Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.

1996 • 445 citations

Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.

1995 • 333 citations

Cholinesterase as a Possible Marker for Early Cells of the Megakaryocytic Series

1973 • 297 citations

Megakaryocytic Differentiation Induced by Constitutive Activation of Mitogen-Activated Protein Kinase Kinase

1997 • 237 citations

The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl

1995 • 235 citations

Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases

1997 • 202 citations

Thrombopoietin Signal Transduction in Purified Murine Megakaryocytes

1997 • 199 citations

Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets

1996 • 189 citations

Endomitosis of Human Megakaryocytes Are Due to Abortive Mitosis

1998 • 178 citations

Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain

1997 • 158 citations

Control of Thrombopoietin-Induced Megakaryocytic Differentiation by the Mitogen-Activated Protein Kinase Pathway

1997 • 152 citations

Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets

1995 • 148 citations

The beta-PDGF receptor induces neuronal differentiation of PC12 cells.

1992 • 145 citations

Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro

1995 • 145 citations

A Role for Cyclin D3 in the Endomitotic Cell Cycle

1997 • 121 citations

Cyclin D3 is essential for megakaryocytopoiesis

1995 • 120 citations

The Cell Cycle in Polyploid Megakaryocytes Is Associated with Reduced Activity of Cyclin B1-dependent Cdc2 Kinase

1996 • 113 citations

Novel alterations in CDK1/cyclin B1 kinase complex formation occur during the acquisition of a polyploid DNA content.

1996 • 99 citations

Functional Regions of the Mouse Thrombopoietin Receptor Cytoplasmic Domain: Evidence for a Critical Region Which Is Involved in Differentiation and Can Be Complemented by Erythropoietin

1996 • 93 citations

Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation.

1996 • 90 citations

Activation of the Mitogen-Activated Protein Kinase Pathway Is Involved in and Sufficient for Megakaryocytic Differentiation of CMK Cells

1997 • 80 citations

Thrombopoietin induces activation of at least two distinct signaling pathways

1995 • 71 citations

Thrombopoietin Induces Tyrosine Phosphorylation and Activation of Mitogen-Activated Protein Kinases in a Human Thrombopoietin-Dependent Cell Line

1995 • 59 citations

Overexpression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest

1995 • 53 citations

Quantitative analysis of thrombopoietin receptors on human megakaryocytes

1998 • 24 citations

Megakaryocyte Biology

1997 • 11 citations