Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB).

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells

1984 • 781 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.

1989 • 396 citations

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

1992 • 318 citations

The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1.

1993 • 258 citations

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat

1987 • 251 citations

Transcription factors: a new family gathers at the cAMP response site

1990 • 244 citations

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

1986 • 229 citations

Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation

1985 • 215 citations

Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription.

1986 • 212 citations

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

1990 • 210 citations

A transcriptional enhancer sequence of HTLV-I is responsible for trans-activation mediated by p40 chi HTLV-I.

1986 • 190 citations

Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer.

1991 • 188 citations

Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

1986 • 175 citations

The x Gene Is Essential for HTLV Replication

1985 • 161 citations

Two distinct forms of active transcription factor CREB (cAMP response element binding protein).

1990 • 132 citations

Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I

1991 • 123 citations

Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors.

1993 • 121 citations

Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expression.

1988 • 107 citations

Identification of Multiple Nuclear Factors That Interact with Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein and Activating Transcription Factor-2 by Protein-Protein Interactions

1991 • 103 citations

Direct interaction of CREB protein with 21 bp Tax-response elements of HTLV-ILTR.

1992 • 69 citations

Promoter-dependent Transcription by RNA Polymerase II Using Immobilized Enzyme Complexes

1989 • 69 citations

Interaction of cellular proteins with the human T-cell leukemia virus type I transcriptional control region. Purification of cellular proteins that bind the 21-base pair repeat elements.

1990 • 67 citations

Abundant synthesis of functional human T-cell leukemia virus type I p40x protein in eucaryotic cells by using a baculovirus expression vector

1987 • 66 citations

Human T-cell leukemia virus types I and II exhibit different DNase I protection patterns

1988 • 57 citations

Human T-cell leukemia/lymphoma viruses. Life cycle, pathogenicity, epidemiology, and diagnosis.

1991 • 56 citations

In vitro activation of transcription by the human T-cell leukemia virus type I Tax protein.

1992 • 45 citations

Protein kinase A-dependent binding of a nuclear factor to the 21-base-pair repeat of the human T-cell leukemia virus type I long terminal repeat

1990 • 34 citations

Role of protein kinase A in tax transactivation of the human T-cell leukemia virus type I long terminal repeat

1990 • 29 citations

Multistep regulation of enhancer activity of the 21-base-pair element of human T-cell leukemia virus type I

1992 • 16 citations