Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

1981 • 2,281 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Diagnostic criteria and classification of clinical subtypes of adult T‐cell leukaemia‐lymphoma

1991 • 1,527 citations

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

1981 • 1,429 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

Modelling the risk of adult T‐cell leukemia/lymphoma in persons infected with human T‐lymphotropic virus type I

1989 • 391 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus.

1983 • 354 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Restricted expression of human T-Cell leukemia-lymphoma virus (HTLV) in Transformed human umbilical cord blood lymphocytes

1983 • 332 citations

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines

1996 • 318 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 312 citations

Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy

1995 • 308 citations

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells.

1985 • 237 citations

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.

1996 • 232 citations

The Molecular Basis of X‐Linked Severe Combined Immunodeficiency: The Role of the Interleukin‐2 Receptor γ Chain as a Common γ Chain, γc

1994 • 180 citations

The First Human Retrovirus

1986 • 168 citations

Signaling via IL-2 and IL-4 in JAK3-Deficient Severe Combined Immunodeficiency Lymphocytes: JAK3-Dependent and Independent Pathways

1996 • 129 citations

Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.

1995 • 121 citations

Infection and transformation of fresh human umbilical cord blood cells by multiple sources of human T‐cell leukemia‐lymphoma virus (HTLV)

1983 • 111 citations

Autocrine growth of interleukin 2-producing leukemic cells in a patient with adult T cell leukemia

1986 • 98 citations

Reflections on STAT3, STAT5, and STAT6 as fat STATs.

1996 • 96 citations

Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus

1995 • 81 citations

Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts

1996 • 75 citations

Adult T-cell leukemia/lymphoma on a background of clonally expanding human T-cell leukemia virus type-1-positive cells

1996 • 62 citations

Leukemic cells from some adult T-cell leukemia patients proliferate in response to interleukin-4

1988 • 56 citations

The Solar Cycle in Precambrian Time

1986 • 54 citations

Expression of Cytokine mRNA in Leukemic Cells from Adult T Cell Leukemia Patients

1989 • 48 citations

STATs and cytokine specificity

1996 • 45 citations

Clonal selection of human T-cell leukemia virus-infected cells in vivo and in vitro.

1984 • 23 citations

Immunodeficiencies caused by genetic defects in protein kinases

1996 • 20 citations

Relation of autonomous and interleukin-2-responsive growth of leukemic cells to survival in adult T-cell leukemia

1996 • 16 citations

Signal Transduction by Interleukin‐12 and Interleukin‐2

1996 • 13 citations