Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

1981 • 1,429 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

The p53 Network

1998 • 731 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Isolation and Transmission of Human Retrovirus (Human T-Cell Leukemia Virus)

1983 • 568 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.

1990 • 401 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection

1995 • 373 citations

Functional inactivation but not structural mutation of p53 causes liver cancer

1995 • 364 citations

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

1997 • 364 citations

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

1989 • 359 citations

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP

1996 • 344 citations

Restricted expression of human T-Cell leukemia-lymphoma virus (HTLV) in Transformed human umbilical cord blood lymphocytes

1983 • 332 citations

Frequent Mutations in the p53 Tumor Suppressor Gene in Human Leukemia T-Cell Lines

1990 • 296 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells

1997 • 244 citations

Mutations of the p53 gene in adult T-cell leukemia

1992 • 223 citations

Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.

1990 • 195 citations

Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.

1996 • 193 citations

Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia

1995 • 175 citations

Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein

1998 • 174 citations

The First Human Retrovirus

1986 • 168 citations

Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias

1994 • 164 citations

Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers.

1992 • 150 citations

p53 functional impairment and high p21waf1/cip1 expression in human T- cell lymphotropic/leukemia virus type I-transformed T cells

1996 • 145 citations

Localization of the E1 B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies

1985 • 145 citations

Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations

1992 • 132 citations

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

1997 • 131 citations

The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein

1994 • 129 citations

Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells.

1985 • 128 citations

Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms.

1995 • 125 citations

Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.

1995 • 121 citations

Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia.

1997 • 121 citations

Functional and biochemical interaction of the HTLV-I Tax1 transactivator with TBP.

1993 • 119 citations

Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I.

1993 • 107 citations

p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis

1997 • 89 citations

Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells

1997 • 83 citations

Aberrant expression and function of p53 in T‐cells immortalized by HTLV‐I Tax1

1997 • 81 citations

Immediate effects of reversible HTLV-ITax function: T-cell activation and apoptosis

1995 • 81 citations

Adenovirus Serotype Determines Association and Localization of the Large E1B Tumor Antigen with Cellular Tumor Antigen p53 in Transformed Cells

1985 • 68 citations

Aberrant Expression of the p53 Tumor Suppressor Gene in Adult T‐Cell Leukemia and HTLV‐I‐infected Cells

1993 • 64 citations

HTLV-1 Oncoprotein Tax and Cellular transcription Factors

1995 • 61 citations

p53 gene mutation and loss of heterozygosity are associated with increased risk of disease progression in adult T cell leukemia.

1995 • 56 citations

Cell surface phenotype and human T lymphotropic virus type 1 antigen expression in 12 T cell lines derived from peripheral blood and cerebrospinal fluid of West Indian, Guyanese and African patients with tropical spastic paraparesis

1990 • 50 citations

Expression of an ATP binding mutant of PKC-delta inhibits Sis-induced transformation of NIH3T3 cells.

1996 • 48 citations

Perturbation of the p53 response by human papillomavirus type 16 E7

1997 • 44 citations

p53 and tumour viruses: Catching the guardian off-guard

1997 • 33 citations

Functional inactivation of wild-type p53 protein correlates with loss of IL-2 dependence in HTLV-I transformed human T lymphocytes.

1995 • 31 citations

Molecular analysis of a deletion mutant provirus of type I human T-cell lymphotropic virus: evidence for a doubly spliced x-lor mRNA.

1986 • 26 citations

Regulation of Viral and Cellular Gene Expression by E1A Proteins Encoded by the Oncogenic Adenovirus Type 12

1995 • 26 citations

Short Communication: Deletion of the p16^INK4AGene inex VivoAcute Adult T Cell Lymphoma/Leukemia Cells and Methylation of the p16^INK4APromoter in HTLV Type I-Infected T Cell Lines

2000 • 22 citations

Power of Stupefying Spiders possessed by Wasps.—Mimicry in Birds

1878 • 2 citations