Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

1985 • 2,840 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein

1987 • 1,074 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

A simple phase-extraction assay for chloramphenicol acyltransferase activity

1988 • 1,006 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Proliferating cell nuclear antigen is required for DNA excision repair

1992 • 809 citations

Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells

1984 • 781 citations

Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

1994 • 559 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

An auxiliary protein for DNA polymerase-delta from fetal calf thymus.

1986 • 500 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Regulation of Proliferating Cell Nuclear Antigen during the Cell Cycle

1989 • 447 citations

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

1994 • 415 citations

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.

1990 • 401 citations

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

1988 • 361 citations

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

1989 • 359 citations

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

1992 • 318 citations

HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization

1993 • 312 citations

Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture

1992 • 311 citations

Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.

1987 • 309 citations

A Transgenic Mouse Model for Human Neurofibromatosis

1987 • 278 citations

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat

1987 • 251 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes.

1992 • 237 citations

Regulation of the proliferating cell nuclear antigen cyclin and thymidine kinase mRNA levels by growth factors.

1988 • 235 citations

Cyclin: A nuclear protein whose level correlates directly with the proliferative state of normal as well as transformed cells

1984 • 231 citations

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

1990 • 222 citations

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

1990 • 210 citations

Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

1986 • 175 citations

HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

1988 • 171 citations

T-Cell Activation Signals and Human T-Cell Leukemia Virus Type I-Encoded p40^x Protein Activate the Mouse Granulocyte-Macrophage Colony-Stimulating Factor Gene Through a Common DNA Element

1988 • 171 citations

Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen

1989 • 150 citations

Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells.

1991 • 143 citations

Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway.

1991 • 124 citations

Effect of human T-cell leukemia virus type I tax protein on activation of the human vimentin gene

1990 • 124 citations

Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors.

1993 • 121 citations

Human T-lymphotropic virus I-infected T cells constitutively express lymphotoxin in vitro

1989 • 99 citations

Transformation-sensitive and Growth-related Changes of Protein Synthesis in REF52 Cells

1989 • 96 citations

Specific disruption of intermediate filaments and the nuclear lamina by the 19-kDa product of the adenovirus E1B oncogene.

1989 • 84 citations

A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeat.

1990 • 81 citations

The adenovirus E1A transforming protein activates the proliferating cell nuclear antigen promoter via an activating transcription factor site

1991 • 74 citations

Direct interaction of CREB protein with 21 bp Tax-response elements of HTLV-ILTR.

1992 • 69 citations

Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements.

1991 • 67 citations

Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1.

1990 • 58 citations

Indirect immunofluorescence studies of proliferating cell nuclear antigen in nucleoli of human tumor and normal tissues.

1983 • 51 citations

Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes.

1994 • 44 citations

The adenovirus E1B 19-kilodalton protein stimulates gene expression by increasing DNA levels.

1989 • 44 citations

Identification of multiplecis-elements andtrans-acting factors involved in the induced expresson of human IL-2 gene

1989 • 39 citations

A complex promoter element mediates transactivation of the human proliferating cell nuclear antigen promoter by the 243-residue adenovirus E1A oncoprotein.

1993 • 32 citations

Activation of Skeletal α-Actin Gene Transcription: The Cooperative Formation of Serum Response Factor-Binding Complexes over Positive cis-Acting Promoter Serum Response Elements Displaces a Negative-Acting Nuclear Factor Enriched in Replicating Myoblasts and Nonmyogenic Cells

1991 • 28 citations

Chromosome and gene rearrangements in immortalized human lymphocytes infected with human T-lymphotropic virus type I.

1990 • 25 citations

The Adenovirus E1B 19-Kilodalton Protein Stimulates Gene Expression by Increasing DNA Levels

1989 • 24 citations

Twenty-One Base Pair Repeat Elements Influence the Ability of a Gal4-Tax Fusion Protein to Transactivate the HTLV-I Long Terminal Repeat

1993 • 22 citations

Differential precipitation and zinc chelate chromatography purification of biologically active HTLV-I Tax1 expressed in E. coli

1991 • 20 citations

Promoter Activity of the Proliferating-Cell Nuclear Antigen Gene Is Associated with Inducible CRE-Binding Proteins in Interleukin 2-Stimulated T Lymphocytes

1994 • 12 citations

A Complex Promoter Element Mediates Transactivation of the Human Proliferating Cell Nuclear Antigen Promoter by the 243-Residue Adenovirus E1A Oncoprotein

1993 • 10 citations