TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling
Data up to Jan 2025
Total Citations Per Year
Abstract
References (42)
Molecular Cloning: A Laboratory Manual
2001 • 133,517 citations
Molecular cloning: A laboratory manual
1990 • 85,659 citations
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
1996 • 2,320 citations
Mechanism of activation of the TGF-β receptor
1994 • 2,298 citations
[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
1991 • 1,463 citations
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling
1997 • 1,328 citations
[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations
1991 • 1,036 citations
Current Protocols in Molecular Biology
1989 • 1,007 citations
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
1996 • 899 citations
Receptor-associated Mad homologues synergize as effectors of the TGF-β response
1996 • 874 citations
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma
1996 • 855 citations
TGFβ Signaling: Receptors, Transducers, and Mad Proteins
1996 • 840 citations
MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling
1996 • 740 citations
MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways
1996 • 710 citations
A transcriptional partner for MAD proteins in TGF-β signalling
1996 • 699 citations
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.
1995 • 682 citations
A human Mad protein acting as a BMP-regulated transcriptional activator
1996 • 674 citations
Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.
1995 • 672 citations
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
1997 • 569 citations
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.
1996 • 528 citations
Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily
1996 • 432 citations
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
1997 • 365 citations
Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.
1987 • 357 citations
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.
1996 • 351 citations
Structural Framework for the Protein Kinase Family
1992 • 333 citations
Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.
1994 • 324 citations
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function
1997 • 317 citations
Activation of Signalling by the Activin Receptor Complex
1996 • 317 citations
Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.
1995 • 306 citations
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
1996 • 223 citations
Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4
1997 • 207 citations
Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.
1996 • 197 citations
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor
1996 • 172 citations
Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway
1997 • 168 citations
Intracellular signalling: The Mad way to do it
1996 • 162 citations
Signal transduction by members of the transforming growth factor-β superfamily
1996 • 160 citations
Characterization of Functional Domains within Smad4/DPC4
1997 • 151 citations
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.
1996 • 146 citations
Homomeric interactions between type II transforming growth factor-beta receptors.
1994 • 137 citations
[48] cDNA cloning and properties of glycogen synthase kinase-3
1991 • 131 citations
MAD-related proteins in TGF-β signalling
1996 • 92 citations
Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-β Signal Transduction by Human
1996 • 89 citations
Cited By (0)
No citing papers found in database