Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Transforming growth factor beta

2011 • 1,990 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Blood Vessel Formation: What Is Its Molecular Basis?

1996 • 1,242 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Hereditary Hemorrhagic Telangiectasia

1995 • 1,052 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Transforming growth factor βs and wound healing

1997 • 623 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

1995 • 551 citations

The TGF-β family and its composite receptors

1994 • 539 citations

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

1995 • 510 citations

Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

1992 • 495 citations

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

1984 • 477 citations

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1998 • 472 citations

Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.

1990 • 450 citations

Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor

1993 • 401 citations

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

1994 • 379 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells

1994 • 368 citations

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

1993 • 354 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

Activation of Signalling by the Activin Receptor Complex

1996 • 317 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

Bone morphogenetic proteins: An unconventional approach to isolation of first mammalian morphogens

1997 • 302 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

1995 • 275 citations

Determination of Type I Receptor Specificity by the Type II Receptors for TGF-β or Activin

1993 • 261 citations

Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line.

1988 • 256 citations

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor

1994 • 254 citations

Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors

1995 • 238 citations

Activin Is a Local Regulator of Human Cytotrophoblast Cell Differentiation¹

1997 • 225 citations

Regulated expression on human macrophages of endoglin, an Arg‐Gly‐Asp‐containing surface antigen

1992 • 222 citations

A T3-like protein complex associated with the antigen receptor on murine T cells

1986 • 213 citations

Identification and expression of two forms of the human transforming growth factor‐β‐binding protein endoglin with distinct cytoplasmic regions

1993 • 212 citations

Endoglin Regulates Trophoblast Differentiation along the Invasive Pathway in Human Placental Villous Explants*

1997 • 199 citations

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.

1994 • 193 citations

Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts

1992 • 186 citations

Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2.

1997 • 160 citations

TGF-β: A Critical Modulator of Immune Cell Function

1997 • 160 citations

Signal transduction by members of the transforming growth factor-β superfamily

1996 • 160 citations

Inhibition of vascular endothelial cell growth by activin-A.

1993 • 157 citations

Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative.

1997 • 154 citations

Heterodimeric transforming growth factor beta. Biological properties and interaction with three types of cell surface receptors.

1988 • 138 citations

[17] Identification of receptor for type-β transforming growth factor

1987 • 134 citations

Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.

1994 • 133 citations

Signalling by TGF-β family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin

1996 • 132 citations

Localization of Endoglin, a Transforming Growth Factor-β Binding Protein, and of CD44 and Integrins in Placenta during the First Trimester of Pregnancy1

1994 • 121 citations

Growth/Differentiation Factor-5 Induces Angiogenesisin Vivo

1997 • 103 citations

Endoglin is expressed on a subpopulation of immature erythroid cells of normal human bone marrow.

1991 • 92 citations

Distribution and Characterization of Specific Cellular Binding Proteins for Bone Morphogenetic Protein-2

1995 • 89 citations

Molecular cloning and characterization of the human and porcine transforming growth factor-β type III receptors

1992 • 85 citations

TGF-beta receptors and signal transduction.

1997 • 76 citations

Phosphorylation of the human-transforming-growth-factor-β-binding protein endoglin

1994 • 71 citations

Endoglin is a component of the transforming growth factor (TGF)-beta receptor complex of human pre-B leukemic cells.

1996 • 63 citations

Mapping epitopes to distinct regions of the extracellular domain of endoglin using bacterially expressed recombinant fragments

1997 • 63 citations

Distribution of endoglin in early human development reveals high levels on endocardial cushion tissue mesenchyme during valve formation

1998 • 62 citations

Molecular Defects in Rare Bleeding Disorders: Hereditary Haemorrhagic Telangiectasia

1997 • 61 citations

The GS Domain of the Transforming Growth Factor-β Type-I Receptor Is Important in Signal Transduction

1995 • 53 citations

Characterization of TGF‐β1‐binding proteins in human bone marrow stromal cells

1996 • 51 citations