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Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

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NF-κB regulation in the immune system

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2003 • 3,164 citations

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1996 • 1,771 citations

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2001 • 1,333 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

2001 • 1,193 citations

The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1

2002 • 934 citations

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

1997 • 820 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

The p65 (RelA) Subunit of NF-κB Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression

2001 • 708 citations

Analysis Of Htlv-I Proviral Load In 202 Ham/Tsp Patients And 243 Asymptomatic Htlv-I Carriers: High Proviral Load Strongly Predisposes To Ham/Tsp

1998 • 678 citations

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

1999 • 665 citations

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

1994 • 657 citations

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

2000 • 637 citations

IκB kinases: key regulators of the NF-κB pathway

2004 • 618 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

2003 • 568 citations

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1998 • 531 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

2003 • 512 citations

Recruitment of the IKK Signalosome to the p55 TNF Receptor

2000 • 457 citations

Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

2001 • 457 citations

Tumor Necrosis Factor α-induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II

2000 • 445 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

1990 • 439 citations

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering

1987 • 438 citations

Transcriptional Activation by NF-κB Requires Multiple Coactivators

1999 • 433 citations

In vivo cellular tropism of human T-cell leukemia virus type 1

1990 • 425 citations

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2000 • 418 citations

HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy

1999 • 417 citations

Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm

1997 • 405 citations

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

1995 • 364 citations

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP

1996 • 344 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

Essential role of RelA Ser311 phosphorylation by PKC in NF- B transcriptional activation

2003 • 317 citations

A critical role for telomeres in suppressing and facilitating carcinogenesis

2000 • 314 citations

HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization

1993 • 312 citations

Calreticulin

1997 • 307 citations

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

1989 • 289 citations

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

1997 • 278 citations

A Transgenic Mouse Model for Human Neurofibromatosis

1987 • 278 citations

Abundant Tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes

2000 • 274 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins.

1988 • 273 citations

Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8+ T cells, and disease severity in HTLV-1–associated myelopathy (HAM/TSP)

2002 • 272 citations

HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation

1998 • 260 citations

The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1.

1993 • 258 citations

The immune control and cell-to-cell spread of human T-lymphotropic virus type 1

2003 • 257 citations

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat

1987 • 251 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes.

1992 • 237 citations

Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation

1999 • 232 citations

p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage

2003 • 231 citations

Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB

1996 • 228 citations

IKKγ Serves as a Docking Subunit of the IκB Kinase (IKK) and Mediates Interaction of IKK with the Human T-cell Leukemia Virus Tax Protein

1999 • 227 citations

Mutations of the p53 gene in adult T-cell leukemia

1992 • 223 citations

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

1990 • 222 citations

Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence

1988 • 218 citations

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

1999 • 216 citations

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

1990 • 210 citations

Ablation of Transplanted HTLV-I Tax-Transformed Tumors in Mice by Antisense Inhibition of NF-κB

1992 • 207 citations

Immortalization of CD4⁺and CD8⁺T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone

1999 • 204 citations

Selection Forces and Constraints on Retroviral Sequence Variation

2001 • 198 citations

Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.

1996 • 193 citations

Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

1998 • 188 citations

Alternative lengthening of telomeres, telomerase, and cancer

2003 • 186 citations

Increased replication of HTLV‐I in HTLV‐I–associated myelopathy

1989 • 179 citations

HTLV-1 Tax induces expression of various immediate early serum responsive genes.

1991 • 177 citations

Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site

1998 • 176 citations

Fratricide among CD8+ T Lymphocytes Naturally Infected with Human T Cell Lymphotropic Virus Type I

2000 • 176 citations

Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

1998 • 174 citations

HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication

2004 • 174 citations

Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing.

2002 • 172 citations

Life, Death, and Tax: Role of HTLV-I Oncoprotein in Genetic Instability and Cellular Transformation

2004 • 169 citations

Persistent clonal proliferation of human T-lymphotropic virus type I-infected cells in vivo.

