Fas Gene Mutation in the Progression of Adult T Cell Leukemia

Apoptosis by Death Factor

1997 • 5,038 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

1981 • 2,281 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 2,119 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 1,750 citations

Diagnostic criteria and classification of clinical subtypes of adult T‐cell leukaemia‐lymphoma

1991 • 1,527 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

1984 • 886 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

Fas and FasL in the homeostatic regulation of immune responses

1995 • 579 citations

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

1993 • 506 citations

FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity

1996 • 486 citations

Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing.

1995 • 398 citations

A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.

1992 • 272 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 228 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Mutations of the p53 gene in adult T-cell leukemia

1992 • 223 citations

Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia

1989 • 204 citations

An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro.

1996 • 199 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 183 citations

Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.

1997 • 177 citations

Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia

1995 • 175 citations

Inhibition of PDGF β Receptor Signal Transduction by Coexpression of a Truncated Receptor

1991 • 173 citations

Missense Mutations in the Fas Gene Resulting in Autoimmune Lymphoproliferative Syndrome: A Molecular and Immunological Analysis

1997 • 168 citations

Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma

1983 • 166 citations

Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia

1990 • 146 citations

APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

1993 • 131 citations

Chemotherapeutic results and prognostic factors of patients with advanced non-Hodgkin's lymphoma treated with VEPA or VEPA-M.

1988 • 131 citations

Mutation of CD95 (Fas/Apo-1) Gene in Adult T-Cell Leukemia Cells

1998 • 130 citations

Inhibition of Tyrosine Kinase Activity of the Epidermal Growth Factor (EGF) Receptor by a Truncated Receptor Form That Binds to EGF: Role for Interreceptor Interaction in Kinase Regulation

1989 • 125 citations

CD95 (APO-1/Fas) Mutations in Childhood T-Lineage Acute Lymphoblastic Leukemia

1998 • 121 citations

Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia.

1997 • 121 citations

A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice.

1996 • 104 citations

Phenotypic diversity and prognosis of adult T-cell leukemia

1992 • 103 citations

Features of the Cytokines Secreted by Adult T Cell Leukemia (ATL) Cells

1996 • 93 citations

Loss of Fas/Apo-1 receptor accelerates lymphomagenesis in E mu L-MYC transgenic mice but not in animals infected with MoMuLV.

1995 • 76 citations

Characteristics of chemotherapy-induced clinical remission in long survivors with aggressive adult T-cell leukemia/lymphoma

1993 • 70 citations

Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors.

1994 • 68 citations

Quantitative characterization and potential function of membrane Fas/APO‐1 (CD95) receptors on leukaemic cells from chronic B and T lymphoid leukaemias

1997 • 37 citations

Soluble and membrane isoforms of Fas/CD95 in fresh adult T-cell leukemia (ATL) cells and ATL-cell lines

1997 • 30 citations

Established IL‐2‐dependent double‐negative (CD4^‐ CD8^‐) TCRαβ/CD3⁺ ATL cells: induction of CD4 expression

1994 • 27 citations

Serum Levels of Soluble Fas/APO-1 Receptor in Human Retroviral Infection and Associated Diseases.

1997 • 23 citations

Search for Rearrangements and/or Allelic Loss of the fas/APO-1 Gene in 101 Human Lymphoma

1995 • 20 citations

Expression of functional Fas antigen on adult T-cell leukemia

1994 • 19 citations

Cell Transformation by Fibroblast Growth Factors Can Be Suppressed by Truncated Fibroblast Growth Factor Receptors

1994 • 18 citations