Alternative lengthening of telomeres, telomerase, and cancer

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

Mammalian Telomeres End in a Large Duplex Loop

1999 • 2,372 citations

Oxidative stress shortens telomeres

2002 • 2,362 citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 • 2,281 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

A theory of marginotomy

1973 • 1,770 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Telomere states and cell fates

2000 • 1,359 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1997 • 1,244 citations

A telomerase component is defective in the human disease dyskeratosis congenita

1999 • 1,135 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening

1997 • 897 citations

Telomere maintenance by recombination in human cells

2000 • 844 citations

Senescence Induced by Altered Telomere State, Not Telomere Loss

2002 • 787 citations

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1999 • 695 citations

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.

1999 • 659 citations

Alternative lengthening of telomeres in mammalian cells

2002 • 646 citations

Telomerase in the human organism

2002 • 594 citations

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

1999 • 545 citations

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

2002 • 427 citations

A highly selective telomerase inhibitor limiting human cancer cell proliferation

2001 • 408 citations

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes

2001 • 374 citations

DNA Ligase IV-Dependent NHEJ of Deprotected Mammalian Telomeres in G1 and G2

2002 • 370 citations

DNA damage and repair in telomeres: relation to aging.

1995 • 326 citations

Evidence for a New Step in Telomere Maintenance

1996 • 304 citations

Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?

2000 • 302 citations

Telomerase and the maintenance of chromosome ends

1999 • 296 citations

Telomere lengthening and telomerase activation during human B cell differentiation

1997 • 263 citations

Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells

2001 • 239 citations

The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity

2000 • 223 citations

The role of senescence and immortalization in carcinogenesis

2000 • 211 citations

A novel mechanism for telomere size control in Saccharomyces cerevisiae.

1996 • 199 citations

HeT-A, a transposable element specifically involved in "healing" broken chromosome ends in Drosophila melanogaster.

1992 • 180 citations

Telomerase beyond telomeres

2002 • 174 citations

Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas

2001 • 174 citations

Telomere maintenance by telomerase and by recombination can coexist in human cells

2001 • 169 citations

Telomerase Activation in Mouse Mammary Tumors: Lack of Detectable Telomere Shortening and Evidence for Regulation of Telomerase RNA with Cell Proliferation

1996 • 157 citations

Impaired germinal center reaction in mice with short telomeres

2000 • 149 citations

Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells

2002 • 126 citations

Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase.

2001 • 117 citations

Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids

1999 • 107 citations

Chromosome End Elongation by Recombination in the Mosquito Anopheles gambiae

1997 • 104 citations

Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells

2001 • 96 citations

Telomerase activity in human renal cell carcinoma.

1996 • 92 citations

Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway

2001 • 86 citations

Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors

2002 • 72 citations

Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts

1998 • 60 citations

Decrease in Amplified Telomeric Sequences and Induction of Senescence Markers by Introduction of Human Chromosome 7 or Its Segments in SUSM-1

1997 • 59 citations

The Werner Syndrome: A Model for the Study of Human Aging

2000 • 52 citations

[The Werner syndrome].

1980 • 24 citations