1997 • 167 citations

Selective Ablation of Human T-Cell Lymphotropic Virus Type 1 p12I Reduces Viral Infectivity In Vivo

1998 • 162 citations

Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB).

1993 • 161 citations

Immunopathogenesis of Human T Cell Lymphotropic Virus Type I–Associated Neurologic Disease

2002 • 156 citations

Identification of a Novel Inhibitor of Nuclear Factor-κB, RelA-associated Inhibitor

1999 • 152 citations

The Tax Oncoprotein of Human T-cell Leukemia Virus Type 1 Associates with and Persistently Activates IκB Kinases Containing IKKα and IKKβ

1998 • 152 citations

Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21

1995 • 151 citations

Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

1999 • 147 citations

p53 functional impairment and high p21waf1/cip1 expression in human T- cell lymphotropic/leukemia virus type I-transformed T cells

1996 • 145 citations

Chromosome abnormalities in adult T-cell leukemia/lymphoma: a karyotype review committee report.

1992 • 144 citations

Variability in nucleotide excision repair and cancer risk: a review

2000 • 142 citations

Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for transcriptional activation.

1994 • 142 citations

Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways

1997 • 139 citations

PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner

1999 • 134 citations

Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T- cell leukemia/lymphoma

1995 • 134 citations

Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations

1992 • 132 citations

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

1997 • 131 citations

Repression of Bax Gene Expression by the HTLV-I Tax Protein: Implications for Suppression of Apoptosis in Virally Infected Cells

1997 • 131 citations

A trans-activator Tax of human T-cell leukemia virus type 1 binds to NF-kappa B p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kappa B site and CArG box.

1993 • 129 citations

Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells

1998 • 129 citations

Functional Role of pX Open Reading Frame II of Human T-Lymphotropic Virus Type 1 in Maintenance of Viral Loads In Vivo

2000 • 127 citations

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-κB

2001 • 126 citations

Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.

1996 • 125 citations

Fas Gene Mutation in the Progression of Adult T Cell Leukemia

1999 • 124 citations

Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway.

1991 • 124 citations

Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia.

1997 • 121 citations

Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.

1995 • 121 citations

Human T-Cell Leukemia Virus Type 1 Tax Requires Direct Access to DNA for Recruitment of CREB Binding Protein to the Viral Promoter

1998 • 120 citations

Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein

1999 • 120 citations

Regulation of Gene Expression by HTLV-I Tax Protein

1998 • 120 citations

Differential Transcriptional Activation by Human T-Cell Leukemia Virus Type 1 Tax Mutants Is Mediated by Distinct Interactions with CREB Binding Protein and p300

1998 • 119 citations

HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

2000 • 118 citations

Defective DNA Repair in Cells With Human T-Cell Leukemia/Bovine Leukemia Viruses: Role of tax Gene

1999 • 117 citations

Activation of the Heterodimeric IκB Kinase α (IKKα)-IKKβ Complex Is Directional: IKKα Regulates IKKβ under Both Basal and Stimulated Conditions

2000 • 114 citations

Characterization of Human Activating Transcription Factor 4, a Transcriptional Activator That Interacts with Multiple Domains of cAMP-responsive Element-binding Protein (CREB)-binding Protein (CBP)

1997 • 114 citations

Inhibition of Apoptosis in T Cells Expressing Human T Cell Leukemia Virus Type I Tax

1994 • 112 citations

Prevalent Loss of Mitotic Spindle Checkpoint in Adult T-cell Leukemia Confers Resistance to Microtubule Inhibitors

2002 • 110 citations

SINK Is a p65-interacting Negative Regulator of NF-κB-dependent Transcription

2003 • 107 citations

Human T-cell Lymphotropic Virus Type 1 Tax Induction of Biologically Active NF-κB Requires IκB Kinase-1-mediated Phosphorylation of RelA/p65

2004 • 107 citations

X-I and X-II Open Reading Frames of HTLV-I Are Not Required for Virus Replication or for Immortalization of Primary T-Cellsin Vitro

