogation of TGF-β activity during retroviral transduction improves murine hematopoietic progenitor and repopulating cell gene transfer efficiency

1998 • 17 citations

Effects of recombinant transforming growth factor-beta 1 on hematologic recovery after treatment of mice with 5-fluorouracil.

1991 • 17 citations

Bone marrow natural suppressor cells inhibit the growth of myeloid progenitor cells and the synthesis of colony-stimulating factors.

1992 • 16 citations

The Three Isoforms of Transforming Growth Factor‐β Co‐stimulate Rat T Cells and Inhibit Lymphocyte Apoptosis

1998 • 16 citations

Differential effects of transforming growth factor-?1 on distinct developmental stages of murine megakaryocytopoiesis

1994 • 16 citations

Developmentally regulated responsiveness to transforming growth factor-β is correlated with functional differences between human adult and fetal primitive hematopoietic progenitor cells

1999 • 15 citations

c-jun and c-fos are expressed by human megakaryocytes.

1992 • 15 citations

c-fos mRNA constitutive expression by mature human megakaryocytes.

1992 • 13 citations

Transforming growth factor β expression in human marrow stromal cells

1991 • 13 citations

Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia

1998 • 9 citations

EFFECT OF THE INTERACTION BETWEEN TRANSFORMING GROWTH FACTOR β AND ERYTHROPOIETIN ON THE PROLIFERATION OF NORMAL ERYTHROID PROGENITORS AND LEUKEMIC UT-7 CELLS: ACTION OF TRANSFORMING GROWTH FACTOR β ON THE ERYTHROPOIETIN RECEPTOR

1996 • 6 citations