Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

DNA EXCISION REPAIR

1996 • 1,127 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

1998 • 857 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

1998 • 752 citations

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

1995 • 736 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

The base excision repair pathway

1995 • 536 citations

Two Pathways for Base Excision Repair in Mammalian Cells

1996 • 520 citations

Chapter 5 Generation of High-Titer Pseudotyped Retroviral Vectors with Very Broad Host Range

1994 • 452 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Expression of Wild-type p53 Is Required for Efficient Global Genomic Nucleotide Excision Repair in UV-irradiated Human Fibroblasts

1997 • 365 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

1995 • 351 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

1996 • 346 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.

1996 • 318 citations

Allosteric activation of latent p53 tetramers

1994 • 302 citations

The genetic regulation of apoptosis

1995 • 283 citations

p53 and apoptosis

1998 • 282 citations

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1994 • 276 citations

p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

1994 • 264 citations

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

1996 • 248 citations

Interaction of p53 with the Human Rad51 Protein

1997 • 212 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.

1995 • 188 citations

Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeast

1994 • 163 citations

Relationship of p53 to the control of apoptotic cell death.

1994 • 163 citations

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

1995 • 160 citations

The dual role model for p53 in maintaining genomic integrity

1999 • 150 citations

DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae.

1993 • 141 citations

Mutant p53 protein expression interferes with p53-independent apoptotic pathways

1998 • 138 citations

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

1998 • 138 citations

A temperature-sensitive mutant of human p53.

1994 • 128 citations

The dnaN gene codes for the beta subunit of DNA polymerase III holoenzyme of escherichia coli.

1981 • 116 citations

Alternatively Spliced Forms in the Carboxy-Terminal Domain of the p53 Protein Regulate Its Ability to Promote Annealing of Complementary Single Strands of Nucleic Acids

1995 • 107 citations

p53-dependent DNA repair and apoptosis respond differently to high- and low-dose ultraviolet radiation.

1998 • 100 citations

Evidence that DNA polymerases alpha and beta participate differentially in DNA repair synthesis induced by different agents.

1982 • 91 citations

Repair of UV-damaged DNA by mammalian cells and Saccharomyces cerevisiae

1994 • 75 citations

The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo

1997 • 61 citations

Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP.

1994 • 60 citations

Faculty DNA polymerase δ/ɛ-mediated excision repair in response to γ radiation or ultraviolet light in p53-deficient fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome

1996 • 53 citations

Different Regulation of the p53 Core Domain Activities 3′-to-5′ Exonuclease and Sequence-Specific DNA Binding

1999 • 52 citations

Complex Formation between p53 and Replication Protein A Inhibits the Sequence-Specific DNA Binding of p53 and Is Regulated by Single-Stranded DNA

1997 • 52 citations

Temperature sensitivity for conformation is an intrinsic property of wild-type p53

1995 • 51 citations

Cooperation between p53-dependent and p53-independent apoptotic pathways in myeloid cells.

1996 • 48 citations

Protein kinase C isoform levels in normal and sodium dodecyl sulphate-irritated mouse skin

1998 • 41 citations

Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopoietic cells.

1996 • 28 citations

Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen

1992 • 26 citations

The DNA binding activity of wild type p53 is modulated by blocking its various antigenic epitopes.

1995 • 18 citations

The C-terminal domain of p53 catalyzes DNA-renaturation and strand exchange toward annealing between intact ssDNAs and toward eliminating damaged ssDNA from duplex formation through preferential recognition of damaged DNA by a duocarmycin

1998 • 6 citations

A temperature-sensitive defect of enterovirus 70 is located at the uridylylation of the genome-linked protein VPg in vitro

1989 • 4 citations