1997 • 106 citations

Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki

2001 • 105 citations

Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration

2003 • 103 citations

Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-κB activation

2001 • 101 citations

Multiple Control Levels of Cell Proliferation by Human T-Cell Leukemia Virus Type 1 Tax Protein

1999 • 100 citations

Evidence for the Chronic in Vivo Production of Human T Cell Leukemia Virus Type I Rof and Tof Proteins from Cytotoxic T Lymphocytes Directed against Viral Peptides

2000 • 99 citations

Characterization of a novel nuclear localization signal in the HTLV-I tax transactivator protein

1992 • 98 citations

Inhibition of Caspase Cascade by HTLV-I Tax Through Induction of NF-κB Nuclear Translocation

1999 • 98 citations

Aberrant expression of caspase cascade regulatory genes in adult T‐cell leukaemia: survivin is an important determinant for prognosis

2001 • 98 citations

Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB.

1994 • 97 citations

Human T-cell leukemia-lymphoma virus type I (HTLV-I) expression in fresh peripheral blood mononuclear cells from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy

1991 • 96 citations

Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways.

2001 • 95 citations

Human T Cell Lymphotropic Virus Type I Tax Activates IL-15Rα Gene Expression Through an NF-κB Site

2001 • 95 citations

Characterization of a Nuclear Export Signal within the Human T Cell Leukemia Virus Type I Transactivator Protein Tax

2003 • 95 citations

The contribution of NF-κB activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors

2001 • 94 citations

Human T-Cell Leukemia Virus Type 1 pX-I and pX-II Open Reading Frames Are Dispensable for the Immortalization of Primary Lymphocytes

1998 • 93 citations

Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells

1999 • 92 citations

The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins

1997 • 91 citations

Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription.

1994 • 90 citations

Human T-Lymphotropic Virus Type 1 Open Reading Frame I p12^IIs Required for Efficient Viral Infectivity in Primary Lymphocytes

2000 • 89 citations

Inactivation of hTERT transcription by Tax

2003 • 89 citations

Protein Profile of Tax-associated Complexes

2003 • 88 citations

HTLV-1 tax activation of the GM-CSF and G-CSF promoters requires the interaction of NF-kB with other transcription factor families.

1993 • 87 citations

A Human T-cell Leukemia Virus Tax Variant Incapable of Activating NF-κB Retains Its Immortalizing Potential for Primary T-lymphocytes

1998 • 86 citations

Telomere repeat binding factors: keeping the ends in check

2003 • 85 citations

Critical Role of Human T-Lymphotropic Virus Type 1 Accessory Proteins in Viral Replication and Pathogenesis

2002 • 85 citations

Human T-Lymphotropic Virus Type 1 p30 ^II Regulates Gene Transcription by Binding CREB Binding Protein/p300

2001 • 85 citations

Nuclear Role of IκB Kinase-γ/NF-κB Essential Modulator (IKKγ/NEMO) in NF-κB-dependent Gene Expression

2004 • 84 citations

Complex Formation between CREB and Tax Enhances the Binding Affinity of CREB for the Human T-Cell Leukemia Virus Type 1 21-Base-Pair Repeats

1996 • 83 citations

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes

1997 • 82 citations

Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4)

1997 • 81 citations

Human T-Lymphotropic Virus Type 1 p30 ^II Functions as a Transcription Factor and Differentially Modulates CREB-Responsive Promoters

2000 • 80 citations

Human T-Cell Lymphotropic Virus Type 1 Open Reading Frame II-Encoded p30 ^II Is Required for In Vivo Replication: Evidence of In Vivo Reversion

2004 • 79 citations

Inhibitors of Protein Kinase C (PKC) Prevent Activated Transcription

2004 • 79 citations

Trans-activator Tax of Human T-Cell Leukemia Virus Type 1 Enhances Mutation Frequency of the Cellular Genome

1999 • 78 citations

Role of IKKγ/NEMO in Assembly of the IκB Kinase Complex

2001 • 76 citations

Functional analysis of human T-cell leukemia virus type I rex-response element: direct RNA binding of Rex protein correlates with in vivo activity

1991 • 76 citations

Selective Ablation of Human T-Cell Lymphotropic Virus Type 1 p12I Reduces Viral Infectivity In Vivo

1998 • 75 citations

The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein

1995 • 74 citations

HTLV-I Tax self-association in optimal trans-activation function

1997 • 73 citations

Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks

2000 • 73 citations

Telomerase and tumorigenesis

2003 • 72 citations

Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element.

