A Deletion in the Gene for Transforming Growth Factor β Type I Receptor Abolishes Growth Regulation by Transforming Growth Factor β in a Cutaneous T-Cell Lymphoma

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor

1993 • 401 citations

Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

1997 • 383 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor

1989 • 325 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

Mad-related genes in the human

1996 • 308 citations

Molecules in focus Transforming growth factor-beta (TGF-β)

1998 • 306 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

TGF-β receptors and actions

1994 • 291 citations

Frequency of Smad gene mutations in human cancers.

1997 • 289 citations

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene

1998 • 288 citations

Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.

1998 • 284 citations

Regulation of differentiation by TFG-β

1996 • 223 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

Disruption of Transforming Growth Factor β Signaling by a Mutation That Prevents Transphosphorylation within the Receptor Complex

1995 • 217 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

The types II and III transforming growth factor-beta receptors form homo-oligomers.

1994 • 199 citations

Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells.

1996 • 195 citations

Biology of TGF-β in knockout and transgenic mouse models

1997 • 178 citations

Receptors for the TGF-β superfamily: multiple polypeptides and serine/threonine kinases

1993 • 164 citations

The clinicopathologic spectrum of lymphomatoid papulosis: Study of 31 cases

1983 • 162 citations

Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer.

1998 • 154 citations

Cyclin-Dependent Kinase Regulation during G1 Phase and Cell Cycle Regulation by TGF-ß

1997 • 147 citations

A Dominant Inhibitory Mutant of the Type II Transforming Growth Factor β Receptor in the Malignant Progression of a Cutaneous T-Cell Lymphoma

1996 • 146 citations

The Same Dominant T Cell Clone Is Present in Multiple Regressing Skin Lesions and Associated T Cell Lymphomas of Patients with Lymphomatoid Papulosis

1996 • 132 citations

Reduced Expression of Transforming Growth Factor β Type I Receptor Contributes to the Malignancy of Human Colon Carcinoma Cells

1996 • 122 citations

Loss of expression of transforming growth factor-beta receptors is associated with poor prognosis in prostate cancer patients.

1998 • 113 citations

Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition

1996 • 107 citations

Transforming growth factor-β and the immune system

1991 • 103 citations

Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia

1997 • 101 citations

Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract.

1998 • 98 citations

Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers

1998 • 82 citations

Transforming growth factor-beta and cancer: a love-hate relationship?

1997 • 76 citations

Transfection of the type I TGF-β receptor restores TGF-β responsiveness in pancreatic cancer

1998 • 69 citations

Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients.

1995 • 65 citations

Genetic instability in the 9q22.3 region is a late event in the development of squamous cell carcinoma

1998 • 51 citations

TGF-β: receptors and cell cycle arrest

1996 • 46 citations

Transforming growth factors beta slow down cell‐cycle progression in a murine interleukin‐2 dependent T‐cell line

1989 • 45 citations

Transforming Growth Factor-β, TGF-β

1996 • 41 citations

Cloning and Genomic Organization of the Human Transforming Growth Factor-β Type I Receptor Gene

1997 • 34 citations

Transforming growth factor beta 1 (TGF‐β1) receptor expression on resting and mitogen‐activated T cells

1989 • 23 citations

Lack of transforming growth factor-β type II receptor expression in human retinoblastoma cells

1998 • 21 citations

Transforming growth factor-beta (TGF-beta)-resistant helper T lymphocyte clones show a concomitant loss of all three types of TGF-beta receptors.

1991 • 20 citations