Study of the role of retinoblastoma protein in terminal differentiation of murine erythroleukemia cells.

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1994 • 625 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

1991 • 343 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 326 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Specific enzymatic dephosphorylation of the retinoblastoma protein.

1993 • 258 citations

Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2

1992 • 255 citations

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.

1989 • 248 citations

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

1990 • 204 citations

Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.

1993 • 158 citations

Transient inhibition of initiation of S-phase associated with dimethyl sulfoxide induction of murine erythroleukemia cells to erythroid differentiation.

1977 • 124 citations

Erythrocytic maturation in vitro of murine (Friend) virus-induced leukemic cells.

1966 • 115 citations

Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation.

1987 • 101 citations

Specific Enzymatic Dephosphorylation of the Retinoblastoma Protein

1993 • 96 citations

Inducing differentiation of transformed cells with hybrid polar compounds: a cell cycle-dependent process.

1994 • 90 citations

Phase I clinical and pharmacokinetic study of hexamethylene bisacetamide (NSC 95580) administered as a five-day continuous infusion.

1987 • 77 citations

Murine erythroleukemia cell differentiation: relationship of globin gene expression and of prolongation of G1 to inducer effects during G1/early S.

1979 • 64 citations

Expression and phosphorylation of the retinoblastoma protein during induced differentiation of murine erythroleukemia cells.

1992 • 54 citations

Hexamethylenebisacetamide-induced erythroleukemia cell differentiation involves modulation of events required for cell cycle progression through G1.

1993 • 51 citations

Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cells.

1994 • 41 citations

Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells.

1994 • 33 citations