Molecular mechanisms of necroptosis: an ordered cellular explosion

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

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Signaling to NF-κB

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Mitochondrial Membrane Permeabilization in Cell Death

2007 • 3,375 citations

Circulating mitochondrial DAMPs cause inflammatory responses to injury

2010 • 3,267 citations

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

2008 • 3,166 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

2005 • 2,694 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

2009 • 2,172 citations

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

2009 • 2,016 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Identification of RIP1 kinase as a specific cellular target of necrostatins

2008 • 1,837 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

2009 • 1,767 citations

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

2005 • 1,570 citations

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

2009 • 1,449 citations

Extracellular histones are major mediators of death in sepsis

2009 • 1,398 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

2005 • 1,330 citations

Lysosomal membrane permeabilization in cell death

2008 • 1,297 citations

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

2008 • 1,258 citations

Regulation and Function of IKK and IKK-Related Kinases

2006 • 1,238 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

Mitochondrial Oxidative Stress: Implications for Cell Death

2006 • 1,212 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

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The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

2004 • 1,045 citations

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

2008 • 1,034 citations

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

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Programmed cell death

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Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

2006 • 956 citations

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

2008 • 949 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

2003 • 946 citations

CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

2003 • 932 citations

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

2009 • 914 citations

Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

2003 • 906 citations

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

2007 • 895 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

1998 • 887 citations

Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2

1997 • 842 citations

Phospholipase A2 structure/function, mechanism, and signaling

2008 • 839 citations

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

2005 • 793 citations

Necroptosis as an alternative form of programmed cell death

2010 • 732 citations

Nuclear factor-κB inhibitors as sensitizers to anticancer drugs

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The morphology of various types of cell death in prenatal tissues

1973 • 716 citations

Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update.

2002 • 671 citations

Apoptosis and necrosis: Detection, discrimination and phagocytosis

2008 • 649 citations

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

2009 • 648 citations

Alkylating DNA damage stimulates a regulated form of necrotic cell death

2004 • 618 citations

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

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Inhibition of NF-κB Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

2010 • 574 citations

Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

1998 • 553 citations

Virus Inhibition of RIP3-Dependent Necrosis

2010 • 542 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

Death receptor signal transducers: nodes of coordination in immune signaling networks

2009 • 540 citations

Cleavage of the Plasma Membrane Na+/Ca2+ Exchanger in Excitotoxicity

2005 • 532 citations

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

2007 • 530 citations

Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

2004 • 526 citations

Decoding Cell Death Signals in Inflammation and Immunity

2010 • 519 citations

TNF-Induced Activation of the Nox1 NADPH Oxidase and Its Role in the Induction of Necrotic Cell Death

2007 • 504 citations

Mitochondrial generation of free radicals and hypoxic signaling

2009 • 484 citations

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

2010 • 479 citations

RIP Kinases at the Crossroads of Cell Death and Survival

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Activation and Caspase-mediated Inhibition of PARP: A Molecular Switch between Fibroblast Necrosis and Apoptosis in Death Receptor Signaling

2002 • 470 citations

Diversity in the Mechanisms of Neuronal Cell Death

2003 • 468 citations

Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling

2006 • 463 citations

A Role for Tumor Necrosis Factor Receptor-2 and Receptor-interacting Protein in Programmed Necrosis and Antiviral Responses

2003 • 447 citations

Glutamine: A Trojan horse in ammonia neurotoxicity

2006 • 433 citations

Mitochondrial H+ leak and ROS generation: An odd couple

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Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain

2007 • 417 citations

Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells

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Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation

2004 • 407 citations

Mitochondrial membrane permeabilization in neuronal injury

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2008 • 392 citations

Programmed cell death—II. Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths

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Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD+ Depletion and Mitochondrial Permeability Transition

2004 • 366 citations

Sphingosine-induced apoptosis is dependent on lysosomal proteases

2001 • 339 citations

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

2000 • 336 citations

Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3

2002 • 336 citations

Molecular mechanisms of late apoptotic/necrotic cell clearance

2009 • 328 citations

Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation

2000 • 328 citations

Molecular Mechanisms and Pathophysiology of Necrotic Cell Death

2008 • 327 citations

The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes

2004 • 327 citations

Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia

2005 • 326 citations

Interdigital cell death can occur through a necrotic and caspase-independent pathway

1999 • 316 citations

Sequential Activation of Poly(ADP-Ribose) Polymerase 1, Calpains, and Bax Is Essential in Apoptosis-Inducing Factor-Mediated Programmed Necrosis

2007 • 312 citations

Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase

2002 • 308 citations

Critical Role of Calpain I in Mitochondrial Release of Apoptosis-Inducing Factor in Ischemic Neuronal Injury

2007 • 298 citations

Microbial Pathogen-Induced Necrotic Cell Death Mediated by the Inflammasome Components CIAS1/Cryopyrin/NLRP3 and ASC

2007 • 289 citations

Developmental apoptosis in C. elegans: a complex CEDnario

2006 • 283 citations

Lysosomes in iron metabolism, ageing and apoptosis

2008 • 274 citations

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

2008 • 268 citations

Phagocytosis in atherosclerosis: Molecular mechanisms and implications for plaque progression and stability

2006 • 265 citations

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

2008 • 263 citations

Sphingosine-induced apoptosis is dependent on lysosomal proteases

2001 • 258 citations

No death without life: vital functions of apoptotic effectors

2008 • 246 citations

Necroptosis, a novel form of caspase‐independent cell death, contributes to neuronal damage in a retinal ischemia‐reperfusion injury model

2009 • 244 citations

Impaired regulation of NF-κB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

2006 • 243 citations

Poly(ADP-ribose) Polymerase-1 Signaling to Mitochondria in Necrotic Cell Death Requires RIP1/TRAF2-mediated JNK1 Activation

2006 • 238 citations

Pharmacological manipulation of cell death: clinical applications in sight?

