Inhibitors of Protein Kinase C (PKC) Prevent Activated Transcription

NF-κB regulation in the immune system

2002 • 3,804 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

CBP/p300 in cell growth, transformation, and development

2000 • 1,712 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1

2002 • 934 citations

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

1997 • 820 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain

1999 • 812 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

2001 • 774 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

2000 • 720 citations

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

1998 • 678 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

2000 • 637 citations

The p38 Mitogen-activated Protein Kinase Is Required for NF-κB-dependent Gene Expression

1999 • 444 citations

Transcriptional Activation by NF-κB Requires Multiple Coactivators

1999 • 433 citations

IKKβ Plays an Essential Role in the Phosphorylation of RelA/p65 on Serine 536 Induced by Lipopolysaccharide

2003 • 383 citations

Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

2001 • 375 citations

Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529

1998 • 375 citations

Activation of IκB Kinase β by Protein Kinase C Isoforms

1999 • 366 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.

1987 • 360 citations

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters

2002 • 355 citations

Phosphorylation of CBP Mediates Transcriptional Activation by Neural Activity and CaM Kinase IV

2002 • 329 citations

Essential role of RelA Ser311 phosphorylation by PKC in NF- B transcriptional activation

2003 • 317 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

Novel Roles of Specific Isoforms of Protein Kinase C in Activation of the c-fos Serum Response Element

1999 • 255 citations

IκB-independent control of NF-κB activity by modulatory phosphorylations

2001 • 241 citations

Activation of Transcription Factor NF-κB and p38 Mitogen-activated Protein Kinase Is Mediated by Distinct and Separate Stress Effector Pathways

1997 • 239 citations

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1994 • 231 citations

Three NF-χB sites in the IχB-α promoter are required for induction of gene expression by TNFα

1994 • 219 citations

Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit

1997 • 208 citations

Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA

1998 • 203 citations

IκBα Degradation and Nuclear Factor-κB DNA Binding Are Insufficient for Interleukin-1β and Tumor Necrosis Factor-α-induced κB-dependent Transcription

1998 • 194 citations

Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial Cells

1999 • 192 citations

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

1999 • 165 citations

Transactivation Domain 2 (TA2) of p65 NF-κB

1995 • 161 citations

Inhibition of the NF‐κB transcriptional activity by protein kinase A

2002 • 155 citations

Expression of PKA inhibitor (PKI) gene abolishes cAMPmediated protection to endothelial barrier dysfunction

1999 • 141 citations

Atypical PKC ζ is activated by ceramide, resulting in coactivation of NF-κb/JNK kinase and cell survival

1999 • 135 citations

Inhibition of TNF- α -induced NF- κ B Activation and IL-8 Release in A549 Cells with the Proteasome Inhibitor MG-132

1998 • 122 citations

NF-κB Activation in Tumor Necrosis Factor α-stimulated Neutrophils Is Mediated by Protein Kinase Cδ

2001 • 117 citations

The IκB Kinase (IKK) Complex Is Tripartite and Contains IKKγ but Not IKAP as a Regular Component

2000 • 116 citations

Phosphorylation of p300 at Serine 89 by Protein Kinase C

2000 • 112 citations

Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta.

1994 • 111 citations

Functional Testing of Human Dopamine D₁And D₅Receptors Expressed in Stable camp-Responsive Luciferase Reporter Cell Lines

1993 • 108 citations

Promoter of the human NF-kappa B p50/p105 gene. Regulation by NF-kappa B subunits and by c-REL.

1993 • 104 citations

Effect of dexamethasone on interleukin‐1β‐(IL‐1β)‐induced nuclear factor‐κB (NF‐κB) and κB‐dependent transcription in epithelial cells

1998 • 100 citations

IL‐1β‐dependent activation of NF‐κB mediates PGE₂ release via the expression of cyclooxygenase‐2 and microsomal prostaglandin E synthase

2003 • 99 citations

Superinduction of NF-κB by Actinomycin D and Cycloheximide in Epithelial Cells

1996 • 83 citations

CREB Binding Protein Recruitment to the Transcription Complex Requires Growth Factor–Dependent Phosphorylation of Its GF Box

2001 • 78 citations

Up-Regulation of Protein Kinase C-ϵ Promotes the Expression of Cytokine-inducible Nitric Oxide Synthase in RAW 264.7 Cells

1996 • 74 citations

Tumor Necrosis Factor-α-dependent Activation of a RelA Homodimer in Astrocytes

1995 • 55 citations

Ceramide Induction of COX-2 and PGE2 in Pulmonary A549 Cells Does Not Involve Activation of NF-κB

2000 • 34 citations

Functional Characterization of the Human Neurokinin Receptors NK1, NK2, and NK3 Based on a Cellular Assay System

1995 • 24 citations

GM-CSF Expression in Pulmonary Epithelial Cells Is Regulated Negatively by Posttranscriptional Mechanisms

2001 • 20 citations