Activation of I-κB Kinase by the HTLV Type 1 Tax Protein: Mechanistic Insights into the Adaptor Function of IKKγ

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Predicting Coiled Coils from Protein Sequences

1991 • 3,977 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

How NF-κB is activated: the role of the IκB kinase (IKK) complex

1999 • 1,133 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate

1998 • 450 citations

The Rel/NF-κB signal transduction pathway: introduction

1999 • 436 citations

MEKK1 activates both IκB kinase α and IκB kinase β

1998 • 382 citations

IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex

1999 • 333 citations

High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.

1991 • 269 citations

HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation

1998 • 260 citations

IKKγ Serves as a Docking Subunit of the IκB Kinase (IKK) and Mediates Interaction of IKK with the Human T-cell Leukemia Virus Tax Protein

1999 • 227 citations

Human T-Cell Leukemia Virus Type 1 Tax Induction of NF-κB Involves Activation of the IκB Kinase α (IKKα) and IKKβ Cellular Kinases

1998 • 221 citations

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

1999 • 216 citations

Immortalization of CD4⁺and CD8⁺T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone

1999 • 204 citations

Human T-Cell Leukemia Virus Type I Tax Activation of NF-ΝB/Rel Involves Phosphorylation and Degradation of IΙBκ and RelA (p65)-Mediated Induction of the italic toc-rel Gene

1994 • 186 citations

IKKγ Mediates the Interaction of Cellular IκB Kinases with the Tax Transforming Protein of Human T Cell Leukemia Virus Type 1

1999 • 181 citations

Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis

1999 • 180 citations

Inactivation of IκBβ by the Tax Protein of Human T-Cell Leukemia Virus Type 1: a Potential Mechanism for Constitutive Induction of NF-κB

1996 • 166 citations

NF-κB-inducing Kinase and IκB Kinase Participate in Human T-cell Leukemia Virus I Tax-mediated NF-κB Activation

1998 • 155 citations

Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia.

1991 • 153 citations

The Tax Oncoprotein of Human T-cell Leukemia Virus Type 1 Associates with and Persistently Activates IκB Kinases Containing IKKα and IKKβ

1998 • 152 citations

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene.

1994 • 142 citations

Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation

1991 • 116 citations

Somatic mutagenesis studies of NF-κB signaling in human T cells: evidence for an essential role of IKKγ in NF-κB activation by T-cell costimulatory signals and HTLV-I Tax protein

2000 • 111 citations

Characterization of a Mutant Cell Line That Does Not Activate NF-κB in Response to Multiple Stimuli

1997 • 82 citations

Regulation of human T cell leukemia virus expression ¹

1990 • 78 citations

Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta

1996 • 74 citations

Recombinant IκB Kinases α and β Are Direct Kinases of IκBα

1998 • 70 citations

IκB Kinases Serve as a Target of CD28 Signaling

1998 • 69 citations

Cellular transformation by human T-cell leukemia virus type I

1996 • 36 citations

Cellular transformation by human T-cell leukemia virus type I

1996 • 5 citations