Telomere repeat binding factors: keeping the ends in check

Mammalian Telomeres End in a Large Duplex Loop

1999 • 2,372 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1999 • 1,326 citations

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

2001 • 1,161 citations

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

2000 • 1,077 citations

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 • 1,076 citations

Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans

2001 • 1,010 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2

1997 • 913 citations

Senescence Induced by Altered Telomere State, Not Telomere Loss

2002 • 787 citations

A Human Telomeric Protein

1995 • 689 citations

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

2000 • 600 citations

Identification of Human Rap1

2000 • 559 citations

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

2001 • 525 citations

TIN2, a new regulator of telomere length in human cells

1999 • 523 citations

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

2001 • 521 citations

Telomeric localization of TRF2, a novel human telobox protein

1997 • 495 citations

Different telomere damage signaling pathways in human and mouse cells

2002 • 475 citations

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1999 • 397 citations

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase

1997 • 376 citations

Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

1999 • 373 citations

DNA Ligase IV-Dependent NHEJ of Deprotected Mammalian Telomeres in G1 and G2

2002 • 370 citations

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

2000 • 346 citations

Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein

1999 • 338 citations

Ku acts in a unique way at the mammalian telomere to prevent end joining

2000 • 338 citations

Accelerated telomere shortening in ataxia telangiectasia

1996 • 334 citations

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

2000 • 329 citations

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G‐strand overhang

2000 • 323 citations

Ku is associated with the telomere in mammals

1999 • 321 citations

Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres

2002 • 302 citations

The Pin2/TRF1-Interacting Protein PinX1 Is a Potent Telomerase Inhibitor

2001 • 300 citations

New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

2002 • 297 citations

Strand-Specific Postreplicative Processing of Mammalian Telomeres

2001 • 259 citations

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

1999 • 255 citations

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc^−/− mice with short telomeres

2001 • 254 citations

The Telobox, a Myb-Related Telomeric DNA Binding Motif Found in Proteins from Yeast, Plants and Human

1996 • 224 citations

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

2002 • 219 citations

TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression

2001 • 215 citations

The Absence of the DNA-Dependent Protein Kinase Catalytic Subunit in Mice Results in Anaphase Bridges and in Increased Telomeric Fusions with Normal Telomere Length and G-Strand Overhang

2001 • 201 citations

Nuclear structure in normal and Bloom syndrome cells

2000 • 189 citations

Interaction of human Ku70 with TRF2

2000 • 181 citations

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments

1999 • 178 citations

Ku Binds Telomeric DNA in Vitro

1999 • 134 citations

Extra-chromosomal telomeric DNA in cells from Atm-/- mice and patients with ataxia-telangiectasia

2001 • 124 citations

Elongated Telomeres inscidMice

1999 • 91 citations

Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase–deficient mice and primary cells despite increased chromosomal instability

2001 • 88 citations