A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid

1961 • 3,860 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor

1985 • 1,119 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

1994 • 749 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

Expression of the β6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling

1995 • 470 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

1993 • 402 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

1996 • 312 citations

Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.

1992 • 292 citations

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells.

1993 • 290 citations

Requirement for Activin a and Transforming Growth Factor--β1 Pro-Regions in Homodimer Assembly

1990 • 266 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.

1994 • 250 citations

Multiple integrins mediate cell attachment to cytotactin/tenascin.

1993 • 248 citations

Redox-mediated activation of latent transforming growth factor-beta 1

1996 • 245 citations

Interactions between Growth Factors and Integrins: Latent Forms of Transforming Growth Factor-β Are Ligands for the Integrin αvβ1

1998 • 229 citations

Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils.

1996 • 222 citations

Release and activation of platelet latent TGF–β in blood clots during dissolution with plasmin

1995 • 216 citations

Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion

1998 • 209 citations

The integrin αvβ6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin

1998 • 153 citations

Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells.

1992 • 116 citations

Differential regulation of airway epithelial integrins by growth factors.

1996 • 97 citations

Structural characterization of the latent complex between transforming growth factor β1 and β1-latency-associated peptide

1996 • 76 citations

Expression of the Human Integrin β 6 Subunit in Alveolar Type II Cells and Bronchiolar Epithelial Cells Reverses Lung Inflammation in β 6 Knockout Mice

1998 • 76 citations

Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue.

1995 • 66 citations

Effects of β Subunit Cytoplasmic Domain Deletions on the Recruitment of the Integrin αvβ6 to Focal Contacts

1994 • 26 citations