1996 • 69 citations

Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter

1997 • 68 citations

Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements.

1991 • 67 citations

A model of in vivo cell proliferation of adult T-cell leukemia

1993 • 66 citations

Segregation of NF-κB activation through NEMO/IKKγ by Tax and TNFα: implications for stimulus-specific interruption of oncogenic signaling

2003 • 66 citations

Role of the Fas/Fas ligand pathway in apoptotic cell death induced by the human T cell lymphotropic virus type I Tax transactivator.

1997 • 66 citations

Transcription profile of cells infected with human T-cell leukemia virus type I compared with activated lymphocytes.

2002 • 66 citations

ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death

1997 • 65 citations

Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax

2001 • 64 citations

Molecular Interactions Involved in the Transactivation of the Human T-Cell Leukemia Virus Type 1 Promoter Mediated by Tax and CREB-2 (ATF-4)

2000 • 63 citations

CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein

2001 • 63 citations

Specific Regions of Contact between Human T-cell Leukemia Virus Type I Tax Protein and DNA Identified by Photocross-linking

1998 • 62 citations

Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo

1995 • 62 citations

HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro

2003 • 60 citations

Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals

1993 • 60 citations

Mice Transgenic for HTLV-I LTR-tax Exhibit Tax Expression in Bone, Skeletal Alterations, and High Bone Turnover

1993 • 59 citations

Clonal Expansion Within CD4+ and CD8+ T Cell Subsets in Human T Lymphotropic Virus Type I-Infected Individuals

1998 • 58 citations

Variable Immortalizing Potential and Frequent Virus Latency in Blood-Derived T-Cell Clones Infected With Human T-Cell Leukemia Virus Type I

1997 • 58 citations

IκB Kinase α (IKKα) Regulation of IKKβ Kinase Activity

2000 • 57 citations

p53 gene mutation and loss of heterozygosity are associated with increased risk of disease progression in adult T cell leukemia.

1995 • 56 citations

Correlation of telomerase activity with development and progression of adult T-cell leukemia

1999 • 55 citations

HTLV-1 Tax Enhances NF-κB2 Expression and Binds to the Products p52 and p100, but Does Not Suppress the Inhibitory Function of p100

1995 • 55 citations

Tax protein of human T-cell leukemia virus type I is required for maintenance of the transformed phenotype.

1992 • 54 citations

Tumours derived from HTLV-Itax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression

1998 • 54 citations

Damaged DNA and miscounted chromosomes: Human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells

2002 • 54 citations

Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes

1996 • 53 citations

Sp1-p53 Heterocomplex Mediates Activation of HTLV-I Long Terminal Repeat by 12-O-Tetradecanoylphorbol-13-acetate That Is Antagonized by Protein Kinase C

2001 • 53 citations

Suppression of DNA Repair by HTLV Type 1 Tax Correlates with Taxtrans-Activation of Proliferating Cell Nuclear Antigen Gene Expression

2000 • 53 citations

HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents

2000 • 53 citations

Human T-lymphotropic Virus Type I Tax Protein Utilizes Distinct Pathways for p53 Inhibition That Are Cell Type-dependent

2001 • 52 citations

The HTLV-1 Rex Protein Induces Nuclear Accumulation of Unspliced Viral RNA by Avoiding Intron Excision and Degradation

1996 • 50 citations

Analysis of Domains in the IKKα and IKKβ Proteins That Regulate Their Kinase Activity

2000 • 48 citations

The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa B enhancer include the product of the c-rel proto-oncogene.

