Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.

1991 • 243 citations

Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action.

1990 • 229 citations

Differential proliferative effects of transforming growth factor-beta on human hematopoietic progenitor cells.

1988 • 195 citations

Release from quiescence of CD34+ CD38- human umbilical cord blood cells reveals their potentiality to engraft adults.

1993 • 189 citations

Isolation of c-kit receptor-expressing cells from bone marrow, peripheral blood, and fetal liver: functional properties and composite antigenic profile

1991 • 188 citations

Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro: effects of combination with colony-stimulating factors.

1991 • 180 citations

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

1992 • 167 citations

Mast cell growth factor (c-kit ligand) supports the growth of human multipotential progenitor cells with a high replating potential

1991 • 144 citations

Role of the KIT protooncogene in normal and malignant human hematopoiesis.

1992 • 138 citations

Human primitive hematopoietic progenitor cells are more enriched in KITlow cells than in KIThigh cells

1993 • 138 citations

Stage-specific expression of c-kit protein by murine hematopoietic progenitors

1993 • 121 citations

Further phenotypic characterization and isolation of human hematopoietic progenitor cells using a monoclonal antibody to the c-kit receptor

1992 • 113 citations

Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors

1994 • 107 citations

The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hemopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic leukemic cells.

1991 • 98 citations

Transforming growth factor-beta trans-modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines

1991 • 80 citations

Transforming growth factor‐β: A bidirectional regulator of hematopoietic cell growth

1992 • 66 citations

TGF-beta is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Differential effects of TGF-beta 1 and TGF-beta 3.

1993 • 46 citations

Transforming growth factor-beta 1 interferes with the proliferation-inducing activity of stem cell factor in myelogenous leukemia blasts through functional down-regulation of the c-kit proto-oncogene product.

1993 • 41 citations

Sequential analysis of hematopoietic reconstitution achieved by transplantation of hematopoietic stem cells

1993 • 35 citations

Additive effects of steel factor and antisense TGF-beta 1 oligodeoxynucleotide on CD34+ hematopoietic progenitor cells.

1994 • 24 citations

CSF‐1 control of C‐FMS expression in normal human bone marrow progenitors

1993 • 17 citations

Co-stimulatory effects of steel factor, the c-kit ligand, on purified human hematopoietic progenitors in low cell density culture.

1993 • 4 citations