TGF-β1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Bone Marrow as a Potential Source of Hepatic Oval Cells

1999 • 2,439 citations

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

1984 • 1,193 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

CD34: structure, biology, and clinical utility [see comments]

1996 • 891 citations

A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS

1964 • 889 citations

CD34: structure, biology, and clinical utility [see comments]

1996 • 690 citations

Antigen CD34+ marrow cells engraft lethally irradiated baboons.

1988 • 608 citations

Engraftment after infusion of CD34+ marrow cells in patients with breast cancer or neuroblastoma

1991 • 538 citations

The Effect of Differing Demands for Blood Cell Production on DNA Synthesis by Hemopoietic Colony-Forming Cells of Mice

1965 • 515 citations

Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell?

1979 • 513 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Granuloerythropoietic colonies in human bone marrow, peripheral blood, and cord blood

1978 • 411 citations

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

1987 • 407 citations

Identification of megakaryocytes, macrophages, and eosinophils in colonies of human bone marrow containing neurtophilic granulocytes and erythroblasts

1979 • 392 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.

1991 • 243 citations

Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro

1988 • 229 citations

Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development

1991 • 228 citations

Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines.

1988 • 222 citations

Adhesion Receptors as Regulators of the Hematopoietic Process

1998 • 208 citations

Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells

1996 • 204 citations

Differential proliferative effects of transforming growth factor-beta on human hematopoietic progenitor cells.

1988 • 195 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 195 citations

Transforming growth factor beta directly regulates primitive murine hematopoietic cell proliferation

1990 • 164 citations

CD34+ human marrow cells that express low levels of Kit protein are enriched for long-term marrow-engrafting cells

1996 • 160 citations

Proteolytic control of growth factor availability

1999 • 157 citations

Proliferative kinetics and differentiation of murine blast cell colonies in culture: Evidence for variable G₀ periods and constant doubling rates of early pluripotent hemopoietic progenitors

1983 • 145 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 145 citations

Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia

1996 • 133 citations

The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta.

1996 • 115 citations

Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype.

1995 • 105 citations

Pretreatment with transforming growth factor beta-3 protects small intestinal stem cells against radiation damage in vivo

1997 • 102 citations

Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia

1997 • 101 citations

Bidirectional effects of transforming growth factor beta (TGF-beta) on colony-stimulating factor-induced human myelopoiesis in vitro: differential effects of distinct TGF-beta isoforms

1991 • 100 citations

Transforming Growth Factor Beta 1 is Significantly Elevated in Plasma of Patients Suffering from Renal Cell Carcinoma

1996 • 78 citations

High Proliferative Potential-Quiescent cells: a working model to study primitive quiescent hematopoietic cells

1998 • 67 citations

Transforming growth factor‐β: A bidirectional regulator of hematopoietic cell growth

1992 • 66 citations

Interleukin-3 and interleukin-1 alpha allow earlier bone marrow progenitors to respond to human colony-stimulating factor 1

1988 • 58 citations

Effects of transforming growth factor beta 1 on growth and apoptosis of human acute myelogenous leukemia cells.

1993 • 56 citations

Autocrine transforming growth factor β1 blocks colony formation and progenitor cell generation by hemopoietic stem cells stimulated with steel factor

1993 • 51 citations

Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin.

1994 • 51 citations

Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit

1995 • 51 citations

Transforming growth factor beta 1 functions in monocytic differentiation of hematopoietic cells through autocrine and paracrine mechanisms.

1996 • 48 citations

Transforming Growth Factor-β1 Abrogates Fas-Induced Growth Suppression and Apoptosis of Murine Bone Marrow Progenitor Cells

1997 • 47 citations

Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha

1996 • 46 citations

Transforming growth factor‐beta 1 delays formation of granulocyte‐macrophage colony‐forming cells, but spares more primitive progenitors during ex vivo expansion of CD34⁺ haemopoietic progenitor cells

1997 • 44 citations

The growth response of Lin-Thy-1+ hematopoietic progenitors to cytokines is determined by the balance between synergy of multiple stimulators and negative cooperation of multiple inhibitors.

1994 • 40 citations

Interleukin-3 and interleukin-1 alpha allow earlier bone marrow progenitors to respond to human colony-stimulating factor 1

1988 • 40 citations

Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells.

1995 • 34 citations

Novel delivery system for inducing quiescence in intestinal stem cells in rats by transforming growth factor β1

1994 • 28 citations

Additive effects of steel factor and antisense TGF-beta 1 oligodeoxynucleotide on CD34+ hematopoietic progenitor cells.

1994 • 24 citations

Increased granulopoiesis after sequential administration of transforming growth factor-beta 1 and granulocyte-macrophage colony-stimulating factor.

1993 • 20 citations

TGF-beta 3 protects normal human hematopoietic progenitor cells treated with 4-hydroperoxycyclophosphamide in vitro.

1992 • 18 citations

Pure Human Hematopoietic Progenitors: Direct Inhibitory Effect of Transforming Growth Factors‐β1 and ‐β2

1991 • 18 citations

The suppressive effects of type beta transforming growth factor (TGF beta) on primitive murine hemopoietic progenitors are abrogated by interleukin-6 and granulocyte colony-stimulating factor.

1989 • 14 citations

Collection of placental blood with a view to hemopoietic reconstitution.

1990 • 13 citations