Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor beta

2011 • 1,990 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

1991 • 509 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

1990 • 407 citations

Thrombospondins: structure and regulation of expression

1992 • 345 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

Transforming Growth Factor β

1988 • 295 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Thrombospondin modulates focal adhesions in endothelial cells.

1989 • 271 citations

Role for carbohydrate structures inTGF-β1 latency

1989 • 270 citations

Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin.

1986 • 259 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

5462925 Transforming growth factor beta2,3

1996 • 255 citations

β-Transforming Growth Factor is stored in human blood platelets as a latent high molecular weight complex

1986 • 241 citations

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.

1993 • 241 citations

Type 1 Transforming Growth Factor Beta: Amplified Expression and Secretion of Mature and Precursor Polypeptides in Chinese Hamster Ovary Cells

1987 • 224 citations

Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.

1988 • 211 citations

Physiology of Thrombospondin

1990 • 195 citations

The pro domain of pre-pro-transforming growth factor .beta.1 when independently expressed is a functional binding protein for the mature growth factor

1990 • 185 citations

Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes.

1992 • 181 citations

Thrombospondins

1991 • 169 citations

Specific inhibition of endothelial cell proliferation by thrombospondin

1990 • 168 citations

Heparin-binding peptides from thrombospondins 1 and 2 contain focal adhesion-labilizing activity.

1993 • 157 citations

Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin‐binding domain and synthetic peptides from the type I repeats of thrombospondin

1993 • 155 citations

Transforming growth factors and control of neoplastic cell growth

1987 • 141 citations

The integrity of the conserved ‘WS motif’ common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction.

1991 • 130 citations

Interactions of recombinant and platelet transforming growth factor-β1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor

1989 • 127 citations

The functions of thrombospondin and its involvement in physiology and pathophysiology

1993 • 118 citations

The mechanism for the activation of latent TGF-beta during co-culture of endothelial cells and smooth muscle cells: cell-type specific targeting of latent TGF-beta to smooth muscle cells.

1993 • 114 citations

Acidic cellular environments: Activation of latent tgf‐β and sensitization of cellular responses to tgf‐β and egf

1989 • 69 citations

Transforming Growth Factor β1: Importance of Glycosylaytion and Acidic Proteases for Processing and Secretion

1989 • 64 citations

Transforming Growth Factor β Increases Cell Surface Binding and Assembly of Exogenous (Plasma) Fibronectin by Normal Human Fibroblasts

1988 • 60 citations

Stimulation of fibroblast proliferation by thrombospondin

1989 • 58 citations

Recombinant Type 1 Transforming Growth Factor β Precursor Produced in Chinese Hamster Ovary Cells Is Glycosylated and Phosphorylated

1988 • 53 citations

Characterization of the binding of transforming growth factor-beta 1, -beta 2, and -beta 3 to recombinant beta 1-latency-associated peptide.

1992 • 33 citations

One of two subunits of masking protein in latent TGF‐β is a part of pro‐TGF‐β

1989 • 25 citations

Activation of human platelet-derived latent transforming growth factor-β1 by human glioblastoma cells. Comparison with proteolytic and glycosidic enzymes

1991 • 20 citations