1993 • 45 citations

Suppression of DNA Repair by Human T Cell Leukemia Virus Type 1 Tax Is Rescued by a Functional p53 Signaling Pathway

2000 • 44 citations

Molecular Mechanism of Tumorigenesis in Mice Transgenic for the Human T Cell Leukemia VirusTaxGene

1998 • 42 citations

Is human T–cell lymphotropic virus type I really silent?

2000 • 42 citations

Human T cell lymphotropic virus type I genomic expression and impact on intracellular signaling pathways during neurodegenerative disease and leukemia

2000 • 41 citations

Expression of Survivin in HTLV-I-Infected T-Cell Lines and Primary ATL Cells

2001 • 41 citations

Identification of the Tax interaction region of serum response factor that mediates the aberrant induction of immediate early genes through CArG boxes by HTLV-I Tax.

1995 • 41 citations

Cell cycle dysregulation by HTLV-I: role of the TAX oncoprotein

2002 • 40 citations

trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein

1992 • 38 citations

In Vitroandin VivoFunctional Analysis of Human T Cell Lymphotropic Virus Type 1 pX Open Reading Frames I and II

2000 • 38 citations

The CDKN2 gene alterations in various types of adult T‐cell leukaemia

1996 • 37 citations

The Human T-Cell Lymphoma/Leukemia Viruses

2003 • 37 citations

Tax-Dependent Stimulation of G₁Phase-Specific Cyclin-Dependent Kinases and Increased Expression of Signal Transduction Genes Characterize HTLV Type 1-Transformed T Cells

2000 • 37 citations

Effect of human serum anti‐htlv antibodies on viral antigen induction in In vitro cultured peripheral lymphocytes from adult T‐CELL leukemia patients and healthy virus carriers

1985 • 37 citations

KIX-Mediated Assembly of the CBP−CREB−HTLV-1 Tax Coactivator−Activator Complex

2003 • 37 citations

Activation of Oncogenic Transcription Factor AP-1 in T Cells Infected with Human T Cell Leukemia Virus Type 1

2000 • 35 citations

Ternary Complex Factors and Cofactors Are Essential for Human T-Cell Leukemia Virus Type 1 Tax Transactivation of the Serum Response Element

2000 • 34 citations

Analysis of p53 Inactivation in a Human T-Cell Leukemia Virus Type 1 Tax Transgenic Mouse Model

2001 • 34 citations

Activation of HTLV-I Long Terminal Repeat by Stress-Inducing Agents and Protection of HTLV-I-Infected T-cells from Apoptosis by the Viral Tax Protein

2001 • 34 citations

p21^{Waf1/Cip1/Sdi1}Prevents Apoptosis as Well as Stimulates Growth in Cells Transformed or Immortalized by Human T-Cell Leukemia Virus Type 1-Encoded Tax

2003 • 33 citations

Activation of I-κB Kinase by the HTLV Type 1 Tax Protein: Mechanistic Insights into the Adaptor Function of IKKγ

2000 • 33 citations

A novel alternatively spliced viral mRNA transcribed in cells infected with human T cell leukemia virus type 1 is mainly responsible for expressing p21X protein

1991 • 32 citations

Engraftment and tumorigenesis of HTLV-1 transformed T cell lines in SCID/bg and NOD/SCID mice

2002 • 31 citations

Human T-cell Leukemia Virus Type I Tax Masks c-Myc Function through a cAMP-dependent Pathway

1996 • 30 citations

Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells.

2004 • 29 citations

Stimulation of IKK‐γ oligomerization by the human T‐cell leukemia virus oncoprotein Tax

2002 • 29 citations

Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex.

2004 • 28 citations

Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells.

