Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer

1996 • 451 citations

Mad-related genes in the human

1996 • 308 citations

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1996 • 259 citations

The DCC Gene: Structural Analysis and Mutations in Colorectal Carcinomas

1994 • 224 citations

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas

1997 • 126 citations

Loss of expression of the DCC gene during progression of colorectal carcinomas in familial adenomatous polyposis and non-familial adenomatous polyposis patients.

1992 • 87 citations

Familial polyposis: recent advances

1995 • 63 citations