2005 • 236 citations

RIP3, a Novel Apoptosis-inducing Kinase

1999 • 222 citations

NALP Inflammasomes: a central role in innate immunity

2007 • 213 citations

Caspase Inhibitors Promote Alternative Cell Death Pathways

2006 • 210 citations

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

2009 • 209 citations

Phagocytosis of Necrotic Cells by Macrophages Is Phosphatidylserine Dependent and Does Not Induce Inflammatory Cytokine Production

2003 • 205 citations

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA‐074: a novel strategy for neuroprotection based on ‘calpain–cathepsin hypothesis’

1998 • 204 citations

NF-κB Suppression by the Deubiquitinating Enzyme Cezanne

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SLE—a disease of clearance deficiency?

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Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis

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Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase

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TNFα and reactive oxygen species in necrotic cell death

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Autophagy, ageing and apoptosis: The role of oxidative stress and lysosomal iron

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Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells

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Caspase Activation Inhibits Proteasome Function during Apoptosis

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Susceptibility of Lysosomes to Rupture Is a Determinant for Plasma Membrane Disruption in Tumor Necrosis Factor Alpha-Induced Cell Death

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Role of Murine Cytomegalovirus US22 Gene Family Members in Replication in Macrophages

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RIPK1 is not essential for TNFR1-induced activation of NF-κB

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Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress

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The role of lysosomal rupture in neuronal death

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Intralysosomal iron chelation protects against oxidative stress‐induced cellular damage

2006 • 164 citations

The Cardioprotective Effect of Necrostatin Requires the Cyclophilin-D Component of the Mitochondrial Permeability Transition Pore

2007 • 164 citations

AIF-Mediated Programmed Necrosis: A Highly Orchestrated Way to Die

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Disruption of HSP90 Function Reverts Tumor Necrosis Factor-induced Necrosis to Apoptosis

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Metals in our minds: therapeutic implications for neurodegenerative disorders

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Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation

1999 • 159 citations

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA

2002 • 148 citations

Glutamine homeostasis and mitochondrial dynamics

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The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose

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Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein

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Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells

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Sphingolipid signaling and redox regulation

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Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates

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Physiological cell death of chondrocytes in vivo is not confined to apoptosis

2000 • 123 citations

Ceramide mediates caspase‐independent programmed cell death

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Immune Response Against Dying Tumor Cells

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The Intimate Relation Between Nitric Oxide and Superoxide in Apoptosis and Cell Survival

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Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis

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Ubiquitin-specific Peptidase 21 Inhibits Tumor Necrosis Factor α-induced Nuclear Factor κB Activation via Binding to and Deubiquitinating Receptor-interacting Protein 1

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A deficiency in the in vivo clearance of apoptotic cells is a feature of the NOD mouse

2006 • 109 citations

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

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Tumor necrosis factor-α-induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool

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Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE

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Nuclear Heat Shock Protein 72 as a Negative Regulator of Oxidative Stress (Hydrogen Peroxide)-Induced HMGB1 Cytoplasmic Translocation and Release

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Phosphatidylserine exposure during early primary necrosis (oncosis) in JB6 cells as evidenced by immunogold labeling technique

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The Oxidative Metabolism of Glutamine

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NF-κB Protects Macrophages from Lipopolysaccharide-induced Cell Death

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Causal Role of Apoptosis-Inducing Factor for Neuronal Cell Death Following Traumatic Brain Injury

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The fate of epithelial cells in the human large intestine

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Mitochondria protection from hypoxia/reoxygenation injury with mitochondria heat shock protein 70 overexpression

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Regulation of Tumor Necrosis Factor-Induced, Mitochondria- and Reactive Oxygen Species-Dependent Cell Death by the Electron Flux through the Electron Transport Chain Complex I

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Tumour‐necrosis‐factor‐mediated cytotoxicity is correlated with phospholipase‐A₂ activity, but not with arachidonic acid release per se

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Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase–dependent manner

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The Mode of Death of Pig Kidney Cells Infected with Cowpox Virus Is Governed by the Expression of thecrmAGene

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Induction of Necrosis in Human Neutrophils byShigella flexneriRequires Type III Secretion, IpaB and IpaC Invasins, and Actin Polymerization

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Protein synthesis persists during necrotic cell death

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Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury

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Involvement of heat shock protein-70 in the mechanism of hydrogen peroxide-induced DNA damage: The role of lysosomes and iron

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Mechanisms of internalization of apoptotic and necrotic L929 cells by a macrophage cell line studied by electron microscopy

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Distinct Roles of Basal Steady-State and Induced H-Ferritin in Tumor Necrosis Factor-Induced Death in L929 Cells

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Reactions of^·NO,^·NO₂and peroxynitrite in membranes: Physiological implications

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Virulent Shigella flexneri Causes Damage to Mitochondria and Triggers Necrosis in Infected Human Monocyte-Derived Macrophages

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Physiological cell death of chondrocytes in vivo is not confined to apoptosis

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Structure–activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors

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Enhanced Cytoprotective Effects of the Inhibitor of Apoptosis Protein Cellular IAP1 through Stabilization with TRAF2

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Ceramide Induces Non-Apoptotic Cell Death in Human Glioma Cells

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Reactive oxygen species are involved in FasL-induced caspase-independent cell death and inflammatory responses

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Necrotic cell death and ‘necrostatins’: now we can control cellular explosion

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