2003 • 28 citations

HTLV-1 Tax Oncoprotein Binds to DNA Topoisomerase I and Inhibits Its Catalytic Activity

2000 • 28 citations

Efficient repair of bulky anti-BPDE DNA adducts from non-transcribed DNA strand requires functional p53 but not p21waf1/cip1 and pRb

2002 • 27 citations

Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-Cells

2003 • 24 citations

Transformation studies with a human T-cell leukemia virus type 1 molecular clone

2003 • 24 citations

Pleiotropic Effects of HTLV Type 1 Tax Protein on Cellular Metabolism: Mitotic Checkpoint Abrogation and NF-κB Activation

2000 • 24 citations

Human T Cell Leukemia Virus Type 1 Tax Protein Increases NF-κB Dimer Formation and Antagonizes the Inhibitory Activity of the IκBα Regulatory Protein

1996 • 23 citations

Role of protein kinase C and the Sp1-p53 complex in activation of p21WAF-1 expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells

2003 • 22 citations

Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction

2000 • 20 citations

Unusual CD4+CD8+ phenotype in a Greek patient diagnosed with adult T-cell leukemia positive for human T-cell leukemia virus type I (HTLV-I)

2000 • 19 citations

Expression and phosphorylation status of retinoblastoma protein in adult T-cell leukemia/lymphoma

2000 • 19 citations

Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells

1998 • 18 citations

Adult T-cell leukemia: future prophylaxis and immunotherapy

2004 • 18 citations

Augmentation of c-fos and c-jun expression in transgenic mice carrying the human T-cell leukemia virus type-Itax gene

1995 • 17 citations

Studies of the Immortalizing Activity of HTLV Type 1 Tax, Using an Infectious Molecular Clone and Transgenic Mice

2000 • 17 citations

The Long Terminal Repeats of Human Immunodeficiency Virus Type-1 and Human T-cell Leukemia Virus Type-I Are Activated by 12-O-Tetradecanoylphorbol- 13-acetate through Different Pathways

1997 • 16 citations

Short Communication: Telomerase Activity of Human Peripheral Blood Mononuclear Cells in the Course of HTLV Type 1 Infection in Vitro

2002 • 16 citations

Expression and functional properties of proteins encoded in the x-II ORF of HTLV-I

2001 • 15 citations

Implications of the evolution pattern of human T-cell leukemia retroviruses on their pathogenic virulence (Review)

2004 • 14 citations

A colony assay for in vitro transformation by human T cell leukemia viruses type I and type II

1987 • 14 citations

Multiple γc‐receptor expression in adult T‐cell leukemia

2002 • 13 citations

HTLV-I Transgenic Models: An Overview

1996 • 13 citations

The tumor suppressor protein p53 stimulates the formation of the human topoisomerase I double cleavage complex in vitro

2002 • 12 citations

A colony assay for in vitro transformation by human T cell leukemia viruses type I and type II

1987 • 11 citations

Activation of HTLV-I long terminal repeat by apoptosis inducing agents: Mechanism and implications for HTLV-I pathogenicity (Review)

2003 • 10 citations

Damaged DNA and Miscounted Chromosomes: Human T Cell Leukemia Virus Type I Tax Oncoprotein and Genetic Lesions in Transformed Cells

2002 • 8 citations

Tumours derived from HTLV‐I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression

1998 • 7 citations

Expression of theGfi-1 Gene in HTLV-I-Transformed T Cells

2001 • 7 citations

Benign monoclonal T cell proliferation in HTLV-I infection

1993 • 7 citations

Tax-independent stimulation of human T-cell leukemia virus type-I expression and differential effects on its infectivity by subtoxic and toxic doses of 3-methylcholanthrene.

1995 • 6 citations

Chromosome changes associated with growth potential of HTLV-I infected human lymphocytes.

1997 • 6 citations

Genetic instability as a basis for transformation of human lymphocytes infected with human retrovirus.

1996 • 5 citations

Multistep alterations of human lymphocytes infected with HTLV-I and then exposed to carcinogens.

1994 • 2 citations

Deleted Work

1955 • 0 citations