Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

1993 • 707 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.

1988 • 571 citations

An early pre-liver intraembryonic source of CFU-S in the developing mouse

1993 • 525 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Studies on the origin of blood vessels and of red corpuscles as seen in the living blastoderm of the chick during the second day of incubation

1920 • 457 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

1987 • 407 citations

Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors

1993 • 392 citations

Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action

1988 • 347 citations

Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms

1990 • 342 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

A molecular analysis of mouse development from 8 to 10 dayspost coitumdetects changes only in embryonic globin expression

1987 • 298 citations

Isolation and characterization of human bone marrow microvascular endothelial cells: hematopoietic progenitor cell adhesion

1994 • 287 citations

Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2

1989 • 280 citations

TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis

1990 • 239 citations

Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro

1988 • 229 citations

Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines.

1988 • 222 citations

Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting

1994 • 219 citations

Differential proliferative effects of transforming growth factor-beta on human hematopoietic progenitor cells.

1988 • 195 citations

Transforming growth factor beta₁ modulates extracellular matrix organization and cell‐cell junctional complex formation during in vitro angiogenesis

1990 • 184 citations

RNA and protein localisations of TGFβ2 in the early mouse embryo suggest an involvement in cardiac development

1993 • 166 citations

A fibronectin matrix is required for differentiation of murine erythroleukemia cells into reticulocytes.

1987 • 165 citations

[45] Production of transgenic mice

1993 • 161 citations

The DVR gene family in embryonic development

1991 • 159 citations

Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins.

1993 • 157 citations

Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo

1993 • 145 citations

Expression of TGF-β isoforms during first trimester human embryogenesis

1990 • 139 citations

Erythropoiesis in the Chick Embryo: The Role of Endoderm

1965 • 138 citations

Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

1991 • 137 citations

The effects of erythropoietin on haem synthesis in mouse yolk sac and cultured foetal liver cells

1966 • 130 citations

Mammalian development: A practical approach

1988 • 127 citations

Transforming growth factor β and basic fibroblast growth factor synergistically promote early bovine embryo development during the fourth cell cycle

1992 • 124 citations

Effects of retinoid deficiency on the development of the heart and vascular system of the quail embryo

1986 • 120 citations

Tissue interaction and the formation of the first erythroblasts of the chick embryo

1969 • 118 citations

Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor.

1991 • 111 citations

Differential modulation of vascular cell integrin and extracellular matrix expression in vitro by TGF‐β1 correlates with reciprocal effects on cell migration⁺

1992 • 93 citations

Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth

1994 • 91 citations

The DVR gene family in embryonic development

1991 • 84 citations

Localization and binding of transforming growth factor-β isoforms in mouse preimplantation embryos and in delayed and activated blastocysts

1992 • 81 citations

Development of the Fetal Mouse Palate in Suspension Organ Culture

1990 • 80 citations

Dissection and culture of postimplantation Embryos

1990 • 68 citations

Modulation of vascular cell behavior by transforming growth factors β

1992 • 61 citations

Coordinate regulation of Steel factor, its receptor (Kit), and cytoadhesion molecule (ICAM-1 and ELAM-1) mRNA expression in human vascular endothelial cells of differing origins.

1994 • 54 citations

Identification of a structural domain that distinguishes the actions of the type 1 and 2 isoforms of transforming growth factor beta on endothelial cells.

1992 • 48 citations

Effect of transforming growth factor-beta 1 on proliferation and induction of hemoglobin accumulation in K-562 cells

1989 • 40 citations

Growth factors and signal transduction in development

1995 • 29 citations

Transforming growth factor‐β1 enhances the suppression of human hematopoiesis by tumor necrosis factor‐α or recombinant interferon‐α

1989 • 23 citations