Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

1981 • 2,281 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

1983 • 1,555 citations

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

1984 • 886 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering

1987 • 438 citations

Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I

1987 • 423 citations

Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies

1981 • 417 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

Expression of functional acetylcholine receptor from cloned cDNAs

1984 • 366 citations

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

1988 • 361 citations

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

1989 • 359 citations

A Transcriptional Activator Protein Encoded by the x- lor Region of the Human T-Cell Leukemia Virus

1985 • 346 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing

1988 • 308 citations

Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in Japan

1982 • 304 citations

Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells

1984 • 293 citations

A Transgenic Mouse Model for Human Neurofibromatosis

1987 • 278 citations

Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins.

1988 • 273 citations

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

1987 • 245 citations

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

1986 • 229 citations

Identification of the Putative Transforming Protein of the Human T-Cell Leukemia Viruses HTLV-I and HTLV-II

1984 • 215 citations

A survey of human leukaemias for sequences of a human retrovirus

1983 • 195 citations

Augmented T cell growth factor receptor expression in HTLV-1-infected human leukemic T cells.

1984 • 192 citations

Antigens Encoded by the 3′-Terminal Region of Human T-Cell Leukemia Virus: Evidence for a Functional Gene

1984 • 191 citations

HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

1988 • 171 citations

Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth.

1988 • 169 citations

p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I.

1985 • 166 citations

Subcellular Localization of the Product of the Long Open Reading Frame of Human T-Cell Leukemia Virus Type I

1985 • 128 citations

Activation of T cell-derived lymphokine genes in T cells and fibroblasts: effects of human T cell leukemia virus type I p40^xprotein and bovine papilloma virus encoded E2 protein

1988 • 115 citations

Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expression.

1988 • 107 citations

Studies of the Putative Transforming Protein of the Type I Human T-Cell Leukemia Virus

1985 • 97 citations

Expression of a Provirus of Human T Cell leukaemia Virus Type I by DNA Transfection

1987 • 52 citations

Heterogeneity in response to interleukin 2 and interleukin 2-producing ability of adult T cell leukemic cells.

1987 • 46 citations

Defective human T-cell leukemia virus in adult T-cell leukemia patients.

1984 • 44 citations

Transient induction of IL-2 receptor in cultured T cell lines by HTLV-1 LTR-linked tax-1 gene.

1989 • 22 citations

Differential effects on expression of IL‐2 receptors (p55 and p70) by the HTLV‐I pX DNA

1988 • 22 citations

Functional mapping of the activity of the R region in the human T-cell leukemia virus type I long terminal repeat to increase gene expression

1989 • 17 citations