p21^{Waf1/Cip1/Sdi1}Prevents Apoptosis as Well as Stimulates Growth in Cells Transformed or Immortalized by Human T-Cell Leukemia Virus Type 1-Encoded Tax

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

1997 • 725 citations

Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation

1999 • 587 citations

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

1995 • 561 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

p21WAF1/Cip1: more than a break to the cell cycle?

2000 • 482 citations

Genetic determinants of p53-induced apoptosis and growth arrest.

1996 • 472 citations

Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

2001 • 457 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

1990 • 439 citations

AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival

2002 • 435 citations

Effects of p21^{Waf1/Cip1/Sdi1}on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases

2000 • 426 citations

HUMAN T CELL LEUKEMIA VIRUS TYPE I (HTLV-I) AND HUMAN DISEASES

1997 • 395 citations

Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

2001 • 354 citations

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

1997 • 305 citations

Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

1999 • 238 citations

Immortalization of CD4⁺and CD8⁺T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone

1999 • 204 citations

Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.

1996 • 193 citations

Akt Is a Downstream Target of NF-κB

2002 • 187 citations

p53 functional impairment and high p21waf1/cip1 expression in human T- cell lymphotropic/leukemia virus type I-transformed T cells

1996 • 145 citations

Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein

2002 • 140 citations

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I

2001 • 131 citations

The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein

1994 • 129 citations

Expression of cell-cycle regulatory genes in HTLV-I infected T-cell lines: possible involvement of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1.

1996 • 128 citations

A Novel Transcriptional Repression Domain Mediates p21^WAF1/CIP1 Induction of p300 Transactivation

2000 • 126 citations

Down-regulation of the INK4 Family of Cyclin-Dependent Kinase Inhibitors by Tax Protein of HTLV-1 through Two Distinct Mechanisms

1999 • 119 citations

HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

2000 • 118 citations

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes

1997 • 82 citations

Overexpression of p21 ^waf1 in Human T-Cell Lymphotropic Virus Type 1-Infected Cells and Its Association with Cyclin A/cdk2

2000 • 80 citations

The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression

2002 • 75 citations

The p21^WAF1/CIP1 Promoter Is Methylated in Rat-1 Cells: Stable Restoration of p53-Dependent p21^WAF1/CIP1 Expression after Transfection of a Genomic Clone Containing the p21^WAF1/CIP1 Gene

2000 • 69 citations

ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death

1997 • 65 citations

Resistance to Fas-mediated Apoptosis of Peripheral T Cells in Human T Lymphocyte Virus Type I (HTLV-I) Transgenic Mice with Autoimmune Arthropathy

1997 • 63 citations

Human T Cell Leukemia Virus-I (HTLV-I) Tax-Mediated Apoptosis in Activated T Cells Requires an Enhanced Intracellular Prooxidant State

1998 • 61 citations

Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis in human malignant glioma cells

2001 • 58 citations

Distinct p300-Responsive Mechanisms Promote Caspase-Dependent Apoptosis by Human T-Cell Lymphotropic Virus Type 1 Tax Protein

2000 • 55 citations

HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents

2000 • 53 citations

Differences in sensitivity to induction of apoptosis among rat fibroblast cells transformed by HTLV-I tax gene or cellular nuclear oncogenes.

1995 • 32 citations

A cooperative interaction of human T-cell leukemia virus type 1 Tax with the p21 cyclin-dependent kinase inhibitor activates the human immunodeficiency virus type 1 enhancer

1996 • 21 citations