HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

1998 • 2,061 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

1998 • 535 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.

1990 • 401 citations

HUMAN T CELL LEUKEMIA VIRUS TYPE I (HTLV-I) AND HUMAN DISEASES

1997 • 395 citations

mdm-2 Inhibits the G₁ Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

1996 • 354 citations

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP

1996 • 344 citations

Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor

1996 • 315 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.

1992 • 230 citations

Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73

1998 • 194 citations

Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.

1996 • 193 citations

Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

1998 • 188 citations

Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein

1998 • 174 citations

Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

1998 • 174 citations

An Exposed KID-Like Domain in Human T-Cell Lymphotropic Virus Type 1 Tax Is Responsible for the Recruitment of Coactivators CBP/p300

1998 • 174 citations

p53 functional impairment and high p21waf1/cip1 expression in human T- cell lymphotropic/leukemia virus type I-transformed T cells

1996 • 145 citations

Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells

1998 • 134 citations

Inactivation of p53 but Not p73 by Adenovirus Type 5 E1B 55-Kilodalton and E4 34-Kilodalton Oncoproteins

1998 • 133 citations

Transactivation Ability of p53 Transcriptional Activation Domain Is Directly Related to the Binding Affinity to TATA-binding Protein

1995 • 124 citations

Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein

1999 • 120 citations

Binding of p53 to the KIX Domain of CREB Binding Protein

1999 • 108 citations

Distinct Regulation of p53 and p73 Activity by Adenovirus E1A, E1B, and E4orf6 Proteins

1999 • 95 citations

Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site

1999 • 94 citations

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes

1997 • 82 citations

Aberrant expression and function of p53 in T‐cells immortalized by HTLV‐I Tax1

1997 • 81 citations

Trans-activator Tax of Human T-Cell Leukemia Virus Type 1 Enhances Mutation Frequency of the Cellular Genome

1999 • 78 citations

Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains

1999 • 71 citations

Genetic Alteration of p53 in Some Patients with Adult T‐Cell Leukemia

1991 • 66 citations

Aberrant Expression of the p53 Tumor Suppressor Gene in Adult T‐Cell Leukemia and HTLV‐I‐infected Cells

1993 • 64 citations

Inhibition of p53-mediated transactivation by E6 of type 1, but not type 5, 8, or 47, human papillomavirus of cutaneous origin

1994 • 59 citations

Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73

1998 • 55 citations

Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control

1999 • 49 citations

Molecular Cloning of cDNA Encoding gp68 of Adult T-Cell Leukaemia-associated Antigen: Evidence for Expression of the pX IV Region of Human T-Cell Leukaemia Virus

1985 • 28 citations