Acidic cellular environments: Activation of latent tgf‐β and sensitization of cellular responses to tgf‐β and egf

Growth Factors and Cancer

1991 • 2,044 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

The TGF-β family of growth and differentiation factors

1987 • 675 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.

1986 • 533 citations

Transforming growth factor production by chemically transformed cells.

1981 • 506 citations

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

1984 • 477 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

GROWTH FACTORS AND CANCER

1985 • 352 citations

Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines.

1985 • 344 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Serum contains a platelet-derived transforming growth factor.

1982 • 330 citations

β-Transforming Growth Factor is stored in human blood platelets as a latent high molecular weight complex

1986 • 241 citations

Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation

1984 • 238 citations

pH as a Determinant of Cellular Growth and Contact Inhibition

1971 • 236 citations

Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model.

1987 • 222 citations

Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets.

1984 • 212 citations

pH STUDIES IN HUMAN MALIGNANT TUMOURS

1966 • 157 citations

pH AND POPULATION DENSITY IN THE REGULATION OF ANIMAL CELL MULTIPLICATION

1971 • 136 citations

Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues.

1982 • 120 citations

Latent beta-transforming growth factor in nontransformed and Kirsten sarcoma virus-transformed normal rat kidney cells, clone 49F.

1984 • 112 citations

Continuous Noninvasive Monitoring of pH and Temperature in Rat Walker 256 Carcinoma During Normoglycemia and Hyperglycemia23

1984 • 94 citations

The <italic>p</italic>H of Rat Tumors Measured <italic>In Vivo</italic>

1955 • 92 citations

Cell cycle regulation by environmental pH

1984 • 67 citations

pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes.

1982 • 66 citations

Exposure of cells to an acidic environment reverses the inhibiton by methylamine of the mitogenic response to epidermal growth factor

1982 • 26 citations

Bifunctional activity of transforming growth factor type β on the growth of NRK‐49F cells, normal and transformed by kirsten murine sarcoma virus

1988 • 10 citations

Chemically and virally transformed cells able to grow without anchorage in serum‐free medium: Evidence for an autocrine growth factor

1987 • 9 citations